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| 1 | 评估清晨或夜晚服用降压药对24h动态血压的影响:清晨或夜间服用降压药的希腊英国联合研究显示文摘观察数据显示,临床血压水平与随后的主要不良心血管事件之间存在强烈的线性关系。然而,动态血压监测显示,夜间血压水平比24h或白天血压水平更能预测主要的不良心血管事件。此外,夜间与白天的血压比值和杓型状态也是心血管结局的重要独立预测因素。这些发现可能对抗高血压药物的最佳给药时间有影响,一些研究表明,夜晚服用降压药可能较白天服药减少心血管事件。 | Poulter NR Savopoulos C Anjum A Apostolopoulou M Chapman N Cross M Falaschetti E Fotiadis S James RM Kanellos I Szigeti M Thom S Sever P Thompson D Hatzitolios AI 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，10： | 7 |
| 2 | Diagnosis and management of primary sclerosing cholangitis显示文摘 | Chapman R Fevery J Kalloo A | | Hepatology0，，： | 4 |
| 3 | Repeat endoscopic retrograde cholangiopancreaticography after failed initial precut sphincterotomy for biliary cannulation显示文摘AIM: To investigate the outcome of repeating endoscopic retrograde cholangiopancreaticography(ERCP) after initially failed precut sphincterotomy to achieve biliary cannulation.METHODS: In this retrospective study, consecutive ERCPs performed between January 2009 and September 2012 were included. Data from our endoscopy and radiology reporting databases were analysed for use of precut sphincterotomy, biliary access rate, repeat ERCP rate and complications. Patients with initially failed precut sphincterotomy were identified.RESULTS: From 1839 consecutive ERCPs, 187(10%) patients underwent a precut sphincterotomy during the initial ERCP in attempts to cannulate a native papilla. The initial precut was successful in 79/187(42%). ERCP was repeated in 89/108(82%) of patients with failed initial precut sphincterotomy after a median interval of 4 d, leading to successful biliary cannulation in 69/89(78%). In 5 patients a third ERCP was attempted(successful in 4 cases). Overall, repeat ERCP after failed precut at the index ERCP was successful in 73/89 patients(82%). Complications after precut-sphincterotomy were observed in 32/187(17%) patients including pancreatitis(13%), retroperitoneal perforations(1%), biliary sepsis(0.5%) and haemorrhage(3%).CONCLUSION: The high success rate of biliary cannulation in a second attempt ERCP justifies repeating ERCP within 2-7 d after unsuccessful precut sphincterotomy before more invasive approaches should be considered. | Michael Pavlides Ashley Barnabas Nilesh Fernandopulle Adam A Bailey Jane Collier Jane Phillips-Hughes Anthony Ellis Roger Chapman Barbara Braden | 2014 | World Journal of Gastroenterology2014，20，36： | 3 |
| 4 | Vemurafenib改善伴BRAF V600E突变的黑色素瘤患者的生存率显示文摘背景 BRAF激酶抑制剂vemurafenib(PLX4032)的1期和2期临床试验已证实其对伴BRAFV600E突变的转移性黑色素瘤患者的反应率超过50%。方法我们在675例既往未经治疗、伴BRAFV600E突变的转移性黑色素瘤患者中,实施了一项Ⅲ期随机化临床试验以比较vemurafenib和Dacarbazine(氮烯唑胺)。患者通过随机分配,分别接受vemurafenib(每次口服960mg,每天两次)或氮烯唑胺(每3周静脉注射1000mg·m-2体表面积)。本研究主要终点是比较总体生存率及无进展期生存率。次要终点包括反应率、反应持续时间以及安全性。计划在死亡98例患者时进行中期分析、死亡196例时进行最终分析。结果在治疗6个月后,vemurafenib组总体生存率为84%(95%置信区间[CI],78-89),而氮烯唑胺组为64%(95%CI,56-73)。在对总体生存率的中期分析及无进展期生存率的最终分析中,与氮烯唑胺相比,vemurafenib能相对减低63%的死亡风险,以及减低74%的死亡或者疾病进展风险(两种比较P<0.001)。通过数据及安全监督委员会进行独立中期分析审查后,建议氮烯唑胺组患者也转而服用vemurafenib。对Vemurafenib反应率是48%而氮烯唑胺只有5%。伴Vemurafenib常见不良反应为关节痛、皮疹、疲劳、脱发、角化棘皮瘤或鳞状细胞癌、光过敏、恶心和腹泻;38%的患者因为毒副作用要求调整剂量。结论 Vemurafenib能改善既往未经治疗、伴有BRAFV600E突变的黑色素瘤患者的总体及无进展期生存率。(本研究由瑞士罗氏制药有限公司资助;BRIM-3临床试验编号:NCT01006980) | 涂超 Chapman PB Hauschild A Robert C | 2011 | 肿瘤药学2011，1，5： | 2 |
