|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Soluble ST2:A new and promising activity marker in ulcerative colitis显示文摘AIM:To correlate circulating soluble ST2(sST2) levels with the severity of ulcerative colitis(UC) and serum levels of pro-inflammatory cytokines,and to demonstrate the predictive power of sST2 levels for differentiation between active and inactive UC.METHODS:We recruited 153 patients:82 with UC,26 with Crohn's disease(CD) and 43 disease controls [non-inflammatory bowel disease(IBD)].Subjects were excluded if they had diagnosis of asthma,autoimmune diseases or hypertension.The serum levels of sST2 and pro-inflammatory cytokines [pg/mL;median(25th-75th)] as well as clinical features,endoscopic and histological features,were subjected to analyses.The sST2 performance for discrimination between active and inactive UC,non-IBD and healthy controls(HC) was determined with regard to sensitivity and specificity,and Spearman's rank correlation coefficient(r).To validate the method,the area under the curve(AUC) of receiver-operator characteristic(ROC) was determined(AUC,95% CI) and the total ST2 content of the colonic mucosa in UC patients was correlated with circulating levels of sST2.RESULTS:The serum sST2 value was significantly higher in patients with active [235.80(90.65-367.90) pg/mL] rather than inactive UC [33.19(20.04-65.32) pg/mL],based on clinical,endoscopic and histopathological characteristics,as well as compared with non-IBD and HC(P < 0.001).The median level of sST2 in CD patients was 54.17(35.02-122.0) pg/mL,significantly higher than that of the HC group only(P < 0.01).The cutoff was set at 74.87 pg/mL to compare active with inactive UC in a multicenter cohort of patients.Values of sensitivity,specificity,and ability to correctly classify UC,according to activity,were 83.33%,83.33% and 83.33%,respectively.The AUC of the ROC curve to assess the ability of this molecule to discriminate between active vs inactive UC was 0.92(0.86-0.97,P < 0.0001).The serum levels of sST2 in patients with UC significantly correlated with endoscopic and histo-pathological scores(r = 0.76 and r = 0.67,P < 0.0001,respectively),and with the pro-inflammatory cytokine,tumor necrosis factor-α(r = 0.69 and r = 0.61,respectively,P < 0.0001).Interestingly,we found a direct correlation between total intestinal ST2 content and serum levels of sST2,adjusted to endoscopic activity score in patients with mild(r = 0.44,P = 0.004),moderate(r = 0.59,P = 0.002) and severe disease(r = 0.82,P = 0.002).Only patients with inactive UC showed no significant correlation(r = 0.45,P = 0.267).CONCLUSION:sST2 levels correlated with disease severity and inflammatory cytokines,are able to differentiate active from inactive UC and might have a role as a biomarker. | David Díaz-Jiménez Lucía E Núez Caroll J Beltrán Enzo Candia Cristóbal Suazo Manuel varez-Lobos María-Julieta González Marcela A Hermoso Rodrigo Quera | 2011 | World Journal of Gastroenterology2011，17，17： | 8 |
| 2 | Relationship between texture and pectin composition of two apple cultivars during storage显示文摘 | Ludivine Billy Emira Mehinagic Ga?lle Royer Catherine M.G.C. Renard Ga?lle Arvisenet Carole Prost Frédérique Jourjon | 2007 | Postharvest Biology and Technology2007，，3： | 3 |
| 3 | 用心脏的磁性的回声成像部分 1: 的心肌症的调查普通显型显示文摘 Cardiac magnetic resonance imaging(CMRI) has emerged as a useful tertiary imaging tool in the investigation of patients suspected of many different types of cardiomyopathies,CMRI sequences are now of a sufficiently robust quality to enable high spatial and temporal resolution image acquisition.This has led to CMRI becoming an effective non-invasive imaging gold standard for many cardiomyopathies.In this 2-part review,we outline the typical sequences used to image cardiomyopathy,and present the imaging spectrum of cardiomyopathy.Part 1 focuses on the current classification of cardiomyopathy,basic CMRI sequences used in evaluating cardiomyopathy and the imaging spectrum of common phenotypes. | Shaunagh McDermott Ailbhe C O’Neill Carole A Ridge Jonathan D Dodd | 2012 | World Journal of Cardiology2012，4，4： | 2 |
