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| 1 | Tight junctions in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer显示文摘Inflammatory bowel diseases are characterised by inflammation that compromises the integrity of the epithelial barrier. The intestinal epithelium is not only a static barrier but has evolved complex mechanisms to control and regulate bacterial interactions with the mucosal surface. Apical tight junction proteins are critical in the maintenance of epithelial barrier function and control of paracellular permeability. The characterisation of alterations in tight junction proteins as key players in epithelial barrier function in inflammatory bowel diseases is rapidly enhancing our understanding of critical mechanisms in disease pathogenesis as well as novel therapeutic opportunities. Here we give an overview of recent literature focusing on the role of tight junction proteins, in particular claudins, in inflammatory bowel diseases and inflammatory bowel disease associated colorectal cancer. | Jonathan Landy Emma Ronde Nick English Sue K Clark Ailsa L Hart Stella C Knight Paul J Ciclitira Hafid Omar Al-Hassi | 2016 | World Journal of Gastroenterology2016，22，11： | 39 |
| 2 | Reduction of Cancer Risk With an Oral Supplement of Selenium显示文摘The hypothesis that a dietary Supplement of selenium (Se) may reduce cancer risk was tested experimetally in humans. Patients with histories of basal/squarnous cell carcinomas of the skin were assigned randomly in double-blind fashion to dally oral supplements of either Seenriched yeast (200 μg Se/day), or a low-Se yeast placebo. A total of 1312 patients recruited in 1983-1990 were followed with regular dermatologic examinations through 1993 for a total of 8269 person-years of observation. Skin cancer diagnoses were confirmed histologically.Plasma Se concentration was determined at 6-12 months intervals. All deaths and patient-reported illnesses were recorded; reported cancers were confirmed and documented by consultation with the patient medical care providers. The results indicate that Se did not significantly affect the primary endpoints: incidences of recurrent basal/squarnous cell carcinomas of the skin. However, Setreatment was associated with reductions in several secondary endpoints:total mortality, mortality from all cancers combined, as well as the incidence of all cancers combined, lung cancer, colorectal cancer and prostate cancer. The consistencies of these associations over time, between study clinics and for the leading cancer sltes strongly suggests benefits of Se-supplementation for this cohort of patients, supporting the hypopthesis that supplemental Se can reduce cancer risk. Although Se did no shown protective effects against nonmelanoma skin cancers, the suggested reductions in risks to other frequent cancers demand further evaluation in well controlled cliflical intervention | G·F·COMBSJR L·C·CLARK 等 | 1997 | Biomedical and Environmental Sciences1997，10，2： | 21 |
| 3 | Frequent amplification of a chr19q13.41 microRNA polycistron in aggressive primitive neuroectodermal brain tumors显示文摘 | Li M Lee KF Lu Y Clarke I Shih D Eberhart C Collins VP Van Meter T Picard D Zhou L Boutros PC Modena P Liang ML Scherer SW Bouffet E Rutka JT Pomeroy SL Lau CC Taylor MD Gajjar A Dirks PB Hawkins CE Huang A. | 2009 | 中国神经肿瘤杂志2009，7，4： | 3 |
| 4 | Fixed abrasive diamond wire machining-part Ⅰ:process monitoring and wire tension force显示文摘 | Shih A J Hardin C W Lemaster R L McSpadden S B | 2003 | International Journal Machine Tools & Manufacture2003，43，： | 1 |
| 5 | Complete genomes of two clinical Staphylococcus aureus strains:evidence for the rapid evolution of virulence and drug resistance显示文摘 | Holden MT Feil EJ Lindsay JA Peacock SJ Day NP Enright MC Foster TJ Moore CE Hurst L Atkin R Barron A Bason N Bentley SD Chillingworth C Chillingworth T Churcher C Clark L Corton C Cronin A Doggett J Dowd L Feltwell T Hance Z Harris B Hauser H Holroyd S Jagels K James KD Lennard N Line A Mayes R Moule S Mungall K Ormond D Quail MA Rabbinowitsch E Rutherford K Sanders M Sharp S Simmonds M Stevens K Whitehead S Barrell BG Spratt BG Parkhill J | 2004 | Proc Natl Acad Sci USA2004，101，26： | 1 |
| 6 | Design, synthesis, and anfiviral activity of 2'-deoxy- 2'-fluoro-2'-C-methylcytidine, a potent inhibitor of hepatitis C virus replication显示文摘 | CLARK L J HOLLECKER L MASON C J | 2005 | J Med Chem2005，48，17： | 1 |
| 7 | Flight string models for aircraft fleeting and routing 显示文摘 | C Bamhart N L Boland L W Clarke | 1998 | Transportation Science1998，32，3： | 1 |
| 8 | The split-cavity oscillator: a high-power e-beam modulator and microwave source显示文摘 | Marder B M Clark M C Bacon L D | 1992 | IEEE Trans on Plasma Science1992，20，3： | 1 |
| 9 | Magnetically insulated transmission line oscillator显示文摘 | Clark M C Marder B M Bacon L D | 1988 | Appl Phys Lett1988，52，1： | 1 |
| 10 | Effects of a comprehensive school based asthma program on symptoms, parentmanagement, grades, and absenteeism显示文摘 | Clark N M Brown R Joseph C L | 2004 | Chest2004，29，125： | 1 |
| 11 | Energy Absorbed by Longitudinally Splitting a Tibialis Anterior Allograft:Implications for Double-Bundle Anterior Cruciate Ligament Reconstruction显示文摘 | Clark L Howard C Bisso LJ | 2010 | The Journal of Arthroscopic&Related Surgery2010，26，9： | 1 |
| 12 | Generalized potential of adult neural stem cells 显示文摘 | Johansson C B | 2000 | Science2000，288，： | 1 |
| 13 | DNA sequence analyses of the ribosomal spacer regions in the Triticeae 显示文摘 | McIntyre C L Clarke B C Appels R | 1988 | Plant Syst Evol1988，160，： | 1 |
| 14 | Basal insulin therapy in typy 2 diabates: 27 -week comparison of insulin glargine ( HOE901 ) and NPH insulin 显示文摘 | Rosenstock J Schwartz S L Clark C Jr | 2001 | Diabetes Care2001，24，11： | 1 |
| 15 | Transthoracic biphasic waveform defibrillation at very high and very low energies: a comparison with monophasic waveforms in an animal model of ventricular fibrillation 显示文摘 | Clark C B Zhang Y Davies L R | 2002 | Resuscitation2002，54，2： | 1 |
| 16 | 129/01a mice carrying a null mutation in PrP that abolishes mRNA production are developmentally normal显示文摘 | Manson J C Clarke A R Hooper M L | 1994 | Mol Neurobiol1994，8，： | 1 |
| 17 | Loose-coupling a cellular automata model and GIS:long-term urban growth prediction for San-Francisco and Washington,Batimore 显示文摘 | Clarke K C Gaydos L J | 1998 | International Journal of Geographical Information Science1998，30，： | 1 |
| 18 | Identi-fication of a neural stem cell in the adult mammalian central nervoussystem显示文摘 | Johansson C B Momma S Clarke D L | 1999 | Cell1999，96，1： | 1 |
| 19 | Role of clay minerals in oil-forming reactions显示文摘 | GEATCHES D L CLARK SJ GREENWELL H C | 2010 | J Phys Chern A2010，114，10： | 1 |
| 20 | Survival of mammals breathing organic liquids equilibrated with oxygen at atmospheric pressure显示文摘 | Clark L C Jr Gollan F | 1966 | Science1966，152，3730： | 1 |
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