| 5 | Evolving role of magnetic resonance techniques in primary sclerosing cholangitis显示文摘Development of non-invasive methods to risk-stratify patients and predict clinical endpoints have been identified as one of the key research priorities in primary sclerosing cholangitis(PSC). In addition to serum and histological biomarkers, there has been much recent interest in developing imaging biomarkers that can predict disease course and clinical outcomes in PSC.Magnetic resonance imaging/magnetic resonance cholangiopancreatography(MRI/MRCP) continue to play a central role in the diagnosis and follow-up of PSC patients. Magnetic resonance(MR) techniques have undergone significant advancement over the last three decades both in MR data acquisition and interpretation. The progression from a qualitative to quantitative approach in MR acquisition techniques and data interpretation, offers the opportunity for the development of objective and reproducible imaging biomarkers that can potentially be incorporated as an additional endpoint in clinical trials. This review article will discuss how the role of MR techniques have evolved over the last three decades from emerging as an alternative diagnostic tool to endoscopic retrograde cholangiopancreatography, to being instrumental in the ongoing search for imaging biomarker of disease stage, progression and prognosis in PSC. | Emmanuel A Selvaraj Emma L Culver Helen Bungay Adam Bailey Roger W Chapman Michael Pavlides | 2019 | World Journal of Gastroenterology2019，25，6： | 2 |
| 6 | Influence of temperature and vegetation cover on soluble inorganic and organic nitrogen in a spodosol显示文摘 | P.J Chapman B.L Williams A Hawkins | 2001 | Soil Biology and Biochemistry2001，，7： | 2 |
| 7 | X-ray focusing using microchannel plates I theory显示文摘 | Chapman H N Nugent K A Wilkins S W | 1993 | Appl Opt1993，32，： | 2 |
| 8 | Seasonal growth in Laminaria longicruris: Relations with dissolved inorganic nutrients and internal reserves of nitrogen显示文摘 | CHAPMAN A R O CRAIGIE J S | 1977 | Mar Biol (Berlin)1977，40，： | 2 |
| 9 | Morphological changes in the skin and wool fibres of Merino sheep infused with mouse epidermal growth factor 显示文摘 | Hollis D E Chapman R E Panaretto B A | 1983 | Aust J Biol Sci1983，36，4： | 1 |
| 10 | Premenopausal bone loss in the lumbar spine and neck of femur: A study of 225 Caucasian women 显示文摘 | Rodin A Murby B Smith MA Caleffi M Fentiman I Chapman MG Fogelman I | 1990 | Bone1990，，11： | 1 |
| 11 | Development of a regional climate model of the western Arctic 显示文摘 | Lynch A H Chapman W L Walsh J E | 1995 | Journal of Climate1995，8，： | 1 |
| 12 | Reflected Blast Wave Resultants Behind Cantilever Walls:A New Prediction Technique 显示文摘 | CHAPMAN T C ROSE T A SMITHS P D | 1995 | International Journal of Impact Engineering1995，16，3： | 1 |
| 13 | Removal of the fibrillar network surrounding Cichorium somatic embryos using cytoskeleton inhibitors: analysis of protein components显示文摘 | Chapman A Helleboid S Blervacq A S | 2000 | Plant Science2000，150，1： | 1 |
| 14 | Passive protection against infectious bursal disease virus by viral VP2 expressed in yeast显示文摘 | MACREADIE I G VAUGHAN P R CHAPMAN A J | 1990 | Vaccine1990，8，6： | 1 |
| 15 | The seedling establishment of rice under water in relating to temperature and dissolved oxygen显示文摘 | Chapman A L Peterson M L | 1962 | Crop Sci1962，2，： | 1 |
| 16 | Phase Ⅰ study of paclitaxel and estramustine:preliminary activity in hormone-refractory prostate cancer显示文摘 | Hudes G R Obasaju C Chapman A | 1995 | Semin Oncol1995，22，： | 1 |
| 17 | Surgical and radiological management of uterine fibroids in the UK显示文摘 | Chapman L Magos A | 2006 | Current Opinion Obstet Gynecol2006，18，4： | 1 |
| 18 | Pilot Ignited Premixed Combustion of Dimethyl Ether in a Turbo Diesel Engine 显示文摘 | CHAPMAN E M BOEHMAN A L | 2008 | Fuel Processing Technology2008，89，： | 1 |
| 19 | DNA binding- dependent and - independent functions of the Hand2 transcription factor during mouse embryogenesis显示文摘 | LIU N BARBOSA A C CHAPMAN S L | 2009 | Development2009，136，6： | 1 |
| 20 | Immunobiomarkers in small cell lung cancer: potential early cancer signals 显示文摘 | Chapman C J Thorpe AJ Murray A | 2011 | Clin Cancer Res2011，17，6： | 1 |
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