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| 1 | Differing profiles of people diagnosed with acute and chronic hepatitis B virus infection in British Columbia,Canada显示文摘AIM To describe the characteristics of people diagnosed with acute and chronic hepatitis B virus(HBV) infection in British Columbia(BC).METHODS We used data from the BC Hepatitis Testers Cohort(BCHTC),which includes all individuals tested for hepatitis C virus(HCV) or human immunodeficiency virus(HIV) or those diagnosed with HBV or active tuberculosis in BC since 1990.These data were integrated with prescription drug,medical visit,hospitalization and mortality data.HBV cases were classified as acute or chronic according to provincial guidelines.We compared characteristics of individuals by HBV infection group(acute,chronic and negative).Factors associated with acute or chronic HBV infection were assessed with multinomial logistic regression models in comparison to the HBV negative group.RESULTS46498 of the 1058056 eligible BC-HTC participants were diagnosed with HBV infection.4.3% of HBV positive individuals were diagnosed with acute HBV infections while 95.7% had chronic infections.Problematic alcohol use,injection drug use,and HIV or HCV co-infection were more common among individuals diagnosed with acute HBV compared to those with chronic infections and HBV negative individuals.In multivariable multinomial logistic regression models,we observed significant associations between acute or chronic HBV diagnosis and being male,age at HBV diagnosis or birth cohort,South and East Asian ethnicity,HCV or HIV infection,and injection drug use.The odds of acute HBV decreased with increasing age among people who inject drugs,while the opposite was true for chronic HBV.Persons with acute HBV were predominantly White(78%) while those with chronic HBV were mostly East Asian(60%).Relative to Whites,East Asians had 12 times greater odds of being diagnosed with chronic HBV infection.These odds increased with increasing socioeconomic deprivation.CONCLUSION Differences in the profiles of people diagnosed with acute and chronic HBV infection necessitate differentiated screening,prevention,care and treatment programs. | Mawuena Binka Zahid A Butt Stanley Wong Mei Chong Jane A Buxton Nuria Chapinal Amanda Yu Maria Alvarez Maryam Darvishian Jason Wong Gina McGowan Mikhail Torban Mark Gilbert Mark Tyndall Mel Krajden Naveed Z Janjua | 2018 | World Journal of Gastroenterology2018，24，11： | 3 |
| 2 | Harmonia axyridis(Pallas),the Third Species of the Genus to Be Found in the United States(Coleoptera:Coccinellidae)显示文摘 | Chapin J B Brou V A | 1991 | Proceedings of the Entomological Society Washington1991，93，： | 1 |
| 3 | Permafrostand the global carbon budget 显示文摘 | ZIMOV S A SCHUUR E A G CHAPIN III F S | 2006 | Science2006，312，： | 1 |
| 4 | Global biodiversity scenarios for the year 2100显示文摘 | Sala OE Chapin FS Ⅲ Armesto J J Berlow E Bloomfield J Dirzo R Huber-Sanwald E Huenneke LF Jackson RB Kinzig A Leemans R Lodge DM Mooney HA Oesterheld M Poff NL Sykes MT Walker BH Walker M Wall DH | | 0，，： | 1 |
| 5 | Resource limitation in plants : An economic analogy 显示文摘 | BLOOM A J CHAPIN F S MOONEY H A | 1985 | Annual Reviews of Ecology and Systematics1985，16，： | 1 |
| 6 | Changes in fetal lung distension alter expression of vascular endothelial growth factor and its isoforms in developing rat lung显示文摘 | Hara A Chapin CJ Ertsey R | 2005 | Pediatr Res2005，58，： | 1 |
| 7 | Permafrost and the global carbon budget显示文摘 | ZIMOV S A SCHUUR E A G CHAPIN F S | 2006 | Science2006，312，： | 1 |
| 8 | Permafrost and the globalcarbon budget显示文摘 | ZimovS A Schuur E A Chapin F S | 2006 | Science2006，312，5780： | 1 |
| 9 | The representation of Arctic soils in the Land Surface Model (LSM) : the impor- tance of mosses显示文摘 | Beringer J Lynch A H Chapin F S | 2001 | Journal of Climate2001，14，： | 1 |
| 10 | Resource limitation in plants-an economic analogy显示文摘 | BLOOM A J CHAPIN F S MOONEY H A | 1985 | Annual Reviews of Ecology and Systematics1985，16，： | 1 |
| 11 | Relationship between the structure of root systems and resource use for 11 North American grassland plants显示文摘 | Craine J M Wedin D A Chapin Ⅲ F S | 2002 | Plant Ecology2002，165，： | 1 |
| 12 | Response of arctic tundra to experimental and observed change in climate 显示文摘 | Chapin F S Ⅲ Shaver G R Goblin A E | 1995 | Ecology1995，76，： | 1 |
| 13 | Plant responses to multiple environmental factors显示文摘 | Chapin Ⅲ F S Bloom A J Field C B | 1987 | Bioscience1987，37，1： | 1 |
| 14 | Real-time control of a robot arm using simultaneously recorded neurons in the motor cortex显示文摘 | Chapin J K Moxon K A Markowitz R S | 1999 | Nature Neurosci1999，2，7： | 1 |
| 15 | Real-time prediction of hand trajectory by ensemblesof cortical neurons in primates显示文摘 | Wessberg J Stambaugh C R Kralik J D Beck P D Laubach M Chapin J K Kim J Biggs J Srinivasan M A Nicolelis M A L | 2000 | Nature2000，408，： | 1 |
| 16 | Plant responses to multiple environmental factors显示文摘 | Chapin FSIII Bloom A J Field C | 1987 | Bio Science1987，37，： | 1 |
| 17 | Predominance of ecophysiological controls on soil C02 flux in a Minnesota grassland显示文摘 | Craine J M Wedin D A Chapin F S | 1999 | Plant and Soil1999，207，： | 1 |
| 18 | Predominance of ecophysiological controls on soil CO_2 flux in a Minnesota grassland显示文摘 | CRAINE F M WEDIN D A CHAPIN Ⅲ F S | 1999 | Plant and Soil1999，207，： | 1 |
| 19 | Plant responses to multiple environmental factors显示文摘 | CHAPIN F S BLOOM I A J FIELD C B | 1987 | BioScience1987，37，1： | 1 |
| 20 | Responses of arctic tundra to experimental and observed changes in climate显示文摘 | Chapin F S Shaner III G R Giblin A E | 1995 | Ecology1995，，76： | 1 |
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