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| 1 | Reduction of Cancer Risk With an Oral Supplement of Selenium显示文摘The hypothesis that a dietary Supplement of selenium (Se) may reduce cancer risk was tested experimetally in humans. Patients with histories of basal/squarnous cell carcinomas of the skin were assigned randomly in double-blind fashion to dally oral supplements of either Seenriched yeast (200 μg Se/day), or a low-Se yeast placebo. A total of 1312 patients recruited in 1983-1990 were followed with regular dermatologic examinations through 1993 for a total of 8269 person-years of observation. Skin cancer diagnoses were confirmed histologically.Plasma Se concentration was determined at 6-12 months intervals. All deaths and patient-reported illnesses were recorded; reported cancers were confirmed and documented by consultation with the patient medical care providers. The results indicate that Se did not significantly affect the primary endpoints: incidences of recurrent basal/squarnous cell carcinomas of the skin. However, Setreatment was associated with reductions in several secondary endpoints:total mortality, mortality from all cancers combined, as well as the incidence of all cancers combined, lung cancer, colorectal cancer and prostate cancer. The consistencies of these associations over time, between study clinics and for the leading cancer sltes strongly suggests benefits of Se-supplementation for this cohort of patients, supporting the hypopthesis that supplemental Se can reduce cancer risk. Although Se did no shown protective effects against nonmelanoma skin cancers, the suggested reductions in risks to other frequent cancers demand further evaluation in well controlled cliflical intervention | G·F·COMBSJR L·C·CLARK 等 | 1997 | Biomedical and Environmental Sciences1997，10，2： | 21 |
| 2 | Circular voided slab stiffness显示文摘 | ELLIOT G CLARK L A | 1982 | Journal of the Structural Division ASCE1982，108，11： | 2 |
| 3 | Prognostic factors and treatment decisions in axillary-node-negative breast cancer显示文摘 | MC GUIRE W L CLARK G M | 1992 | N En-gl J Med1992，326，26： | 1 |
| 4 | Estimation of tropical forest structural characteristics using large-footprint lidar显示文摘 | Jason B Drake Ralph O Dubayah David B Clark Robert G Knox J.Bryan Blair Michelle A Hofton Robin L Chazdon John F Weishampel Steve Prince | 2001 | Remote Sensing of Environment2001，，2： | 1 |
| 5 | Characteristics of NiTi Surface Alloys Formed by Electrospark Deposition显示文摘 | Wang R Clark R A | 1988 | Surface and Coatings Technology1988，36，12： | 1 |
| 6 | The effect of prestorage WBC reduction on the rates of febrile nonhemolytic transfusion reactions to platelet concentrates and RBC显示文摘 | YAZER M H PODLOSKKY L CLARKE G | 2004 | Transfusion2004，44，： | 1 |
| 7 | London in the European financial services industry: locational advantage and product complementarities显示文摘 | Clark G L | 2002 | Journal of Economic Geography2002，2，4： | 1 |
| 8 | Luminescence dating of loess from the Liujiapo section, central China显示文摘 | Musson F M Clarke M L Wintle A G | 1994 | Quaternary Science Reviews1994，13，： | 1 |
| 9 | London in the European financial services industry:locational advantage and product complementarities 显示文摘 | Clark G L | 2002 | Journal of Economic Geography2002，2，： | 1 |
| 10 | amifositine reduces side effects and improves complete response rale during radiotherapy:esults sf meta-analysis显示文摘 | Sasse A D Clark L G Sasse E C | 2006 | Int J Radiat Oncol Biol Phys2006，64，3： | 1 |
| 11 | 14-3-3 zeta negatively regulates Raf-1 activity by interactions with the Raf-1 cysteine-rich domain显示文摘 | Clark G J Drugan J K Rossmann K L | 1997 | Journal of Biological Chemistry1997，272，20： | 1 |
| 12 | Medical treatment for small abdominal aortic aneurysms 显示文摘 | Rughani G Robertson L Clarke M | 2012 | Cochrane Database Syst Rev2012，9，00： | 1 |
| 13 | Radiation modal expansion:application to active structural acoustic control显示文摘 | Gibbs G P Clark R L Cox D E | | 0，，01： | 1 |
| 14 | Spontaneous mutation rate of modifiers of metabolism in Drosophila显示文摘 | CLARK A G WANG L HULLEBERG T | 1995 | Genetics1995，139，： | 1 |
| 15 | Fluidization of moist sawdust in binary particle systems in a gassolid fluidized bed显示文摘 | Clarke K L Pugsley T Hill G A | 2005 | Chemical Engineering Science2005，60，24： | 1 |
| 16 | Passive oxygen in- sufflation is superior to bag-valve-mask ventilation for wit- nessed ventricular fibrillation out-of-hospital cardiac arrest 显示文摘 | Bobrow B J Ewy G A Clark L | 2009 | Ann Emerg Med2009，54，5： | 1 |
| 17 | The aireraft rotation problem 显示文摘 | Clarke L Johnson E Nemhauser G | 1997 | Annals of Operations Research1997，69，0： | 1 |
| 18 | Healing of an ulnar defect using a proprietary TCP bone graft substitute, JAX, in association with autologous osteogenic cells and growth factors 显示文摘 | Clarke S A Hoskins N L Jordan G R | 2007 | Bone2007，40，4： | 1 |
| 19 | Money flows like mercury: the geography of global finance显示文摘 | Clark G L | 2005 | Geografiska Annaler: Series B Human Geography2005，87，2： | 1 |
| 20 | L-Ascorbate biosynthesis in higher plants:the role of VTC2显示文摘 | LINSTER C L CLARKE S G | 2008 | Trends in Plant Science2008，13，： | 1 |
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