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| 1 | High-density SNP-based genetic maps for the parents of an outcrossed and a selfed tetraploid garden rose cross, inferred from admixed progeny using the 68k rose SNP array显示文摘Dense genetic maps create a base for QTL analysis of important traits and future implementation of marker-assisted breeding.In tetraploid rose,the existing linkage maps include<300 markers to cover 28 linkage groups(4 homologous sets of 7 chromosomes).Here we used the 68k WagRhSNP Axiom single-nucleotide polymorphism(SNP)array for rose,in combination with SNP dosage calling at the tetraploid level,to genotype offspring from the garden rose cultivar‘Red New Dawn’.The offspring proved to be not from a single bi-parental cross.In rose breeding,crosses with unintended parents occur regularly.We developed a strategy to separate progeny into putative populations,even while one of the parents was unknown,using principle component analysis on pairwise genetic distances based on sets of selected SNP markers that were homozygous,and therefore uninformative for one parent.One of the inferred populations was consistent with self-fertilization of‘Red New Dawn’.Subsequently,linkage maps were generated for a bi-parental and a self-pollinated population with‘Red New Dawn’as the common maternal parent.The densest map,for the selfed parent,had 1929 SNP markers on 25 linkage groups,covering 1765.5 cM at an average marker distance of 0.9 cM.Synteny with the strawberry(Fragaria vesca)genome was extensive.Rose ICM1 corresponded to F.vesca pseudochromosome 7(Fv7),ICM4 to Fv4,ICM5 to Fv3,ICM6 to Fv2 and ICM7 to Fv5.Rose ICM2 corresponded to parts of F.vesca pseudochromosomes 1 and 6,whereas ICM3 is syntenic to the remainder of Fv6. | Mirjana Vukosavljev Paul Arens Roeland E Voorrips Wendy P C van't Westende G D Esselink Peter M Bourke Peter Cox W Eric van de Weg Richard G F Visser Chris Maliepaard Marinus J M Smulders | 2016 | Horticulture Research2016，3，1： | 6 |
| 2 | On tolerability and safety of a maintenance treatment with 6-thioguanine in azathioprineor 6-mercaptopurine intolerant IBD patients显示文摘AIM: To determine the tolerability and safety profile of a low-dose maintenance therapy with 6-TG in azathioprine (AZA) or 6-mercaptopurine (6-MP) intolerant inflammatory bowel disease (IBD) patients over a treatment period of at least 1 year.METHODS: Database analysis.RESULTS: Twenty out of ninety-five (21%) patients discontinued 6-TG (mean dose 24.6 mg; mean 6-TGN level 540 pmol/8×108 RBC) within 1 year. Reasons for discontinuation were GI complaints (31%), malaise (15%)and hepatotoxicity (15%). Hematological events occurred in three patients, one discontinued treatment. In the 6-TG-tolerant group, 9% (7/75) could be classified as hepatotoxicity. An abdominal ultrasound was performed in 54% of patients, one patient had splenomegaly.CONCLUSION: The majority of AZA or 6-MP-intolerant IBD patients (79%) is able to tolerate maintenance treatment with 6-TG (dosages between 0.3 and 0.4 mg/kg per d). 6-TG may still be considered as an escape maintenance immunosuppressant in this difficult to treat group of patients, taking into account potential toxicity and efficacy of other alternatives. The recently reported hepatotoxicity is worrisome and 6-TG should therefore be administered only in prospective trials. | Nanne KH de Boer Luc JJ Derijks Lennard PL Gilissen Daniel W Hommes Leopold GJB Engels Sybrand Y de Boer Gijsbertus den Hartog Piet M Hooymans Anja BU M(?)kelburg Barend D Westerveld Anton HJ Naber Chris JJ Mulder Dirk J de Jong | 2005 | World Journal of Gastroenterology2005，11，35： | 4 |
| 3 | Continuous internal counterpulsation as a bridge to recovery in acute and chronic heart failure显示文摘Cardiac recovery from cardiogenic shock(CS) and end-stage chronic heart failure(HF) remains anoften insurmountable therapeutic challenge. The counterpulsation technique exerts numerous beneficial effects on systemic hemodynamics and left ventricular mechanoenergetics, rendering it attractive for promoting myocardial recovery in both acute and chronic HF. Although a recent clinical trial has questioned the clinical effectiveness of short-term hemodynamic support with intra-aortic balloon pump(IABP, the main representative of the counterpulsation technique) in CS complicating myocardial infarction, the issue remains open to further investigation. Moreover, preliminary data suggest that long-term IABP support in patients with end-stage HF is safe and may mediate recovery of left- or/and right-sided cardiac function, facilitating long-term weaning from mechanical support or enabling the application of other permanent, life-saving solutions. The potential of long-term counterpulsation could possibly be enhanced by implementation of novel, fully implantable counterpulsation devices. | Christos D Kontogiannis Konstantinos Malliaras Chris J Kapelios Jay W Mason John N Nanas | 2016 | World Journal of Transplantation2016，6，1： | 4 |
