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| 1 | Relationship between plasma D(-)-lactate and intestinal damage after severe injuries in rats显示文摘AIM To explore the kinetic changes in plasma D (-)lactate and lipopolysaccharide ( LPS ) levels, and investigate whether D (-)-lactate could be used as a marker of intestinal injury in rats following gut ischemia/reperfusion, burn, and acute necrotizing pancreatitis (ANP).METHODS Three models were developed in rats:gut ischemia/reperfusion obtained by one hour of superior severe burn injury created by 30% of total body surface induced by continuous inverse infusion of sodium taurocholate and trypsin into main pancreatic duct.Plasma levels of D( - )-lactate in systemic circulation and LPS in portal circulation were measured by enzymaticspectrophotometric method and limulus amebocyte lysate (LAL) test kit, respectively. Tissue samples of intestine were taken for histological analysis.RESULTS One hour gut ischemia followed by reperfusion injuries resulted in a significant elevation in plasma D( - )lactate and LPS levels, and there was a significant correlation between the plasma D( - )-lactate and LPS (r =0.719, P<0.05). The plasma concentrations of D(-)lactate and LPS increased significantly at 6 h postburn,and there was also a remarkable correlation between them (r = 0.877, P < 0.01). D ( - )-lactate and LPS levels elevated significantly at 2 h after ANP, with a similar significant correlation between the two levels (r-0.798,P < 0.01 ). The desquamation of intestine villi and infiltration of inflammatory cells in the lamina propria were observed in all groups.CONCLUSION The changes of plasma D( - )-lactate levels in systemic blood paralleled with LPS levels in the portal vein blood. The measurement of plasma D (-)-lactate level may be a useful marker to assess the intestinal injury and to monitor an increase of intestinal permeability and endotoxemia following severe injuries in early stage. | Xiao-Qing Sun Xiao-Bing Fu Rong-Zhan Yi Lü Qun Deng Xiao-Guo Jian Zhi-Yong Sheng Bum Institute, 304~(th)Hospital,Beijing 100037,China Department of General Surgery,Chinese PLA 304 Hospital,Beijing 100037,China | 2001 | World Journal of Gastroenterology2001，7，4： | 56 |
| 2 | 气肿性肾盂肾炎的肾部分切除术与肾保留术的比较显示文摘 | Bum S P Sun-Ju L Youm W K 张鸣(译) 陈朝晖(校) | 2006 | 临床泌尿外科杂志2006，21，10： | 3 |
| 3 | Adolescent resilience: A concept analysis 显示文摘 | Olsson CA Bond L Bums JM | 2003 | Journal of Adolescence2003，26，1： | 1 |
| 4 | Adolescent resilience: a concept analysis 显示文摘 | Olsson C A Bonda L Bums J M | 2003 | Journal of Adolescence2003，，1： | 1 |
| 5 | Measuring the contributions of nitrification and denitrification to the flux of nitrous oxide from soil 显示文摘 | Stevens R J Laughlin R J Bums L C | 1997 | Soil Biology and Biochemistry1997，29，2： | 1 |
| 6 | Controversies in staging of hepatocellular carcinoma 显示文摘 | Justin M Bums Frederick L Greene | 2005 | Hepatobiliary Pancreat Surg2005，12，： | 1 |
| 7 | Seasonality of Kawasaki dis- ease: a global perspective 显示文摘 | Bums JC Herzog L Fabri O | 2013 | Plos One2013，8，74： | 1 |
| 8 | Isolation, puri- fication, and partial characterization of suppression, a novel inhibitor of cell proliferation显示文摘 | LeBoeuf R D Bums J N Bost K L | 1990 | Journal of Biologi- cal Chemistry1990，265，1： | 1 |
| 9 | Salicylate- inducible antibiotic resistance in Pseudomonas cepacia associated with absence of poreforming outer membrane protein 显示文摘 | Bums J L Clark DK | 1992 | Antimicrob Agents Chemother1992，36，10： | 1 |
| 10 | Construction Cycles in the United States since world war Two显示文摘 | GREBLER L BUMS L | 1982 | AKEUEA Journal1982，10，2： | 1 |
| 11 | Characterization andhydrodesulfurization properties of catalysts derived from amorphousmetal-boron materials 显示文摘 | Parks G L Pease M L Bums A W | 2007 | Journal of Catalysis2007，246，2： | 1 |
| 12 | Operationalizing sustainability in regional tourism planning: an application of the limits of acceptable change framework显示文摘 | Bum Y A Bongkoo L Shaferc C S | 2002 | Tourism Management2002，23，： | 1 |
| 13 | Distribution Strategies that Minimize Transportation and Inventory Costs 显示文摘 | BUMS L D HALL R W | 1985 | Operation Research1985，33，3： | 1 |
| 14 | Tollip,a new component of the IL-I RI pathway,links IRAK to the IL-1 receptor显示文摘 | Bums K Clat worthy J Martin L | | 0，，02： | 1 |
| 15 | Soil enzymes in a changing environment: current knowledge and future directions 显示文摘 | Bums R G DeForest J L Marxsen J | 2013 | Soil Biology and Biochemistry2013，58，： | 1 |
| 16 | Virus-like particles associated with banana bunchy top disease contain small single-stranded DNA显示文摘 | Harding R M Bums T M Dale J L | 1991 | J Gen Virol1991，72，： | 1 |
| 17 | Weaning critically ill adults from invasive mechanical ventilation:a national survey 显示文摘 | Karen EA Bums Francois L | 2009 | Can J Anesth/J Can Anesth2009，56，： | 1 |
| 18 | Case study: Automatic reservoir aeration to control manganese in raw water Maryborough town water supply Queensland, Australia 显示文摘 | Bums F L | 1998 | Water Sci Technol1998，37，2： | 1 |
| 19 | Natural compounds as potential treatments of NF2-deficient schwannoma and meningio- ma: cucurbitacin D and goyazensolide 显示文摘 | Spear S A Bums S S Oblinger J L | 2013 | Otol N eurotol2013，34，8： | 1 |
| 20 | Microsatellite variation and population structure in a declining Australian hylid Litoria aurea 显示文摘 | Bums E L Eldridge M D B Houlden B A | 2004 | Mol Ecol2004，13，： | 1 |
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