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| 1 | New insights into the vitamin D requirements during pregnancy显示文摘Pregnancy represents a dynamic period with physical and physiological changes in both the mother and her developing fetus. The dramatic 2–3 fold increase in the active hormone 1,25(OH)2 D concentrations during the early weeks of pregnancy despite minimal increased calcium demands during that time of gestation and which are sustained throughout pregnancy in both the mother and fetus suggests an immunomodulatory role in preventing fetal rejection by the mother. While there have been numerous observational studies that support the premise of vitamin D's role in maintaining maternal and fetal well-being, until recently, there have been few randomized clinical trials with vitamin D supplementation. One has to exhibit caution,however, even with RCTs, whose results can be problematic when analyzed on an intent-to-treat basis and when there is high non-adherence to protocol(as if often the case), thereby diluting the potential good or harm of a given treatment at higher doses. As such, a biomarker of a drug or in this case 'vitamin' or pre-prohormone is better served. For these reasons, the effect of vitamin D therapies using the biomarker circulating 25(OH)D is a far better indicator of true 'effect.' When pregnancy outcomes are analyzed using the biomarker 25(OH)D instead of treatment dose, there are notable differences in maternal and fetal outcomes across diverse racial/ethnic groups, with improved health in those women who attain a circulating25(OH)D concentration of at least 100 nmol · L-1(40 ng · m L-1). Because an important issue is the timing or initiation of vitamin D treatment/supplementation, and given the potential effect of vitamin D on placental gene expression and its effects on inflammation within the placenta, it appears crucial to start vitamin D treatment before placentation(and trophoblast invasion); however, this question remains unanswered.Additional work is needed to decipher the vitamin D requirements of pregnant women and the optimal timing of supplementation, taking into account a variety of lifestyles, body types, baseline vitamin D status,and maternal and fetal vitamin D receptor(VDR) and vitamin D binding protein(VDBP) genotypes.Determining the role of vitamin D in nonclassical, immune pathways continues to be a challenge that once answered will substantiate recommendations and public health policies. | Bruce W Hollis Carol L Wagner | 2017 | Bone Research2017，5，3： | 5 |
| 2 | Characterization of the antiviral effects of interferon-α against a SARS-like coronoavirus infection in vitro显示文摘 | Joanna Zorzitto Carole L Galligan Joanna JM Ueng Eleanor N Fish | 2006 | Cell Research2006，16，2： | 3 |
| 3 | 临床实践指南应当包含治疗负担显示文摘医疗方案的实施需要花费大量时间和精力,给慢性病患者带来巨大负担。然而,临床实践指南高度重视的是得到某些临床结果(如呼吸急促减少或存活率增加),传统指南的建议也是从同样角度提出的。最近的指南会考虑患者的价值观以及指南建议行为的可接受性和可行性,但对治疗负担没有明确规定。这使患者很难根据自己的价值观和能力对治疗做出明智的决定。 | Claudia C Dobler Nathan Harb Catherine A Maguire Carol L Armour Courtney Coleman M Hassan Murad 邓璇(译) 莫云凌(校) | 2019 | 英国医学杂志中文版2019，22，3： | 3 |
| 4 | Wheat bran tissue fractionation using biochemical markers显示文摘 | Carole Antoine Stéphane Peyron Valérie Lullien-Pellerin Jo?l Abecassis Xavier Rouau | 2004 | Journal of Cereal Science2004，，3： | 2 |
