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| 1 | Risk factors and natural history of breast cancer in younger Chinese women显示文摘AIM: To investigate the age differences in the risk factors, clinicopathological characteristics and patterns of treatment of female breast cancer patients. METHODS: Seven thousand one hundred and fiftytwo women with primary breast cancer from the Hong Kong Breast Cancer Registry were recruited after receiving patients' consent, they were asked to complete standardized questionnaires which captured their sociodemographic characteristics and risk factors associated with breast cancer development. Among them, clinicopathological data and patterns of treatment were further collected from medical records of 5523 patients with invasive breast cancers. Patients were divided into two groups according to the age at diagnosis: younger(< 40 years old) vs older patients(≥ 40 years old) for subsequent analyses.RESULTS: Analysis on the sociodemographic characteristics and exposure to risk factors were performed on 7152 women with primary breast cancer and the results revealed that younger patients were more likely to have unhealthy lifestyles; these include a lack of exercise(85.4% vs 73.2%, P < 0.001), having high stress in life(46.1% vs 35.5%, P < 0.001), having dairy/meat-rich diets(20.2% vs 12.9%, P < 0.001),having alcohol drinking habit(7.7% vs 5.2%, P = 0.002). Younger patients were also more likely to have hormone-related risk factors including nulliparity(43.3% vs 17.8%, P < 0.001) and an early age at menarche(20.7% vs 13.2%, P < 0.001). Analyses on clinicopathological characteristics and patterns of treatment were performed on 5523 women diagnosed with invasive breast cancer. The invasive tumours in younger patients showed more aggressive pathological features such as having a higher percentage of grade 3 histology(45.7% vs 36.5%, P < 0.001), having a higher proportion of tumours with lymphovascular invasion(39.6% vs 33.2%, P = 0.003), and having multifocal disease(15.7% vs 10.3%, P < 0.001); they received different patterns of treatment than their older counterparts.CONCLUSION: Younger patients in Hong Kong are more likely to encounter risk factors associated with breast cancer development and have more aggressive tumours than their older counterparts. | Winnie Yeo Hang-Mei Lee Amy Chan Emily YY Chan Miranda CM Chan Keeng-Wai Chan Sharon WW Chan Foon-Yiu Cheung Polly SY Cheung Peter HK Choi Josette SY Chor William WL Foo Wing-Hong Kwan Stephen CK Law Lawrence PK Li Janice WH Tsang Yuk Tung Lorna LS Wong Ting-Ting Wong Chun-Chung Yau Tsz-Kok Yau Benny CY Zee | 2014 | World Journal of Clinical Oncology2014，5，5： | 4 |
| 2 | Association of telomere length with authentic pluripotency of ES/iPS cells显示文摘Telomerase 和 telomeres 为干细胞的不定的复制是重要的。最近,体的房间的 telomeres 被发现是 reprogrammed 在导致的 pluripotent 干细胞(iPSCs ) 伸长。然而,在在胚胎的干细胞(转换字符) 或 iPSCs 的 vivo 的发展 pluripotency 的 telomeres 的角色直接没被探讨。我们证明有长 telomeres 的转换字符展出真发展 pluripotency,由完全的转换字符小狗以及 germline 能干的怪物的产生证实了在啮齿类动物可得到的最紧的测试。有短 telomeres 的转换字符显示出减少的 teratoma 形成和怪物生产,并且没能产生完全的转换字符小狗。Telomere 长度高度被相关(r > 0.8 ) 与转换字符的发展 pluripotency。短 telomeres 减少 proliferative 率或转换字符的能力,改变与 telomere epigenetics 有关的基因的表示,为 embryogenesis 重要的下面调整基因并且破坏细菌房间区别。而且,有更长的 telomeres 的 iPSCs 与短 telomeres 比那些与更高的效率产生怪物。我们功能的 telomeres 为 ESCs/iPSCs 的发展 pluripotency 是必要的并且建议那 telomere 长度可以提供一个珍贵标记评估干细胞 pluripotency 的数据表演,特别地当紧测试不是可行的时。 | Junjiu Huang Fang Wang Maja Okuka Na Liu Guangzhen Ji Xiaoying Ye Bingfeng Zuo Minshu Li Ping Liang William W Ge John CM Tsibris David L Keefe Lin Liu | 2011 | Cell Research2011，21，5： | 3 |
