|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mesenchymal stem cells: Molecular characteristics and clinical applications显示文摘Mesenchymal stem cells (MSCs) are non-hematopoietic stem cells with the capacity to differentiate into tissues of both mesenchymal and non-mesenchymal origin. MSCs can differentiate into osteoblastic, chondrogenic, and adipogenic lineages, although recent studies have demonstrated that MSCs are also able to differentiate into other lineages, including neuronal and cardiomyogenic lineages. Since their original isolation from the bone marrow, MSCs have been successfully harvested from many other tissues. Their ease of isolation and ex vivo expansion combined with their immunoprivileged nature has made these cells popular candidates for stem cell therapies. These cells have the potential to alter disease pathophysiology through many modalities including cytokine secretion, capacity to differentiate along various lineages, immune modulation and direct cell-cell interaction with diseased tissue. Here we first review basic features of MSC biology including MSC characteristics in culture, homing mechanisms, differentiation capabilities and immune modulation. We then highlight some in vivo and clinical evidence supporting the therapeutic roles of MSCs and their uses in orthopedic, autoimmune, and ischemic disorders. | Farbod Rastegar Deana Shenaq Eric R Wagner Stephanie H Kim Russell R Reid Hue H Luu Rex C Haydon | 2010 | World Journal of Stem Cells2010，2，4： | 35 |
| 2 | Sex-specific effects of Eugenia punicifolia extract on gastric ulcer healing in rats显示文摘AIM To evaluate the sex-specific effects of a hydroalcoholic extract from Eugenia punicifolia(HEEP) leaves on gastric ulcer healing.METHODS In this rat study involving males, intact(cycling) females, and ovariectomized females, gastric ulcers were induced using acetic acid. A vehicle, lansoprazole, or HEEP was administered for 14 d after ulcer induction. Body weight was monitored throughout the treatment period. At the end of treatment, the rats were euthanized and the following in vivo and in vitro investigations were performed: macroscopic examination of the lesion area and organ weights, biochemical analysis, zymography, and evaluation of protein expression levels. Additionally, the concentration-dependent effect of HEEP was evaluated in terms of subacute toxicity and cytotoxicity.RESULTS Compared to the vehicle, HEEP demonstrated a great healing capacity by substantially reducing the ulcerative lesion area in males(52.44%), intact females(85.22%), and ovariectomized females(65.47%), confirming that HEEP accelerates the healing of acetic acidinduced gastric lesions and suggesting that this effect is modulated by female sex hormones. The antiulcer effect of HEEP was mediated by prostaglandin E2 only in male rats. Overall, the beneficial effect of HEEP was the highest in intact females. Notably, HEEP promoted the expression of vascular endothelial growth factor(intact vs ovariectomized females) and decreased the expression of Caspase-8 and Bcl-2(intact female vs male or ovariectomized female). Additionally, HEEP enhanced fibroblast proliferation and migration into a wounded area in vitro, confirming its healing effect. Finally, no sign of subacute toxicity or cytotoxicity of HEEP was observed.CONCLUSION In gastric ulcers, HEEP-induced healing(modulated by female sex hormones; in males, mediated by prostaglandin) involves extracellular matrix remodeling, with gastric mucosa cell proliferation and migration. | Larissa Lucena Périco Vinícius Peixoto Rodrigues Rie Ohara Gabriela Bueno Vania Vasti Alfieri Nunes Raquel Cássia dos Santos Ana Carolina Lima Camargo Luis Antuio Justulin Joior Sérgio Faloni de Andrade Viviane Miranda Bispo Steimbach Luísa Mota da Silva Lúcia Regina Machado da Rocha Wagner Vilegas Catarina dos Santos Clélia Akiko Hiruma-Lima | 2018 | World Journal of Gastroenterology2018，24，38： | 3 |
