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| 1 | Increased catabolism and decreased unsaturation of ganglioside in patients with inflammatory bowel disease显示文摘AIM: To investigate whether accelerated catabolism of ganglioside and decreased ganglioside content contribute to the etiology of pro-inflammatory intestinal disease. METHODS: Intestinal mucosa from terminal ileum or colon was obtained from patients with ulcerative colitis or inflammatory Crohn's disease(n = 11) undergoing bowel resection and compared to control samples of normal intestine from patients with benign colon polyps(n = 6) and colorectal cancer(n = 12) in this observational case-control study. Gangliosides and phospholipids of intestinal mucosa were characterized by class and ceramide or fatty acid composition using liquid chromatography triple-quad mass spectrometry. Content and composition of ganglioside classes GM1, GM3, GD3, GD1 a, GT1 and GT3 were compared among subject groups. Content and composition of phospholipid classes phosphatidylcholine(PC) and phosphatidylethanolamine were compared among subject groups. Unsaturation index of individual ganglioside and phospholipid classes was computed and compared among subject groups. Ganglioside catabolism enzymes beta-hexosaminidase A(HEXA) and sialidase-3(NEU3) were measured in intestinal mucosa using western blot and compared among subject groups. RESULTS: Relative GM3 ganglioside content was 2-fold higher(P < 0.05) in intestine from patients with inflammatory bowel disease(IBD) compared to control intestine. The quantity of GM3 and ratio of GM3/GD3 was also higher in IBD intestine than control tissue(P < 0.05). Control intestine exhibited 3-fold higher(P < 0.01) relative GD1 a ganglioside content than IBD intestine. GD3 and GD1 a species of ganglioside containing three unsaturated bonds were present in control intestine, but were not detected in IBD intestine. The relative content of PC containing more than two unsaturated bonds was 30% lower in IBD intestine than control intestine(P < 0.05). The relative content of HEXA in IBD intestine was increased 1.7-fold(P < 0.05) and NEU3 was increased 8.3-fold(P < 0.01) compared to normal intestine. Intestinal mucosa in IBD is characterized by increased GM3 content, decreased GD1 a, and a reduction in polyunsaturated fatty acid constituents in GD3, GD1 a and PC.CONCLUSION: This study suggests a new paradigm by proposing that IBD occurs as a consequence of increased metabolism of specific gangliosides. | John J Miklavcic Glen K Shoemaker Vera C Mazurak M Tom Clandinin Tasha DL Hart Kareena L Schnabl Gordon M Lees Bodil MK Larsen Oliver F Bathe Alan BR Thomson M Tom Clandinin | 2015 | World Journal of Gastroenterology2015，21，35： | 3 |
| 2 | Evalution of the airtraq and macintosh laryngoscopes in patients at increased risk for difficult tracheal intubation 显示文摘 | MAHARAJ C H COSTELLO J F HARTE B H | 2008 | Anaesthesia2008，63，2： | 1 |
| 3 | Power flow solutions by Newton's method显示文摘 | Tinney W F Hart C E | | 0，，11： | 1 |
| 4 | A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow显示文摘 | Wynn R F Hart C A Corradi-Perini C | 2004 | Blood2004，104，9： | 1 |
| 5 | Terpinen-4- ol, the main component of the essential oil of Melaleuca alternifolia ( tea tree oil ), suppresses inflammatory media- tor production by activated human monocytes 显示文摘 | HART P H BRAND C CARSON C F | 2000 | Inflam- mation Res2000，49，： | 1 |
| 6 | A BODIPY-Dcdved Fluorescent Probe for Cellular pH Measurements 显示文摘 | Hart F F Xu Y M Jieng D C eta/ | 2013 | Ana/yffca/ Biochemistry2013，435，2： | 1 |
| 7 | Interleukin 9 production in the lungs of infants with severe respiratory syncytial virus bronchiolitis 显示文摘 | MCNAMARA P S FLANAGAN B F HART C A | 2004 | Lancet2004，363，27： | 1 |
| 8 | Orthodontic preparation for orthognathic surgery:how long does it take and why?A retrospective study显示文摘 | Luther F Morris DO Hart C | 2003 | Br J Oral Maxillofac Surg2003，41，6： | 1 |
| 9 | Production of ehemokines in the lungs of infants with severe respiratory syneytial virus bronehiolitis显示文摘 | MCNAMARA P S FLANAGAN B F HART C A | 2005 | J Infect Dis2005，191，8： | 1 |
| 10 | Reaction of aryl grignard reagents with hexahalobenzenes:novel arenes via a multiple aryne sequence 显示文摘 | Harada K Hart H Du C J F | 1985 | J Org Chem1985，50，： | 1 |
| 11 | A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4receptor capable of promoting migration to bone marrow显示文摘 | WYNN R F HART C A CORRADI-PENINI C | 2004 | Blood2004，104，： | 1 |
| 12 | A small proportion of mesenchymal stem cells strongly expresses functionally active CXCR4 receptor capable of promoting migration to bone marrow显示文摘 | WYNN R F HART C A CORRADI-PERINI C | 2004 | Blood2004，104，9： | 1 |
| 13 | Power Flow Solution by Newton's Method显示文摘 | Tinney W F Hart C E | 1967 | IEEE Trans on PAS1967，86，11： | 1 |
| 14 | Visfatin is regulated by rosiglitazone in type 2 diabetes mellitus and influenced by NFKB and JNK in human abdominal subcutaneous adipocytes 显示文摘 | MCGEE K C HARTE A L DA SILVA N F | 2011 | PLoS One2011，6，20： | 1 |
| 15 | Model predictive control of dissolved oxygen concentration based on a self-organizing RBF neural network显示文摘 | Hart H C Qiao J F | 2012 | Control Engineering Practice2012，20，4： | 1 |
| 16 | Ageing Resistance and Corrosion Resistance of Silicone-Epoxy and Polyurethane Top- coats Used in Sea Splash Zone 显示文摘 | Wang Z Y Hart E H Liu F C | 2012 | Material Corrosion2012，63，： | 1 |
| 17 | Orthodontic preparation for orthogna-thic surgery:how long does it take and why A retrospective study显示文摘 | Luther F Morris DO Hart C | | 0，，： | 1 |
| 18 | Power Flow Solution by Newton' s Method显示文摘 | Tinney W F Hart C E | 1967 | IEEE Transactions on Power Apparatus and Systems1967，86，11： | 1 |
| 19 | Evaluation of the Airtraq and Macintosh laryngoscopes in pa- tients at increased risk for difficult tracheal intubation 显示文摘 | Maharaj C H Costello J F Harte B H | 2008 | Anaesthesia2008，63，2： | 1 |
| 20 | Dynamic modeling of product grade transitions for olefin polymerization processes 显示文摘 | Debling J A Hart G C Kuijpers F | 1994 | AIChEJournal1994，40，3： | 1 |
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