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| 1 | Viral hepatitis prevalence in patients with active and latent tuberculosis显示文摘AIM: To assess the prevalence of hepatitis B virus(HBV) and hepatitis C virus(HCV) infection and association with drug induced liver injury(DILI) in patients undergoing anti-tuberculosis(TB) therapy.METHODS: Four hundred and twenty nine patients with newly diagnosed TB- either active disease or latent infection- who were due to commence antiTB therapy between September 2008 and May 2011 were included. These patients were prospectively tested for serological markers of HBV, HCV and human immunodeficiency virus(HIV) infections- hepatitis B core antigen(HBc Ag), hepatitis B surface antigen(HBs Ag), hepatitis B e antigen, Ig G and Ig M antibody to HBc Ag(anti-HBc), HCV Ig G antibody and HIV antibody using a combination of enzyme-linked immunosorbent assay, Western blot assay and polymerase chain reaction techniques. Patients were reviewed at least monthly during the TB treatment initiation phase. Liver function tests were measured prior to commencement of antiTB therapy and 2-4 wk later. Liver function tests were also performed at any time the patient had significant nausea, vomiting, rash, or felt non-specifically unwell. Fisher's exact test was used to measure significance in comparisons of proportions between groups. A P value of less than 0.05 was considered statistically significant.RESULTS: Of the 429 patients, 270(62.9%) had active TB disease and 159(37.1%) had latent TB infection. 61(14.2%) patients had isolated anti-HBc positivity, 11(2.6%) were also HBs Ag positive and 7(1.6%) were HCV-antibody positive. 16/270 patients with active TB disease compared to 2/159 patients with latent TB infection had markers of chronic viral hepatitis(HBs Ag or HCV antibody positive; P = 0.023). Similarly the proportion of HBs Ag positive patients were significantly greater in the active vs latent TB infection group(10/43 vs 1/29, P = 0.04). The prevalence of chronic HBV or HCV was significantly higher than the estimated United Kingdom prevalence of 0.3% for each. We found no association between DILI and presence of serological markers of HBV or HCV. Three(5.3%) patients with serological markers of HBV or HCV infection had DILI compared to 25(9.5%) patients without; P = 0.04.CONCLUSION: Viral hepatitis screening should be considered in TB patients. DILI risk was not increased in patients with HBV/HCV. | Hesam Ahmadi Nooredinvand David W Connell Mahmoud Asgheddi Mohammed Abdullah Marie O'Donoghue Louise Campbell Melissa I Wickremasinghe Ajit Lalvani Onn Min Kon Shahid A Khan | 2015 | World Journal of Gastroenterology2015，21，29： | 7 |
| 2 | Nonlinear behavior of concrete beams with hybrid FRP and stainless steel reinforcements显示文摘The full-range behavior of partially bonded, together with partially prestressed concrete beams containing fiber reinforced polymer (FRP) tendons and stainless steel reinforcing bars was simulated using a simplified theoretical model. The model assumes that a section in the beam has a trilinear moment—curvature relationship characterized by three particular points, initial cracking of concrete, yielding of non-prestressed steel, and crushing of concrete or rupturing of prestressing tendons. Predictions from the model were compared with the limited available test data, and a reasonable agreement was obtained. A detailed parametric study of the behavior of the prestressed concrete beams with hybrid FRP and stainless steel reinforcements was conducted. It can be concluded that the deformability of the beam can be enhanced by increasing the ultimate compressive