| 3 | Novel p19 Protein Engages IL-12p40 to Form a Cytokine, IL-23, with Biological Activities Similar as Well as Distinct from IL-12显示文摘 | Birgit Oppmann Robin Lesley Bianca Blom Jackie C Timans Yuming Xu Brisdell Hunte Felix Vega Nancy Yu Jing Wang Komal Singh Francesca Zonin Elena Vaisberg Tatyana Churakova Man-ru Liu Daniel Gorman Janet Wagner Sandra Zurawski Yong-Jun Liu John S Abrams Ke | 2000 | Immunity2000，，5： | 2 |
| 4 | Plasma adiponectin,insulin sensitivity,and subclinical inflammation in women with prior gestational DM显示文摘 | Winzer C Wagner O Fwata A | 2004 | Diabetes Care2004，27，7： | 1 |
| 5 | The psychometric properties of the hospital survey on patient safety culture in Dutch hospitals显示文摘 | Smits M Christiaans-Dingelhoff l Wagner C | 2008 | BMC Health Serv Res2008，8，： | 1 |
| 6 | Hepatic one-carbon metabolism in early folate deficiency in rats显示文摘 | Balaghi M Home D W Wagner C | 1993 | Biochem J1993，291，： | 1 |
| 7 | Electrophoretic, solubility, and functional properties of commercial soy protein isolartes 显示文摘 | Arrese E L Sorgentini D A Wagner J R Anon M C | 1991 | Journal of Agricultural and Food Chemistry1991，39，： | 1 |
| 8 | Liver surgery in the era of tissue-preserving resections:early and late outcome in patients with primary and secondary hepatic tumors显示文摘 | Redaelli C A Wagner M Krahenbuhi L | 2002 | World J Surg2002，26，9： | 1 |
| 9 | Auger and photoelection line energy erlation ships in aluminum-oxygen and Silicon-oxygen compounds显示文摘 | Wagner C D Passoja D E Hillery H F | 1982 | J Vac Sci Technol1982，21，： | 1 |
| 10 | Thermal and electrophoretic behavior,hydrophobicity,and some functional properties of acid-treated soy isolates显示文摘 | Wagner J R Sorgentini D A Anon M C | 1996 | J Agri Food Chem1996，44，： | 1 |
| 11 | Secure routing in wireless sensor networks: attacks and countermeasures 显示文摘 | KARLOF C WAGNER D | 2003 | Elsevier Ad hoc Networks2003，1，1： | 1 |
| 12 | Recurrent laryngeal nerve palsy after thyroid gland surgery显示文摘 | Wagner HE Seller C | 1994 | Br J Surg1994，81，： | 1 |
| 13 | Continuous limit of the Nagel-Schreckenberg model 显示文摘 | Krauss S Wagner P Gawron C | 1996 | Physical Review E1996，54，4： | 1 |
| 14 | Simultaneous analysis of metabolites in potato tuber by gas chromatography-mass spectrome-try显示文摘 | Roessner U Wagner C Tretheway N | | 0，，01： | 1 |
| 15 | The effect of deposition temperature on microstructure and properties of thermal CVD TiN coatings显示文摘 | J Wagner C Mitterer M Penoy | 2008 | Internatlonal Journal of Refractory Metals and Hard Materials2008，26，2： | 1 |
| 16 | Noninvasive brain stimulation may improve stroke-related dysphagia : a pilot study 显示文摘 | Kumar S Wagner CW Frayne C | 2011 | Stroke2011，42，4： | 1 |
| 17 | Hierarchical fuzzy relational models: Linguistic interpretationand Universal approximation显示文摘 | Ricardo J Campello G B Wagner C | 2006 | IEEE Trans on Fuzzy Systems2006，14，3： | 1 |
| 18 | Mini-open tenorrhaphy of acute Achilles tendon ruptures:medium-term follow-up of 100 cases 显示文摘 | Keller A Ortiz C Wagner E | 2014 | Am J Sports Med2014，42，3： | 1 |
| 19 | Theoretical analysis of the diffusion process determining the oxidation rate of alloys显示文摘 | WAGNER C | 1952 | J Electrochem Soc1952，99，2： | 1 |
| 20 | 显示文摘 | | 1961 | Z Elektrochem1961，65，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员