|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Relationship between Th17 immune response and cancer显示文摘Cancer is the second leading cause of death worldwide and epidemiological projections predict growing cancer mortality rates in the next decades.Cancer has a close relationship with the immune system and,although Th17 cells are known to play roles in the immune response against microorganisms and in autoimmunity,studies have emphasized their roles in cancer pathogenesis.The Th17 immune response profile is involved in several types of cancer including urogenital,respiratory,gastrointestinal,and skin cancers.This type of immune response exerts pro and antitumor functions through several mechanisms,depending on the context of each tumor,including the protumor angiogenesis and exhaustion of T cells and the antitumor recruitment of T cells and neutrophils to the tumor microenvironment.Among other factors,the paradoxical behavior of Th17 cells in this setting has been attributed to its plasticity potential,which makes possible their conversion into other types of T cells such as Th17/Treg and Th17/Th1 cells.Interleukin(IL)-17 stands out among Th17-related cytokines since it modulates pathways and interacts with other cell profiles in the tumor microenvironment,which allow Th17 cells to prevail in tumors.Moreover,the IL-17 is able to mediate pro and antitumor processes that influence the development and progression of various cancers,being associated with variable clinical outcomes.The understanding of the relationship between the Th17 immune response and cancer as well as the singularities of carcinogenic processes in each type of tumor is crucial for the identification of new therapeutic targets. | Hanna Santos Marques Breno Bittencourt de Brito Filipe Antônio França da Silva Maria Luísa Cordeiro Santos Júlio César Braga de Souza Thiago Macêdo Lopes Correia Luana Weber Lopes Nayara Silva de Macêdo Neres Rafael Santos Dantas Miranda Dórea Anna Carolina Saúde Dantas Lorena Lôbo Brito Morbeck Iasmin Souza Lima Amanda Alves de Almeida Maiara Raulina de Jesus Dias Fabrício Freire de Melo | 2021 | World Journal of Clinical Oncology2021，12，10： | 5 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Antiherpetic activity of a sulfated polysaccharide from Agaricus brasiliensis mycelia显示文摘 | Francielle Tramontini Gomes de Sousa Cardozo Carla Maísa Camelini Alessandra Mascarello Márcio José Rossi Ricardo José Nunes Célia Regina Monte Barardi Margarida Matos de Mendon?a Cláudia Maria Oliveira Sim?es | 2011 | Antiviral Research2011，，1： | 2 |
| 4 | Amplification of an invA gene sequence of Salmonella typhimurium by polymerase chain reaction as a specific method of detection of Salmonella显示文摘 | Rahn K De Grandis SA Clarke RC McEwen SA Galan JE Ginocchio C | 1992 | Mol Cell Probes1992，6，4： | 1 |
| 5 | Mlgrove syndrome in adulthood 显示文摘 | Bentes C Santos-Bento M de Sa J | 2001 | Muscle Nerve2001，24，2： | 1 |
| 6 | Organic matter dynamics and carbon sequestration rates for a tillage chronosequence in a Brizilian Oxisol显示文摘 | De M Sa J C Cerri J C Dick C C | 2001 | Soil Science Society of America Journal2001，65，： | 1 |
| 7 | Development of Effervescent Tablets Containing Benznidazole Complexed with Cyclodextrin显示文摘 | MAXIMIANO F P COSTA G H Y DE SA BARRETO L C L | 2011 | Journal of Pharmacy and Pharmacology2011，63，6： | 1 |
| 8 | Soil organic matter pools and carbon-protection mechanisms in aggregate classes influenced by surface liming in a notall system显示文摘 | Briedis C Caires E F de Moraes Sa J C | 2012 | Geoderma2012，170，： | 1 |