strain of concrete, unbonded length of tendon, percentage of compressive reinforcement and partial prestress ratio, and decreasing the effective prestress in tendons, and increasing in ultimate compressive strain of concrete is the most efficient one. The deformability of the beam is almost directly proportional to the concrete ultimate strain provided the failure mode is concrete crushing, even though the concrete ultimate strain has less influence on the load-carrying capacity. | 方志 龚畅 杨剑 CAMPBELL T I | 2009 | Journal of Central South University2009，16，3： | 2 |
| 3 | Ceramics in Dentistry: Historical Roots and Current Perspectives显示文摘 | Kelly J R Nishimura I Campbell S D | 1996 | J Prosthet Dent1996，75，： | 1 |
| 4 | SH3 Domains: Molecular 'Velcro' 显示文摘 | Morton C J Campbell I D | 1994 | Curr Biol1994，4，7： | 1 |
| 5 | Detecting and reducing hospital adverse events : outcomes of the wimmera clinical risk management program显示文摘 | Wolf A Bourke J Campbell I | 2001 | MJA2001，174，： | 1 |
| 6 | New advances in somatic cell nuclear transfer: application in transgenesis 显示文摘 | Polejaeva I A Campbell K H S | 2000 | Theriogenology2000，53，1： | 1 |
| 7 | Phosphorus clusters:synthesis in the gas-phase and possible cagelike and chain structures显示文摘 | Bulgakov A V Bobrenok O F Kosyakov V I Pzerov I Marine W Hed~n M Rohmund F Campbell E E B | | 0，，： | 1 |
| 8 | The role of engrailed in establishing the dorsoventral axis of the chick limb 显示文摘 | Logan C Hornbruch A Campbell I | 1997 | Development1997，124，12： | 1 |
| 9 | Cytokines and chemokines as mediators of protection and injury in the central nervous system assessed in transgenic mice 显示文摘 | Wang J Asensio V C Campbell I L | 2002 | Curr Top Microbiol Immunol2002，265，： | 1 |
| 10 | The stromal cell-derived factor-lalpha/CXCR4 ligand-receptot axis is critical for progenitor survival and migration in the pancreas显示文摘 | KAYALI A G VAN GUNST K CAMPBELL I L | 2003 | J Cell Biol2003，163，4： | 1 |
| 11 | Nematic 2, 5-disubstituted thiophenes 显示文摘 | Neil L Campbell Warren L Duffy Gareth I Thomas | 2002 | J Mater Chem2002，12，： | 1 |
| 12 | Embryonic and somatic cell cloning显示文摘 | Young L Campbell KH | 1998 | Reprod Fertil Dev1998，10，： | 1 |
| 13 | An expression for land surface water storage monitoring using a two-formation geological weighing lysimeter 显示文摘 | Bardsley W E Campbell D I | 2007 | Journal of Hydrology2007，335，： | 1 |
| 14 | Influence of nonprestressed reinforcement on the strength of unbonded partially prestressed concrete members显示文摘 | CAMPBELL T I CHOUINARD K L | 1991 | ACI Structural Journal1991，88，5： | 1 |
| 15 | Hypericin content variation in Hypericum perforatum in Australia显示文摘 | Southwell I A Campbell M H | 1991 | Phytochemistry1991，30，： | 1 |
| 16 | Zircon Ce^4+/Ce^3+ ratios and ages for Yulong ore-bearing por- phyries in eastern Tibet显示文摘 | Liang Huaying Campbell I H Allen C Sun Weidong Liu Congqiang Yu Hengxiang Xie Yingwen Zhang Yuqiang | 2006 | Miner Deposita2006，41，2： | 1 |
| 17 | Sleep deprivation impairs long-term potentiation in rat hippocampal slices显示文摘 | Campbell I G Guinan M J Horowitz J M | | 0，，02： | 1 |
| 18 | Spatial pattern,regeneration and growth rates of Brachystegia spiciformis and Julbernardia globiflora显示文摘 | Grundy I Campbell B Frost P | | 0，，： | 1 |
| 19 | Implications of mantle plume structure for the evolution of flood basalts显示文摘 | Campbell I H Griffiths R W | 1990 | Earth Planet Sci Lett1990，99，： | 1 |
| 20 | The effects of microcrystal size and shape on the phonon raman spectra of crystalline semiconductors显示文摘 | CAMPBELL I H FAUCHET P M | 1986 | Soli Stat Comm1986，58，10： | 1 |
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