| 5 | Effect of ethanol on pro-apoptotic mechanisms in polarizedhepatic cells显示文摘Chronic ethanol consumption is associated with serious and potentially fatal alcohol-related liver injuries such as hepatomegaly, alcoholic hepatitis and cirrhosis. Moreover, it has been documented that the clinical progression of alcohol-induced liver damage may be associated with an increase in hepatocellular death that involves apoptotic mechanisms. Although much information has been learned about the clinical manifestations associated with alcohol-related diseases, the search continues for a better understanding of the molecular and/or cellular mechanisms by which ethanol exerts its deleterious effects such as the induction of pro-apoptotic mechanisms and related cell damaging events. As part of the effort to enhance our understanding of those particular cellular pathways and mechanisms associated with ethanol toxicity, researchers over the years have utilized a variety of model systems. Recently, work has come forth demonstrating the utility of a hybrid cell line (WIF-B) as a cell culture model system for the study of alcohol-associated alterations in hepatocellular mechanisms. Success with such emerging model systems could aid in the development of potential therapeutic treatments for the prevention of alcohol- induced apoptotic cell death that may ultimately serve as a significant target in delaying the onset and/or progression of clinical symptoms of alcohol-mediated liver disease. This review article summarizes the current understanding of ethanol-mediated modifications in cell survival and thus the promotion of pro-apoptotic events with emphasis on analyses made in various experimental model systems, particularly the more recently characterized WIF-B cell system. | Benita L McVicker Dean J Tuma Carol A Casey | 2007 | World Journal of Gastroenterology2007，13，37： | 2 |
| 6 | Impact of asialoglycoprotein receptor deficiency on the development of liver injury显示文摘The asialoglycoprotein (ASGP) receptor is a wellcharacterized hepatic receptor that is recycled via the common cellular process of receptor-mediated endocytosis (RME). The RME process plays an integral part in the proper traff icking and routing of receptors and ligands in the healthy cell. Thus, the missorting or altered transport of proteins during RME is thought to play a role in several diseases associated with hepatocyte and liver dysfunction. Previously, we examined in detail alterations that occur in hepatocellular RME and associated receptor functions as a result of one particular liver injury, alcoholic liver disease (ALD). The studies revealed profound ethanolmediated impairments to the ASGP receptor and the RME process, indicating the importance of this receptor and the maintenance of proper endocytic events in normal tissue. To further clarify these observations, studies were performed utilizing knockout mice (lacking a functional ASGP receptor) to which were administered several liver toxicants. In addition to alcohol, we examined the effects following administration of antiFas (CD95) antibody, carbon tetrachloride (CCl4) and lipopolysaccharide (LPS)/galactosamine. The results of these studies demonstrated that the knockout mice sustained enhanced liver injury in response to all of the treatments, as shown by increased indices of liver damage, such as enhancement of serum enzyme levels, histopathological scores, as well as hepatocellular death. Overall, the work completed to date suggests a possible link between hepatic receptors and liver injury. In particular, adequate function and content of the ASGP receptor may provide protection against various toxinmediated liver diseases. | Serene ML Lee Carol A Casey Benita L McVicker | 2009 | World Journal of Gastroenterology2009，15，10： | 2 |
| 7 | Severe Hand, Foot, and Mouth Disease Associated with Coxsackievirus A6 - Alabama, Connecticut, California, and Nevada, November 201 1 - February 2012显示文摘 | McIntyre Mary G Stevens Kelly M Davidson Sherri Pippin Tina Magill Dagny Kulhanjian Julie A Kelly Daniel Greenhow Tara L Salas Maria L Yagi Shigeo Padilla Tasha Berumen Ricardo Glaser Carol Landry Marie Louise Lott Jason Chen Lei Paulson | 2012 | EN2012，，12： | 2 |
