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	题名	作者	年代	出处	被引量
1	Tenecteplase Reperfusion therapy in Acute ischaemic Cerebrovascular Events-Ⅱ (TRACE Ⅱ): rationale and design显示文摘Background and purpose Tenecteplase(TNK)is a promising agent for treatment of acute ischaemic stroke(AIS).We hypothesised that recombinant human TNK tissue-type plasminogen activator(rhTNK-tPA)is non-inferior to rt-PA in achieving excellent functional outcome at 90 days,when administered within 4.5 hours of ischaemic stroke onset.Methods and design Tenecteplase Reperfusion therapy in Acute ischemic Cerebrovascular Events(TRACE)is a phase Ⅲ,multicentre,prospective,randomised,open-label,blinded-end point non-inferiority study.Patients eligible for intravenous thrombolysis therapy are randomised to rhTNK-tPA 0.25 mg/kg(single bolus)to a maximum of 25 mg or rt-PA 0.9 mg/kg(10%bolus+90%infusion/1 hour)to a maximum of 90 mg.Medications considered necessary for the patient’s health may be given at the discretion of the investigator during 90-day follow-up.Study outcomes The primary study outcome is excellent functional outcome defined as modified Rankin Scale(mRS)0–1 at 90 days.Secondary efficacy outcomes include favourable functional outcome defined as mRS≤2 at 90 days,ordinal distribution of mRS and major neurological improvement on the National Institutes of Health Stroke Scale.Safety outcomes are symptomatic intracranial haemorrhage within 36 hours and death from any cause.Discussion There is no completed registration study of TNK in AIS worldwide.TRACE Ⅱ strives to provide evidence for a new drug application for rhTNK-tPA in AIS within 4.5 hours through a well-designed and rigorously executed randomised trial in China.	Shuya Li Bruce C V Campbell Lee H Schwamm Marc Fisher Mark Parsons Hao Li Yuesong Pan Yongjun Wang	2022	Stroke & Vascular Neurology2022，7，1：	2
2	Sludge management-future issues and trends显示文摘		2000	Wat Sci Tech2000，41，8：	1
3	The Yin and Yang of vitamin D receptor(VDR) signaling in neoplastic progression:operational networks and tissue-specific growth control显示文摘	CAMPBELL F C XU H EL-TANANI M	2010	Biochem Pharmacol2010，79，1：	1
4	Ex situ Evaluation of Tungsten Oxide as a Catalyst Support for PEMFCs 显示文摘	Chhina H Campbell S Keslerc O	2007	J Electrochem Soc2007，154，：	1
5	A dominant repression domain in Tbx3 mediates transcriptional repression and cell immortalization: relevance to mutations in Tbx3 that cause ulnar-mammary syndrome显示文摘	Carlson H Ota S Campbell C E	2001	Hum Mol Genet2001，10，21：	1
6	The end of cheap oil显示文摘	CAMPBEL C J LAHERRERE J H	1998	Sci Am1998，，3：	1
7	The cytosolic loop of the gamma -secretase component presenilin enhancer 2 (PeN-2) protects zebrafish embryos from apoptosis显示文摘	Zetterberg H Campbell W A Yang H W	2006	J Biol Chem2006，281，11：	1
8	New advances in somatic cell nuclear transfer: application in transgenesis 显示文摘	Polejaeva I A Campbell K H S	2000	Theriogenology2000，53，1：	1
9	Fcmale relatives or friends trainds as labor doulas:Outcomes at 6 to 8 weeks postparturn显示文摘	Campbell D Scott K D Klaus M H	2007	Birth2007，34，3：	1
10	Premature birth and low birth weight associated with nonautoimmune hyperthyroidism to an activating thyrotropin receptor gene mutation显示文摘	Vaidya B Campbell V Trioo J H	2004	Clin Endocrinol (Oxf)2004，60，6：	1
11	Mea- suring internal electric fields in organic light - emitting diodes using electroabsorption spectroscopy 显示文摘	CAMPBELL LAN H FERRARIS J P HAGLER T W	1997	Polym Advan Technol1997，8，：	1
12	The in fluence of cytokinins in nitrate regulation of nitrate reductase activ ity and expression in barley 显示文摘	SAMUELSON M E CAMPBELL W H LARASSON C M	1995	Physiologia Plantarum1995，93，：	1
13	Business economic impacts~ The new frontier for corporate accountability显示文摘	Campbell H	2005	Development in Practice2005，15，3：	1
14	Soil microbial and biochemical properties after ten years of fertilization with urea and anhydrous ammonia 显示文摘	Biederbeck V O Campbell C A Ukrainetz H	1996	Can J Soil Sci1996，76，1：	1
15	The development of Chlamydia trachomatis inclusions within the host eukaryotic cell during interphase and misosis显示文摘	Mine H	1989	J Gen Microhiol1989，135，：	1
16	Relativisitie Hartree-Slater values for K and L-ray emission rates显示文摘	CAMPBELL J H	2003	At Data Nucl Data Tables2003，85，：	1
17	Alpha and beta thalassemia 显示文摘	Muncie H L J r Campbell J	2009	Am Fam Physician2009，80，4：	1
18	Modification of lignin biosynthesis in transgenic Nicotiana through expression of an antisense O-methyltransferase gene from Populus显示文摘	Dwivedi U N Campbell W H Yu J	1994	Plant Mo Bio1994，26，：	1
19	Hypericin content variation in Hypericum perforatum in Australia显示文摘	Southwell I A Campbell M H	1991	Phytochemistry1991，30，：	1
20	The retardation of pro- tein denaturation by hydrostatic pressure 显示文摘	Johnson F H Campbell D H	1945	Journal of Cellular and Comparative Physiology1945，26，1：	1

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