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332篇 您的检索式：作者名="CRANE L"

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	题名	作者	年代	出处	被引量
1	Mechanosignaling activation of TGFβmaintains intervertebral disc homeostasis显示文摘Intervertebral disc(IVD) degeneration is the leading cause of disability with no disease-modifying treatment.IVD degeneration is associated with instable mechanical loading in the spine, but little is known about how mechanical stress regulates nucleus notochordal(NC) cells to maintain IVD homeostasis. Here we report that mechanical stress can result in excessive integrin α_vβ_6-mediated activation of transforming growth factor beta(TGFβ), decreased NC cell vacuoles, and increased matrix proteoglycan production, and results in degenerative disc disease(DDD). Knockout of TGFβ type II receptor(TβRII) or integrin α_v in the NC cells inhibited functional activity of postnatal NC cells and also resulted in DDD under mechanical loading.Administration of RGD peptide, TGFβ, and α_vβ_6-neutralizing antibodies attenuated IVD degeneration. Thus,integrin-mediated activation of TGFβ plays a critical role in mechanical signaling transduction to regulate IVD cell function and homeostasis. Manipulation of this signaling pathway may be a potential therapeutic target to modify DDD.	Qin Bian Lei Ma Amit Jain Janet L Crane Khaled Kebaish Mei Wan Zhengdong Zhang X Edward Guo Paul D Sponseller Cheryle A Seguin Lee H Riley Yongjun Wang Xu Cao	2017	Bone Research2017，5，1：	9
2	Analysis of curing kinetics in polymer composites显示文摘	Crane L W Dynes P J Kaelble D H	1973	Journal of Polymer Science1973，11，8：	1
3	Live cell analysis of aquaporin 4 ml/m23 interactions and regulated orthogonal array assembly in gilal cells显示文摘	Crane J M Bennett J L Verkman A S	2009	J Biol Chem2009，284，35：	1
4	Analysis of curing kinetics in polymer composites 显示文摘	Crane L W Dynes P J Kaelble D H	1973	Polymer Science :Polymer Letter Edition1973，11，：	1
5	Analysis of curing kinetics in polymer compos-ites显示文摘	Crane L W	1972	Polymer Science1972，，12：	1
6	Care of undocumented individuals with ESRD:a national survey of US nephrologists显示文摘	Hurley L Kempe A Crane LA	2009	Am J Kidney Dis2009，53，6：	1
7	Analysis of curing kinetics in polymer composites 显示文摘	L W Crane	1973	Journal of Polymer Science1973，，11：	1
8	Biochemical functions of coenzyme Q10显示文摘	CRANE F L	2001	J AmColl Nutr2001，20，6：	1
9	Design to maximize per- formance of a thermoelectric power generator with a dynamic thermal power source 显示文摘	CRANE D T BELL L E	2009	J of Energy Resour Tech2009，131，012401：	1
10	Flow past a stretching plate 显示文摘	CRANE L J	1970	Z Angew Math Physk1970，21，：	1
11	Plasmalemma redox functions in plants 显示文摘	Crane F L Moller I M	1988	Physiol Plant1988，73，：	1
12	Neonatal outcomes with placenta previa显示文摘	Crane JMG Van Den Hof MC Dodds L	1999	Obstet Gynecol1999，93，6：	1
13	Inhibition of murine osteogenic sarcomas by treatment with type Ⅰ or type Ⅱ interferon显示文摘	Crane J L Jr Glasgow L A Kern E R	1978	J Natl Cancer Inst1978，61，3：	1
14	Corporate Social Responsibility in Small- and Medium-size Enterprises : Investigating Em- ployee Engagement in Fair Trade Companies 显示文摘	Davies L A Crane A	2010	Busi- ness Ethics : A European Review2010，19，2：	1
15	Right-side dominance for song control in the zebra finch显示文摘	Willams H Crane L A Hale T K	1992	Neurobiol1992，23，8：	1
16	Intraopera- tive near-infrared fluorescence imaging for sentinel lymph node detection in vulvar cancer: first clinical results 显示文摘	CRANE L M THEMELIS G ARTS H J	2011	Gy- necologic Oncology2011，120，2：	1
17	Formation of polypeptide-dye multilayer by electrostatic self-assembly technique 显示文摘	Cooper T M Campbell A L Crane R L	1995	Langmuir1995，11，：	1
18	Analysis of Curing Kinetics in Polymer Composites显示文摘	Crane L W	1973	Journal of Polymer Science: Polymer Letter Edition1973，，11：	1
19	Structure of CheA,signal-transducing histidine kinase显示文摘	Bilwes A M Alex L A Crane B R Simon M I		0，，：	1
20	Analysis of curing kinetics in polymer composites 显示文摘	Crane L W Dynes P J Kaelble D H	1973	Journal of Polymer Science:Polymer letters Edition1973，11，8：	1

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