| 9 | Introduction of digestive a-amylase in larvae of Zabrotes subfasciatus (Coleoptera: Bruchidae) in response to ingestion of common bean a-amylase inhibitor 显示文摘 | Silva C P Terra W R de Sa M F G Samuels R I | 2001 | Journal of Insect Physiology2001，47，： | 1 |
| 10 | Autophagy regulates IL-23 secretion and innate T cell responses through effects on IL-1 secretion显示文摘 | Peral de Castro C Jones SA Ni Cheallaigh C | 2012 | J Immunol2012，189，8： | 1 |
| 11 | Relative importance of comorbid psychologi- cal symptoms in patients with depressive symptom sfollowing phase II car- diac rehabilitation显示文摘 | De SA Lavie C J Milani RV | 2011 | Postgrad Med2011，123，6： | 1 |
| 12 | Epidemiologicat trends of infective endocarditis: a population-based study in Olmsted County, Minnesota显示文摘 | de Sa DD C Tleyjeh IM Anavekar NS | 2010 | Mayo Clin Proc2010，85，5： | 1 |
| 13 | The poly (A)-binding protein facilitates in vitro translation of poly(A)- rich mRNA显示文摘 | Grossi de Sa MF Standart N Martins de Sa C | 1988 | Eur J Biochem1988，176，3： | 1 |
| 14 | Prenatal sex hormone effects on child and adult sex- types behaviour: methods and findings 显示文摘 | Cohen-Bendahan CC van de Beek C Berenbaum SA | 2005 | Neurosci Biobehav Rev2005，29，2： | 1 |
| 15 | Immune-correlates analysis of an HIV-1 vaccine efficacy trial 显示文摘 | Haynes BF Gilbert PB McElrath MJ Zolla-Pazner S Tomaras GD Alam SM Evans DT Montefiori DC Kar- nasuta C Sutthent R Liao HX DeVico AL Lewis GK Williams C Pinter A Fong Y Janes H DeCamp A Huang Y Rao M Billings E Karasavvas N Robb ML Ngauy V de Souza MS Paris R Ferrari G Bailer RT Soderberg KA Andrews C Berman PW Frahm N De Ro- sa SC Alpert MD Yates NL Shen X Koup RA Pitisut- tithum P Kaewkungwal J Nitayaphan S Rerks-Ngarm S Michael NL Kim JH | 2012 | N Engl J Med2012，366，14： | 1 |
| 16 | Early recovery of pul- monary vein conduction after cryoballoon ablation for paroxysmal atrial fibrilla- tion : a prospective study 显示文摘 | Chierchia GB de Asmundis C Muller-Burri SA | 2009 | Europace2009，11，： | 1 |
| 17 | Choles terol transport from late endosomes to the Golgi regulates t-SNARE trafficking, assembty, and function显示文摘 | Reverter M Rentero C Vila de Muga SA | 2011 | Mol Blot Cetl2011，22，21： | 1 |
| 18 | Human papillomavirus genotype attribution in invasive cervical cancer:a retrospective cross-sectional worldwide study显示文摘 | de Sanjose S Quint WG Alemany L Geraets DT Klaustermeier JE Lloveras B Tous S Felix A Bravo LE Shin HR Vallejos CS de Ruiz PA Lima MA Guimera N Clavero O Alejo M Llombart-Bosch A Cheng-Yang C Tatti SA Kasamatsu E Iljazovic E Odida M Prado R Seoud M Grce M Usubutun A Jain A Suarez GA Lombardi LE Banjo A Menéndez C Domingo EJ Velasco J Nessa A Chichareon SC Qiao YL Lerma E Garland SM Sasagawa T Ferrera A Hammouda D Mariani L Pelayo A Steiner I Oliva E Meijer CJ AlJassar WF Cruz E Wright TC Puras A Llave CL Tzardi M Agorastos T Garcia-Barriola V Clavel C Ordi J Andújar M Castellsagué X Sánchez GI Nowakowsld AM Bornstein J Mu(n)oz N Bosch FX Retrospective International Survey and HPV Time Trends Study Group | 2010 | Lancet Oncol2010，11，11： | 1 |
| 19 | Neuroimaging of ischemia and infarction显示文摘 | Erica C Sa′de Camargo Walter J | 2005 | The Journal of the American Society for Experimental NeuroTherapeutics2005，2，： | 1 |
| 20 | Interplay of magnetism and superconductivity at the nanometer scale:the case of complex oxide heterostructures显示文摘 | Sa de Melo C A R | 2003 | Physica C2003，387，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员