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| 1 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 2 | A New Approach for Efficient Rescheduling of Multi-product Batch Plants 显示文摘 | VIN J P IERAPETRIOU M G | 2000 | Ind Eng Chem Res2000，39，： | 1 |
| 3 | Generalized guaranteed rate-scheduling algorithms: a framework显示文摘 | Goyal P Vin H M | 1997 | IEEE/ACM Transactions on Networking1997，5，4： | 1 |
| 4 | Designing an on-demand multimedia service显示文摘 | RANGAN P V VIN H M RAMANATHAN S | 1992 | IEEE Communications Magazine1992，30，7： | 1 |
| 5 | Start-time fair queuing: a scheduling algorithm for integrated services显示文摘 | GOYAL P VIN H M CHEN H | 1997 | IEEE/ACM Transactions on Networking1997，5，5： | 1 |
| 6 | Luther Gulick on Frederick Taylor and Scientific Management 显示文摘 | PAUL P VIN R | 1995 | Journal of Manage- ment History ( Archive)1995，1，2： | 1 |
| 7 | Designing an On-Demand Multimedia Service显示文摘 | P V Rangan H Vin S Ramanathan | 1992 | IEEE Communication Magazine1992，30，7： | 1 |
| 8 | Efficient striping techniques for variable bit rate continuous media file servers 显示文摘 | SHENOY P VIN H M | 1999 | Performance Evaluation1999，38，3： | 1 |
| 9 | Designing a multiuser HDTV storage server显示文摘 | Vin H Rangan P | 1993 | IEEE Transactions on Selected Areas in Communications1993，11，1： | 1 |
| 10 | A process model for air bending显示文摘 | De Vin L J Streppel A H Singh U P | 1996 | Journal of Materials Processing Technology1996，57，12： | 1 |
| 11 | Efficient storage techniques for digital continuous multimedia 显示文摘 | P Venkat Rangan Harrick M Vin | 1993 | IEEE Transaction on Knowledge and Data Engineering1993，15，4： | 1 |
| 12 | Starttime fair queuing:a scheduling algorithm for integrated services packet switching networks显示文摘 | GOLESTANI P VIN H CHENG H | 1996 | Computer Communication Review1996，26，4： | 1 |
| 13 | Designing an on-demand multimedia service显示文摘 | Rangan P V Vin H M Ramanathan S | 1992 | IEEE Commun1992，30，7： | 1 |
| 14 | Techniques for Multimedia Synchronization in Network File Systems 显示文摘 | P Venkat Rangan Srinivas Ramanathan Harrick M Vin Thomas Kaeppner | 1993 | Computer Communications1993，16，3： | 1 |
| 15 | Designing an on-demand multimedia service 显示文摘 | Rangan P V Vin H M Ramanathan S | 1992 | IEEE Communications Magazine1992，30，7： | 1 |
| 16 | In vitro andin vivo reduction of erythrocyte sorbitor by ascorbic acid显示文摘 | Vins on JA Staretz ME Bose P | 1989 | Diabetes1989，38，12： | 1 |
| 17 | Novel HCV replication mouse model using human hepatocellular carcinoma xenografts显示文摘 | Gu e vin C Lamarre A Labonte P | 2009 | Antiviral Res2009，84，1： | 1 |
| 18 | Gold deposits obtained by pulse plating 显示文摘 | Vin cent B Bercot P Creusat G F | 1990 | Plating and Surface Finishing1990，25，12： | 1 |
| 19 | Size and branching effects on the fluorescence of benzylie dendrimers possessing one apigenin fluorophore at the core显示文摘 | Vins P Vermachova M Drasar P | 2013 | Tetrahedron2013，69，10： | 1 |
| 20 | Multimedia storage servers: a tutorial显示文摘 | Vin H M Kandlur D D Rangan P V and Rowe R A | 1995 | IEEE Computer Magazine1995，5，： | 1 |
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