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| 1 | Erlotinib inhibits progression to dysplasia in a colitis-associated colon cancer model显示文摘AIM:To investigate the role of epidermal growth factor receptor(EGFR) in colitis-associated dysplasia using the EGFR tyrosine kinase inhibitor erlotinib.METHODS:Sprague-Dawley rats received trinitrobenzene sulfonic acid(TNBS;30 mg in 50% ethanol,ic),followed 6 wk later by reactivation with TNBS(5 mg/kg,iv) for 3 d.To induce colitis-associated dysplasia,rats then received TNBS(iv) twice a week for 10 wk.One group received erlotinib(10 mg/kg,ip) for 1 wk before the start of the reactivation of the colitis and 2 wk after(21 d);the rest received the vehicle.After rats were euthanized,the colons were removed and analyzed for damage and expression of the EGFR downstream effectors Erk1/2 and c-Myc.RESULTS:Ninety percent of the vehicle-treated animals had dysplasia in any region of the colon.Erlotinib-treated animals had a significant decrease in the incidence of dysplasia compared to vehicle-treated animals in all regions of the colon(50.00% ± 11.47% vs 90.00% ± 10.00% in proximal,P < 0.05;15.00% ± 8.19% vs 50.00% ± 16.67% in mid,P < 0.05;and 20.00% ± 9.17% vs 70.00% ± 15.28% in distal,P < 0.01).Erlotinib-treated animals also had reduced cell proliferation,reduced active Erk1/2,and reduced c-Myc in colon epithelium compared with the vehicle-treated animals.In vitro,erlotinib treatment was shown to markedly decrease c-Myc and pErk1/2 levels in rat epithelial cells.Proliferation of rat epithelial cells was stimulated by epidermal growth factor and inhibited by erlotinib(P < 0.05).CONCLUSION:Erlotinib can decrease the development of colitis-associated dysplasia,suggesting a potential therapeutic use for erlotinib in patients with long-standing colitis. | Beatriz Pagán Angel A Isidro Myrella L Cruz Domenico Coppola Caroline B Appleyard | 2011 | World Journal of Gastroenterology2011，17，44： | 1 |
| 2 | Efficacy and safety of levetiracetam in infants and young children with refractory epilepsy显示文摘 | Grosso S Cordelli D Franzoni E Coppola G Capovilla G Zamponie N | 2007 | Seizure2007，16，4： | 1 |
| 3 | Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tu- morigenesis显示文摘 | Takahashi Y Coppola D Matsushita N | 2007 | Nat Cell Bid2007，9，10： | 1 |
| 4 | Modeling of biomass devolatilization in a fluidized bed reator显示文摘 | FELICE R D COPPOLA G RAPAGNA S JAND N | 1999 | Can J Chem Eng1999，77，2： | 1 |
| 5 | Efficacy and safety of levetiracetam in infants and young children with refractory epilepsy 显示文摘 | Grosso S Cordelli DM Franzoni E Coppola G Capovilla G Zamponi N | 2007 | Seizure2007，16，4： | 1 |
| 6 | Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis 显示文摘 | Takahashi Y Coppola D Matsushita N | 2007 | Nat Cell Biol2007，9，10： | 1 |
| 7 | Liver microRNA hsa-miR- 125a-5p in HBV Chronic Infection: Correlation with HBV Replication and Disease Progression显示文摘 | Coppola N Potenza N Pisaturo M | 2013 | Plos One2013，8，65： | 1 |
| 8 | The inhibition of the highly expressed mill-221 and mill-222 impairs the growth of prostate carcinoma xenografts in mice显示文摘 | Mercatelli N Coppola V Bonci D | 2008 | PLoS One2008，3，12： | 1 |
| 9 | Virologic and clinical expressions of reciprocal inhibitory effect of hepatitis B, C, and delta viruses in patients with chronic hepatitis 显示文摘 | Sagnelli E Coppola N Scolastico C | 2000 | Hepatology2000，32，5： | 1 |
| 10 | Bif-1 interacts with Beclin 1 through UVRAG and regulates autophagy and tumorigenesis显示文摘 | Takahashi Y Coppola D Matsushita N | | 0，，： | 1 |
| 11 | Building trust in vir- tual teams 显示文摘 | Coppola N W Hiltz S R Rotten N G | 2004 | Transactions on Professional Communica- tion2004，47，2： | 1 |
| 12 | Rapid detection of neonatal sepsis using polymerase chain reaction显示文摘 | Laforgia N Coppola B Carbone R | 1997 | Acta Paediatr1997，86，10： | 1 |
| 13 | Efficiency offederal hospitals in the United States 显示文摘 | Harrison J P Coppola M N Wakefield M | 2004 | Journal of Medi-cal Systems2004，28，41： | 1 |
| 14 | A High quality draft consensus sequence of the genome of a heterozygous grapevine variety显示文摘 | VELASCO R ZHARKIKH A TROGGIO M CARTWRIGHT DA CESTARO A PRUSS D PINDO M FITZGERALD LM VEZZULLI S REID J MALACARNE G ILIEV D COPPOLA G WARDELL B MICHELETTI D MACALMA T FACCI M MITCHELL JT PERAZZOLLI M ELDREDGE G GATTO P OYZERSKI R MORETTO M GUTIN N STEFANINI M CHEN Y SEGALA C DAVENPORT C DEMATYTE L MRAZ A BAT- TILANA J STORMO K COSTA F TAO Q SI-AMMOUR A HARKINS T LACKEY A PERBOST C TAILLON B STELLA A SOLOVYEV V FAWCETY JA STERCK L VANDEPOELE K GRANDO SM TOPPO S MOSER C LANCHBURY J BOGDEN R SKOLNICK M SGARAMELLA V BHATNAGAR SK FONTANA P GUTIN A VAN DE PEER Y SALAMINI F VIOLA R | 2007 | PLoS One2007，2，： | 1 |
| 15 | Minimally invasive hallux valgus correction: a technical note and a feasibility study 显示文摘 | Maffulli N Oliva F Coppola C | 2005 | J Surg Orthop Adv2005，14，： | 1 |
| 16 | The Prevalence of Peripher- al and Central Hearing Impairment and Its Relation to Cognition in Older Adults显示文摘 | Quaranta N Coppola F Casulli M | 2015 | Audiology and Neumtology2015，19，1： | 1 |
| 17 | HBV superinfection in hepatitis C virus chronic carriers,viral interaction,and clinical course显示文摘 | Sagnelli E Coppola N Messina V | 2002 | Hepatology2002，36，5： | 1 |
| 18 | Microrheological modeling of flow-induced crystallization显示文摘 | Coppola S Grizzuti N Maffettone P L | 2001 | Macromolecules2001，34，14： | 1 |
| 19 | Influence of chronic coinfection with hepatitis B and C virus on liver histology显示文摘 | Sagnelli E Pasquale G Coppola N | 2004 | Infection2004，32，3： | 1 |
| 20 | HBV superinfection in hepatitis C virus chronic carriers, viral interaction, and clinical course显示文摘 | Sagnelli E Coppola N Messina V | 2002 | Hepatology2002，36，： | 1 |
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