| 4 | New insights into magnetic derivatives for structural mapping显示文摘 | Verduzco B Fairhead J D G Chris M | 2004 | The Leading Edge2004，23，： | 1 |
| 5 | Use of supplementary cementing materials to increase the resistance to chloride ion penetration of concrete cured at elevated temperatures显示文摘 | RACHEL J D CHRIS A F JENNIFER N | 1994 | ACI Materials Journal1994，91，1： | 1 |
| 6 | Methane Line Pa- rameters in H ITRAN 显示文摘 | Brown L R Chris D Benner Champion J P | 2003 | Journal of Quantitative Specmscopy and Radiative Transfer2003，82，： | 1 |
| 7 | The ORION statement: guidelines for transparent reporting of outbreak reports and intervention studies of nosocomial infection显示文摘 | Sheldon P Stone Ben S Cooper Chris C Kibbler Barry D Cookson Jenny A Roberts Graham F Medley Georgia Duckworth Rosalind Lai Shah Ebrahim Erwin M Brown Phil J Wiffen Peter G Davey | 2007 | The Lancet Infectious Diseases2007，，4： | 1 |
| 8 | Pendular, funi- cular, and capillary bridges: results for two dimen- sions显示文摘 | Maria E D U Chris J L Michael J A | 1999 | Journal of Colloid and Interface Science1999，220，： | 1 |
| 9 | Digital receivers and transmitters using polyphase filter banks for wireless commu- nication ns 显示文摘 | FREDRIC J H CHRIS D MICHAEL R | 2003 | IEEE Transactions on Microwave Theory and Techniques2003，51，4： | 1 |
| 10 | A two dimen- sional study of the rupture of funicular liquid bridges 显示文摘 | Maria E D U Chris J L Michael J A | 2002 | Chemical Engineering Science2002，57，： | 1 |
| 11 | The apparent friction of granular fault gouge in sheared layers显示文摘 | Marone Chris J Sammis Charles G | 1994 | Journal of Geophysical Research1994，99，4： | 1 |
| 12 | Reduced lignin content and altered lignin composition in transgenic tobacco down-regulated in expression of L-phenylalanine ammonia-lyase or cinnamate 4-hydroxylase显示文摘 | Vincent J H S Weiting N Jack W B Hans G J Sameer A M Paul A H Chris L and Richard A D | | 0，，： | 1 |
| 13 | The apparent friction of granular fault gouge in sheared layers显示文摘 | Scott D R Marone Chris J Sammis Charles G | 1994 | Journal of Geophysical Research1994，99，4： | 1 |
| 14 | Reduced anisotropy of water diffusion in structural cerebral abnormalities demonstrated with diffusion tensor imaging显示文摘 | Udo C Wieshmann Chris A Clark Mark R Symms Florence Franconi Gareth J Barker Simon D Shorvon | 1999 | Magnetic Resonance Imaging1999，，9： | 1 |
| 15 | Native point defects in ZnO显示文摘 | Anderson J Chris G Van D W | 2007 | Phys Rev B2007，76，16： | 1 |
| 16 | Lipoprotein-associated phospholipase A2 as an independent predictor of coronary heart disease 显示文摘 | Chris J Packard D Denis S | 2000 | The New England Journal of Medicine2000，343，9： | 1 |
| 17 | Priee discrimination, competltion and regulation显示文摘 | Armstrong M Chris D Viekers J | 1993 | The Journal of industrial Economics1993，41，4： | 1 |
| 18 | Clinical evaluation of the Nucleus? 6 cochlear implant system: Performance improvements with SmartSound iQ显示文摘 | Stefan J Mauger Chris D Warren Michelle R Knight Michael Goorevich Esti Nel | 2014 | International Journal of Audiology2014，，8： | 1 |
| 19 | Synthesis and properties of waterborne self-crosslinkable sulfo-urethane silanol dispersions 显示文摘 | Kevin Lewandowski Larry R Krepski Daniel E Mickus Ralph R Roberts Steven M Heilmann Wayne K Larson Mark D Purgett Steven D Koecher Stephen A Johnson Daniel J Mcgurran Chris J Rueb Sadanand V Pathre Khalid A M Thakur | 2002 | Journal of Polymer Science Part A : Polymer Chemistry2002，40，17： | 1 |
| 20 | The application of postponement in industry 显示文摘 | YANG B NEIL D B CHRIS J B | 2005 | IEEE Transactions on Engineering Management2005，52，2： | 1 |
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