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| 1 | Relationship between adipose tissue dysfunction, vitamin D deficiency and the pathogenesis of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease worldwide.Its pathogenesis is complex and not yet fully understood.Over the years many studies have proposed various pathophysiological hypotheses,among which the currently most widely accepted is the'multiple parallel hits'theory.According to this model,lipid accumulation in the hepatocytes and insulin resistance increase the vulnerability of the liver to many factors that act in a coordinated and cooperative manner to promote hepatic injury,inflammation and fibrosis.Among these factors,adipose tissue dysfunction and subsequent chronic low grade inflammation play a crucial role.Recent studies have shown that vitamin D exerts an immune-regulating action on adipose tissue,and the growing wealth of epidemiological data is demonstrating that hypovitaminosis D is associated with both obesity and NAFLD.Furthermore,given the strong association between these conditions,current findings suggest that vitamin D may be involved in the relationship between adipose tissue dysfunction and NAFLD.The purpose of this review is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to adipose tissue dysfunction,and in the pathophysiology linking vitamin D deficiency with NAFLD and adiposity,together with an overview of the evidence available on the clinical utility of vitamin D supplementation in cases of NAFLD. | Flavia A Cimini Ilaria Barchetta Simone Carotti Laura Bertoccini Marco G Baroni Umberto Vespasiani-Gentilucci Maria-Gisella Cavallo Sergio Morini | 2017 | World Journal of Gastroenterology2017，23，19： | 9 |
| 2 | Overview of studies of the vitamin D/vitamin D receptor system in the development of non-alcoholic fatty liver disease显示文摘Non-alcoholic fatty liver disease(NAFLD)is the most common chronic liver disease in the world.NAFLD is known to be associated with obesity,type 2 diabetes,metabolic syndrome and increased cardiovascular events:for these reasons,it is becoming a global public health problem and represents an important challenge in terms of prevention and treatment.The mechanisms behind the pathogenesis of NAFLD are multiple and have not yet been completely unraveled;consequently,at moment there are not effective treatments.In the past few years a large body of evidence has been assembled that attributes an important role in hepatic aberrant fat accumulation,inflammation and fibrosis,to the vitamin D/vitamin D receptor(VD/VDR)axis,showing a strong association between hypovitaminosis D and the diagnosis of NAFLD.However,the data currently available,including clinical trials with VD supplementation,still provides a contrasting picture.The purpose of this editorial is to provide an overview of recent advances in the pathogenesis of NAFLD in relation to VD/VDR.Based on recent data from literature,we focused in particular on the hypothesis that VDR itself,independently from its traditional ligand VD,may have a crucial function in promoting hepatic fat accumulation.This might also offer new possibilities for future innovative therapeutic approaches in the management of NAFLD. | Flavia Agata Cimini Ilaria Barchetta Simone Carotti Sergio Morini Maria Gisella Cavallo | 2019 | World Journal of Gastrointestinal Pathophysiology2019，10，2： | 4 |
| 3 | Comparison of frequency offset estimation techniques for burst OFDM显示文摘 | Patel S Cimini L J McNair B | 2002 | Vehicular Technology Conference IEEE 55th2002，2，： | 2 |