| 4 | Glyphosate toxicity and the effects of long - term vegetation control on soil microbial communities 显示文摘 | Busse Matt D Ratcliff Alice W Shestak Carol J Powers Robert F | 2001 | Soil Biology and Biochemistry2001，33，： | 2 |
| 5 | Organic acid and sugar contents of scuppernong grapes during ripening显示文摘 | Johnaon L A Caroll D E | 1973 | J of Food Sci1973，38，： | 1 |
| 6 | A role for nogo re- ceptor in macrophage clearance from injured peripheral nerve显示文摘 | Elizabeth JF Carole H Samuel D | 2007 | Neuron2007，53，5： | 1 |
| 7 | A Classroom Investigation: Can Video Improve Intermediate-Level French Language Students' Ability to Learn about a Foreign Culture? 显示文摘 | Carol H C Debastien D Steven C | 2002 | Modern Language Journal2002，，2： | 1 |
| 8 | A High - Throughput System for the Rapid Extraction of Plant Genomie DNA for Genome Mapping and Marker - Assisted Breeding Studies显示文摘 | Wang D H Song K M Carol K e t al | 2005 | Journal of the Association for Laboratory Automation2005，10，4： | 1 |
| 9 | Identification of an alternative CD20 transcript variant in B cell malignancies coding for a novel pro- tein associated to rituximab resistance 显示文摘 | Carole H Marina D Pierre - Simon R | 2010 | Blood2010，115，12： | 1 |
| 10 | Temkin vacuum electronics high power terahertz sources 显示文摘 | John H Booske Richard J Dobbs Colin D Joye Carol L Kory George R Neil Gunn-sik Park Jaehun Park Richard J | 2011 | IEEE transactions on terahertz science and technolo- gy2011，1，1： | 1 |
| 11 | Expression of a single gene,BCL-6,strongly predicts survival in patients with diffuse large B-cell lymphoma显示文摘 | Izidore S L Carol D J Warnke R | 2001 | Blood2001，98，4： | 1 |
| 12 | Liquefaction of Autographa californica Nucleopolyhedrovirus-Infected Insects Is Dependent on the Integrity of Virus-Encoded Chitinase and Cathepsin Genes显示文摘 | Rachael E Hawtin Tamara Zarkowska Kevin Arnold Carole J Thomas Graham W Gooday Linda A King John A Kuzio Robert D Possee | 1997 | Virology1997，，： | 1 |
| 13 | Recombinant Leishmania major Secreting Biologically Active Granulocyte-Macruphage Colony-Stimulating Factor Survives Poorly in Macrophages In Vitro and Delays Disease De-velopment in Mice 显示文摘 | Carole D Anthony M Ga6tan R | 2003 | Infection and Immunity2003，71，11： | 1 |
| 14 | Assessment of an immature platelet fraction (IPF) in peripheral thromhocytopenia显示文摘 | Carol B Kunka S Hart D | 2004 | British Journal of Haematology2004，126，： | 1 |
| 15 | Mutations in the Arabidopsis gene IMMUTANS cause a variegated phenotype by inactivating a chloroplast terminal oxidase associated with phytoene desaturation 显示文摘 | Carol P Stevenson D Bisanz C | 1999 | The Plant Cell1999，11，： | 1 |
| 16 | Neonatal damage to the rat's infraorbital primary afferent axons显示文摘 | Kathleen D Carol BC | 1996 | Exp Brain Res1996，112，： | 1 |
| 17 | An algal assay method for determination of copper complexation capacities of natural waters 显示文摘 | Herbert E A Carol B Thomas D B | 1983 | Bull Environ Contam Toxi- clo1983，30，： | 1 |
| 18 | DNA vaccines encoding viral glycoproteins induce nonspecific immunity and Mx protein synthesis in fish显示文摘 | Carol H K Marc C J John D D | 2000 | J Virol2000，74，15： | 1 |
| 19 | The Arabidopsis GAI gene defines a signaling pathway that negatively regulates gibber- ellin responses 显示文摘 | Peng J Carol P Richards D E | 1997 | Genes & Development1997，11，23： | 1 |
| 20 | Opportunities in the industrial biobased products industry显示文摘 | Carole T M Pellegrino J Paster M D | | 0，，04： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员