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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | Nitric oxide production during adjuvant-induced and collagen-induced arthritis显示文摘 | CANNON G W OPENSHAW S J HIBBS J B | 1996 | Arthritis Rheum1996，39，10： | 1 |
| 3 | Visual quality of residential streets: both street and yard trees make a difference显示文摘 | Schroeder H W W N Jr Cannon | 1987 | Arboric1987，13，10： | 1 |
| 4 | Creep of ceramics显示文摘 | W Roger Cannon Terence G Langdon | 1983 | Journalof Materials Science1983，18，1： | 1 |
| 5 | Effects of Merogel coverage on wound healing and ostial patency in endonasal endoscopic dacryoeystorhinostomy for primary chronic dacryoeystitis显示文摘 | Wu W Cannon PS Yah W | 2011 | Eye (Lond)2011，25，6： | 1 |
| 6 | Sulfate anion in water:model structural,thermodynamic,and dynamic properties显示文摘 | Cannon W R Pettitt B M McCammont J A | 1994 | Journal of Physical Chemistry1994，98，24： | 1 |
| 7 | Variability of temperature and currents measured near pipe organ hydrothermal vent site显示文摘 | Wetzler M A Lavelle J W Cannon G A | 1998 | Marine Geophysical Researches1998，20，： | 1 |
| 8 | Solar chimney cycle analysis with system loss and solar collector performance显示文摘 | Cannon A J Von Backstrom T W | 2000 | Journal of Solar Energy Engineering2000，122，： | 1 |
| 9 | Dy-namics of soil microbial biomass and water-soluble or- ganic C in Breton L alterS0 years of eropping to two rotations显示文摘 | MeGill W B Cannon K R Robertson J A | 1986 | Canadian Journal of Soil Science1986，66，1： | 1 |
| 10 | Review of the pest sta- tus and control options for Thrips palmi显示文摘 | Cannon R J C Matthews L Collins A D W | 2007 | Crop Protection2007，26，8： | 1 |
| 11 | Effects of merogel coverage onwound healing and ostial patency in endonasal endoscopic dacryocysto-rhinostomy for primary chronic dacryocystitis 显示文摘 | Wu W Cannon PS Yan W | 2011 | Eye ( Lond )2011，25，6： | 1 |
| 12 | Visual acuity recovery in traumatic optic neuropathy following endoscopic optic nerve decom- pression: a case report 显示文摘 | WU W SIA D I CANNON P S | 2011 | Ophthalmol Plast Reconstr Surg2011，27，1： | 1 |
| 13 | Colletotrichum: complex species or species complexes 显示文摘 | DAMM U CANNON P F CROUS P W | 2012 | Studies in Mycology2012，73，1： | 1 |
| 14 | Signal classification through multifraetal analysis and complex domain neural networks 显示文摘 | KINSNER W VINCENT C CANNONS K | 2006 | IEEE Transactions on Sys- tems Man and Cybernetic2006，36，2： | 1 |
| 15 | The absent bow tie sign in bucket handle tears of the menisci of the knee显示文摘 | Helms C A Laorr A Cannon W D | 1998 | AJR1998，170，： | 1 |
| 16 | Remission in rheumatoid arthritis patients treated with etanercept monotherapy , clinical practice and clinical trial experience显示文摘 | Cannon G W Wang B C Park G S | 2013 | Clin Exp Rheumatol2013，31，6： | 1 |
| 17 | Endoscopic assisted adenoidectomy显示文摘 | Cannon C R Replogle W H Schenk M P | 1999 | Otolaryngol Head Neck Surg1999，121，： | 1 |
| 18 | Metallogeny of the Midcontinent rift system of North America 显示文摘 | Nicholson S W Cannon W F Schulz K J | 1992 | Precambrian Re- search1992，58，14： | 1 |
| 19 | Crustal scale thrusting and origin of the Montreal River monocline - A 5 - km - thick cross section of the Midcontinent rift in northern Michigan and Wisconsin 显示文摘 | Cannon W F Petennan Z E Sims P K | 1993 | Tectonics1993，12，： | 1 |
| 20 | Improved sphincter contractility after allogenic muscle-derived progenitor cell injection into the denervated rat urethra 显示文摘 | Cannon T W Lee J Y Somogyi G | 2003 | Urology2003，62，5： | 1 |
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