| 4 | The emerging role of probiotics in neurodegenerative diseases:new hope for Parkinson’s disease?显示文摘Neurodegenerative disease etiology is still unclear,but different contributing factors,such as lifestyle and genetic factors are involved.Altered components of the gut could play a key role in the gut-brain axis,which is a bidirectional system between the central nervous system and the enteric nervous system.Variations in the composition of the gut microbiota and its function between healthy people and patients have been reported for a variety of human disorders comprising metabolic,autoimmune,cancer,and,notably,neurodegenerative disorders.Diet can alter the microbiota composition,affecting the gutbrain axis function.Different nutraceutical interventions have been devoted to normalizing gut microbiome dysbiosis and to improving biological outcomes in neurological conditions,including the use of probiotics.Preclinical and clinical investigations discussed in this review strengthen the correlation between intestinal microbiota and brain and the concept that modifying the microbiome composition may improve brain neurochemistry,modulating different pathways.This review will discuss the potential use of probiotics for Parkinson’s disease prevention or treatment or as adjuvant therapy,confirming that gut microbiota modulation influences different pro-survival pathways.Future investigations in Parkinson’s disease should consider the role of the gut-brain axis and additional comprehension of the underlying mechanisms is extremely necessary. | Vanessa Castelli Michele d’Angelo Massimiliano Quintiliani Elisabetta Benedetti Maria Grazia Cifone Annamaria Cimini | 2021 | Neural Regeneration Research2021，16，4： | 2 |
| 5 | Robust channel estimation for OFDM systems with rapid dispersive fading channels显示文摘 | Li Y Cimini Jr L J Sollenberger N R | 1998 | IEEE Trans Commun1998，46，7： | 2 |
| 6 | Power - efficient relay selection in cooperative networks using decentralized distributed space -time block coding显示文摘 | ZHANG Lu Leonard J Cimini Jr | 2008 | EURASIP Journal on Advances in Signal Processing2008，，9： | 1 |
| 7 | OFDM with diversity and coding for high-bit-rate mobile data applications显示文摘 | Sollenberger N R | 1997 | Mobile Multimedia Communications1997，，1： | 1 |
| 8 | Analysis and simulation of a digital mobile channel using orthogonal frequency division multiplexing显示文摘 | CIMINI L J | 1985 | IEEE Trans Commun1985，33，7： | 1 |
| 9 | Activated Vgamma9Vdelta2Tcells trigger granulocyte functions via MCP-2release显示文摘 | Agrati C Cimini E Sacchi A Bordoni V Gioia C Casetti R Turchi F Tripodi M Martini F | 2009 | J Immunol2009，182，1： | 1 |
| 10 | Analysis and simulation of a digital mobile channel using orthogonal frequency division multiplexing显示文摘 | CIMINI L J | 1985 | IEEE Trans Commun1985，33，： | 1 |
| 11 | MIMO radar with widly separated antennas显示文摘 | Haimovich A M Blum R S Cimini L J | 2008 | IEEE Signal Processing Maga- zine2008，1，25： | 1 |
| 12 | Robust channel estimation for OFDM systems with rapid dispersive fading channels 显示文摘 | Y Li L J Cimini N R Sollenberger | 1998 | IEEE Transactions on Communications1998，46，7： | 1 |
| 13 | Opportunistic beamforming and scheduling for OFDMA systems显示文摘 | SVEDMAN P WILSON S K CIMINI J | 2007 | IEEE Transactions on Communications2007，55，5： | 1 |
| 14 | Effects of clipping and filtering on the performance of OFDM 显示文摘 | Li X D Cimini L J | 1998 | IEEE Communications Letters1998，2，5： | 1 |
| 15 | Robust channel estimation for OFDM systems with rapid dispersive fading channels显示文摘 | Li Y(G) Cimini L J Jr Sollenberger N R | 1998 | IEEE Transactions on Communications1998，46，7： | 1 |
| 16 | Analysis and simulation of a digital mobile channel using orthogonal frequency division multiplexing显示文摘 | CIMINI L J | 1985 | IEEE Trans Commun1985，33，7： | 1 |
| 17 | Analysis and simulation of a digital mobile channel using orthogonal frequency division multiplexing 显示文摘 | CIMINI L J | 1985 | IEEE Trans Commun1985，33，： | 1 |
| 18 | Effect of Clipping and Filteringon the performance of OFDM显示文摘 | X Li L J Cimini | 1998 | IEEE Commun1998，，： | 1 |
| 19 | MIMO radar with widelyseparated antennas显示文摘 | Haimovich A M Blum R S Cimini L J | 2008 | IEEE Signal Processing Magazine2008，1，： | 1 |
| 20 | Merotelic kinetochore orientation,aneuploidy,and cancer显示文摘 | Cimini D | 2008 | Biochim Biophys Acta2008，1786，1： | 1 |
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