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| 1 | Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection显示文摘Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components.Dendritic cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease severity.In this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory markers.Remarkably,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 infection.Moreover,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were observed.These findings contribute to a better understanding of the immunological sequelae of COVID-19. | Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero Javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica Alfaro-Lara Cristina Amodeo Javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez Esther Pérez Manuel Poyato Julia Praena-Segovia Rafaela Ríos Cristina Roca-Oporto Jesús F.Rodríguez María Jesús Rodríguez-Hernández Santiago Rodríguez-Suárez Ángel Rodríguez-Villodres Nieves Romero-Rodríguez Ricardo Ruiz Zida Ruiz de Azua Celia Salamanca Sonia Sánchez Víctor Manuel Sánchez-Montagut César Sotomayor Alejandro Suárez Benjumea Javier Toral | 2021 | Cellular & Molecular Immunology2021，18，9： | 2 |
| 2 | Influence of age in estimating maximal oxygen uptake显示文摘ObjectiveTo 在最大的氧举起的估计( EE )的错误上估计年龄的影响( VO 2最大)用性别和在自从估计,测试的周期测力计锻练特定方程的人口, VO 2最大与实质的 EE 被联系,经常超过20%, 18~91 年,可能,由于机械 efficiency.Methods1850 的内在的可变性,成年人(68%人)经历了最大的周期测力计测试的心肺的锻练。心和肺的健康(CRF ) 相对性别和年龄被估计[更年轻(18 ~ 35 年) ,中年(36 ~ 60 年) 并且更旧(>60 年)] 。VO 2 最大[mL·(kg· min )−1] 被对煤气的交换的评价直接测量并且估计了使用性别和人口特定方程。VO 2 最大和相关 EE 在三年龄特定、性特定的 groups.ResultsDirectly 测量的 VO 2 男人和女人的最大是 29.5 ±10.5 mL·(kg· min )−1 和 24.2 ±9.0 mL·(kg· min )−1(P <0.01 ) 。EE [mL·(kg· min ) 为男人和女人的 −1] 和百分比错误(% E ) 有类似的价值, 0.5 ±3.2 和 0.4 ±2.9 mL·(kg· min )−1, 和 − 0.8 ±13.1% 并且 − 1.7 ±15.4%(P >0.05 ) 分别地。分别地,为每个年龄组的 EE 和 % E 为男人:更年轻的 = 1.9 ±4.1 mL·(kg· min )−1 和 3.8 ±10.5% ,中年的 = 0.6 ±3.1 mL·(kg· min )−1 和 0.4 ±10.3% ,更旧的 =− 0.2 ±2.7 mL·(kg· min )−1 和 − 4.2 ±16.6%(P <0.01 ) ;并且为女人:更年轻的 = 1.2 ±3.1 mL·(kg· min )−1 和 2.7 ±10.0% ,中年的 = 0.7 ±2.8 mL·(kg· min )−1 和 0.5 ±11.1% ,更旧的 =-0.8 ±2.3 mL·(kg· min )−1 和 − 9.5 ±22.4%(P <0.01 ).ConclusionVO 2 最大在更年轻的年龄组被低估并且在老年组被过高估计。年龄显著地影响 VO 2 在男人和女人的最大并且当 CRF 用人口被估计时,应该被认为特定方程,而非直接测量了。 | Christina G de Souza Silva Barry A Franklin Daniel E Forman Claudio Gil S Araujo | 2016 | Journal of Geriatric Cardiology2016，13，2： | 2 |
| 3 | One-step transversal palatal distraction and maxillary repositioning:technical considerations,advantages,and long-term stability显示文摘 | Cortese A Savastano M Savastano G Claudio PP | | 0，，： | 1 |
| 4 | HCV genetic variability:from quasispecies evolution to genotype classification显示文摘 | Claudio A Domenico G Stefano D | 2009 | Future Microbiol2009，4，3： | 1 |
| 5 | Biorefining of softwoods using ethanol organosolv pulping:Preliminary evaluation of process streams for manufacture of fuel-grade ethanol and co-products 显示文摘 | PAN Xue-jun CLAUDIO A NEIL G | 2005 | Biotechnology and Bioengineering2005，90，4： | 1 |
| 6 | Aqueous biphasic systems: a boost brought about by using ionic liquids 显示文摘 | Freire M G Claudio A F M Araujo J M M | 2012 | Chemical Society Reviews2012，41，14： | 1 |
| 7 | Coutinho critical assessment of the formation of ionic-liquid-based aqueous two-phase systems in acidic media显示文摘 | CLAUDIO A F M FERREIRA A M SHAHRIARI S FREIRE M G JOAO A P | 2011 | J Phys Chem B2011，115，11： | 1 |
| 8 | Modeling the contribution of specific grinding pressure for the calculation of HPGR product size distribution 显示文摘 | Claudio L S Vladmir K A Leonard G A | 2009 | Minerals Engineering2009，22，78： | 1 |
| 9 | Effect of the pesticide 2,4-Dmicro-bial activity of the soil monitored by micocalorimetry显示文摘 | Alexandre G S P Claudio A | 2000 | Thermochimica Acta2000，349，： | 1 |
| 10 | Anaerobic capacity may not be determined by critical power model in elite table tennis players 显示文摘 | Alessandro M Zagatto Marcelo Papoti and Claudio A G | 2008 | Journal of Sports Science and Medicine2008，7，1： | 1 |
| 11 | Solid phase extraction of food contaminants using molecular imprinted polymers 显示文摘 | CLAUDIO B LAURA A CRISTINA G | 2007 | Anal Chim Acta2007，591，1： | 1 |
| 12 | Knowledge transfer and inter-firm relationships in industrial districts: the role of the leader firm 显示文摘 | CLAUDIO G GIOVANNI S VITO A | 1998 | Technovation1998，1，19： | 1 |
| 13 | Pigouvian Taxation in Tourism 显示文摘 | Claudio A G | 2003 | Environmental and Resource Economics2003，，3： | 1 |
| 14 | Performance of modified montmorillonite clay in mercury adsorption process and thermodynamic studies显示文摘 | Denis L G Claudio A Rubia R V | 2008 | Inorganic Chemistry Communications2008，11，1： | 1 |
| 15 | Performance of a vortex flow bioreactor for cultivation of CHO-K1 cells on microcarriers显示文摘 | Patricia A S Roberto C G Claudio A T S | 2011 | Process Biochemistry2011，46，： | 1 |
| 16 | Adsorption of mercury cation on chemically modified clay显示文摘 | Denis L G Rubia R V Claudio A | 2009 | Materials Research Bulletin2009，44，3： | 1 |
| 17 | Multifaceted impact of self-efficacy beliefs on academic functioning显示文摘 | BANDURA A CLAUDIO B CAPRARA G V | 1996 | Child Development1996，67，3： | 1 |
| 18 | Silylating agents grafted onto silica derived from leached chrysotile显示文摘 | Fonseca M G Oilveira A S Claudio A | 2001 | Journal of Colloid and Interface Science2001，240，2： | 1 |
| 19 | Knowledge transfer and inter tricts: the role of Amsterdam, 1999, -firm relationships in industrial dis- the leader firm 显示文摘 | Albino V Garavelli A Claudio Schiuma G | 1999 | Technovation1999，19，1： | 1 |
| 20 | Knowledge Transfer and Inter - Firm Relationships in Industrial Districts: The Role of the Leader Firm显示文摘 | Vito A A Claudio G Giovanni S | 1999 | Technovation1999，19，： | 1 |
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