| 8 | Cellular fi bronectin stimulates hepatocytes to produce factors that promote alcohol-induced liver injury显示文摘AIM:To examine the consequences of cellular f ibronectin(cFn)accumulation during alcohol-induced injury,and inv estigate whether increased cFn could have an effect on hepatocytes(HCs)by producing factors that could cont ribute to alcohol-induced liver injury.METHODS:HCs were isolated from rats fed a control or ethanol liquid diet for four to six weeks.Exogenous c Fn(up to 7.5 μg/mL)was added to cells cultured for 20 h,and viability(lactate dehydrogenase),apoptosis(caspase activity)and se cretion of proinflammat-ory cytokines(tumor ne c rosis fac tor alpha,TNF-α and interleukin 6,IL-6),mat rix metalloproteinases(MMPs)and their inhibitors(tissue inhibitors of metall-oproteinases,TIMPs)was det ermined.Degrad ation of iodinated cFn was det ermined over a 3 h time period in the preparations.RESULTS:cFn degradation is impaired in HCs isolated from ethanol-fed animals,leading to its accumulation in the matrix.Addition of exogenous cFn did not affect viability of HCs from control or ethanolfed animals,and apoptosis was affected only at the higher concentration.Sec retion of MMPs,TIMPs,TNF-α and IL-6,however,was increased by exogenously added cFn,with HCs from ethanolfed animals showing increased susceptibility compared to the controls.CONCLUSION:These results suggest that the elevated amounts of cFn observed in alcoholic liver injury can stimulate hepatocytes to produce factors which promote further tissue damage. | Razia S Aziz-Seible Benita L McVicker Kusum K Kharbanda Carol A Casey | 2011 | World Journal of Hepatology2011，3，2： | 2 |
| 9 | Organic acid and sugar contents of scuppernong grapes during ripening显示文摘 | Johnaon L A Caroll D E | 1973 | J of Food Sci1973，38，： | 1 |
| 10 | Using Office hours wisely 显示文摘 | JANA L PRESSLER CAROLE A KENNER | 2009 | Nurse Educator2009，，5： | 1 |
| 11 | Dynamics of MONOPTEROS and PIN-FORMED1 expression during leaf vein pattern formation in Arabido psis thaliana 显示文摘 | CAROL L W MATHIAS S QIAN YU | 2007 | The Plant Journal2007，49，3： | 1 |
| 12 | Train - The - Trainer Project meets organization 's strategic initiative for retention and continuous learning 显示文摘 | Carol AB Cheryl L Colleen MO | 2003 | Journal For Nurses in Staff Development2003，19，3： | 1 |
| 13 | Apolipoprotein A-I is necessary for the in vivo formation of high density lipoprotein competent for scavenger receptor BI-mediated cholesterol ester-selective uptake显示文摘 | Ryan E Temel Rosemary L Walzem Carole L | 2002 | J Biol Chem2002，277，26： | 1 |
| 14 | Comparison between different LiFePO4 synthesis routes and their influence on its physico-chemical properties显示文摘 | SLVSIN F FREDEREC L C CAROLE B HELENE R | 2003 | J Power Source2003，，： | 1 |
| 15 | Temkin vacuum electronics high power terahertz sources 显示文摘 | John H Booske Richard J Dobbs Colin D Joye Carol L Kory George R Neil Gunn-sik Park Jaehun Park Richard J | 2011 | IEEE transactions on terahertz science and technolo- gy2011，1，1： | 1 |
| 16 | Epilysin, a novel human matrix metallo-proteinase (MMP-28) expressed in testis and keratinocytes and in response to injury 显示文摘 | Lohi J Carole L Roby JD | 2001 | J Biol Chem2001，276，10： | 1 |
| 17 | External loops at the C terminus of Erwinia chrysanthemi pectate lyase C are required for species-specific secretion through the out type I pathway显示文摘 | Magdalen L Carol M B Noel T K0 | 1998 | J Bacteriol1998，180，6： | 1 |
| 18 | Synchonization in Chaotic Circuits显示文摘 | PECORA L M CAROLL T L | 1990 | Phys Rev Lett1990，64，8： | 1 |
| 19 | Cysteine protease gene expression and proteolytic activity during senescence of Alstroemeria petals显示文摘 | Carol W Michael K L Gareth G | 2002 | Journal of Experimental Botany2002，53，： | 1 |
| 20 | Expression of a single gene,BCL-6,strongly predicts survival in patients with diffuse large B-cell lymphoma显示文摘 | Izidore S L Carol D J Warnke R | 2001 | Blood2001，98，4： | 1 |
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