| 3 | Renal Morphology and function immediately after extracoporeal shock wave lithotripsy 显示文摘 | Kaude JV Williams CM Milner MR et aI | 1985 | AJR1985，145，2： | 1 |
| 4 | Investigation of uremic analytes in hemodialysate and their structural elucidation from accurate mass maps generated by amulti-dimensional liquid chromatography/masss pectrometry approach显示文摘 | GODFREY AR WILLIAMS CM DUDLEY E | 2009 | Rapid Commun Mass Spectrom2009，23，19： | 1 |
| 5 | Development of the role of director of advanced practice nursing显示文摘 | Rhodes CA FusileroJ Williams CM | 2010 | Nurs Eeon2010，28，1： | 1 |
| 6 | The effect of pleural pressure on the hypoxic pulmonary vaaocondtrictor response in closed cheat dogs显示文摘 | Hen L Williame JJ Alexander CM | 1988 | Aneath Analg1988，67，： | 1 |
| 7 | Antibrain antibodies in children with autism and their unaffected siblings 显示文摘 | Singer HS Morris CM Williams PN | 2006 | Journal of Neuroimmunology2006，178，： | 1 |
| 8 | Polymyalgia rheu- matica and giant cell arteritis 显示文摘 | Unwin B Williams CM Gilliland W | 2006 | Am Fam Physician2006，74，9： | 1 |
| 9 | The structure gnd function of central nervous system myelin显示文摘 | Williams KA Deber CM | 1993 | C rit Rev Clin Lab Sci1993，30，1： | 1 |
| 10 | Trusses in the management of hernia today显示文摘 | Cheek CM Williams MH Farndon JR | | 0，，： | 1 |
| 11 | Lowering homocysteine with B vi- tamins has no effect on blood pressure in older adults 显示文摘 | McMahon JA Skeaff CM Williams SM | 2007 | J Nutr2007，137，5： | 1 |
| 12 | Trealnierit of nevus of Ota by the Q-switched alexandrite laser 显示文摘 | Alsler TS Williams CM | 1995 | Dermatol Surg1995，，2： | 1 |
| 13 | Compaision of patient ABO/RH/Ktyping by a column agglutination system and convertionl tube methods显示文摘 | William son KP et al | 1993 | Transfion1993，，： | 1 |
| 14 | Nonablative laser skin resurfacing using a IS40nm erbium glass laser:A clinical and histologic analysis 显示文摘 | Lupton JR Williams CM AIster TS | 2002 | Dermatol Surg2002，28，9： | 1 |
| 15 | The identification of family members' contribution to patient'care in the intensive care unit: A naturalistic inquiry 显示文摘 | Williams CM | 2005 | Nurs Crit Care2005，10，1： | 1 |
| 16 | Comparison of disk dif-fusion ,Vitek 2,and broth microdilution antimicrobial susceptibilitytest results for unusual species of Enterobacteriaceae 显示文摘 | Stone ND 0 ’ Hara CM Williams PP | 2007 | J ClinMicrobiol2007，45，2： | 1 |
| 17 | Nonablative laser skin resurfacing using a 1540 nm erbium glass laser:A clinical and histologic analysis显示文摘 | Lupton JR Williams CM Alster TS | 2002 | Dermatol Surg2002，28，9： | 1 |
| 18 | Preparation of (-) epigallocatechin gallate from commercial green tea by caffeine precipitation and solvent partition显示文摘 | Copeland EL Clifford MN Williams CM | 1998 | Food Chem1998，61，： | 1 |
| 19 | Antibacterial role for natural killer cells in host defense toBacillus anthracis显示文摘 | Gonzales CM Williams CB Calderon VE | 2012 | Infect Immun2012，80，1： | 1 |
| 20 | Patterns of the hazard of death after AIDS through the evolution of antiretroviral therapy: 1984-2004显示文摘 | Schneider MF Gange S J Williams CM | 2005 | AIDS2005，19，17： | 1 |
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