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| 1 | Heart Disease and Stroke Statistics—2011 Update: A Report From the American Heart Association显示文摘 | Véronique L. Roger Alan S. Go Donald M. Lloyd-Jones Robert J. Adams Jarett D. Berry Todd M. Brown Mercedes R. Carnethon Shifan Dai Giovanni de Simone Earl S. Ford Caroline S. Fox Heather J. Fullerton Cathleen Gillespie Kurt J. Greenlund Susan M. Hailpern | 2011 | Circulation2011，，4： | 4 |
| 2 | Para-aortic lymph node involvement should not be a contraindication to resection of pancreatic ductal adenocarcinoma显示文摘BACKGROUND Para-aortic lymph nodes(PALN)are found in the aortocaval groove and they are staged as metastatic disease if involved by pancreatic ductal adenocarcinoma(PDAC).The data in the literature is conflicting with some studies having associated PALN involvement with poor prognosis,while others not sharing the same results.PALN resection is not included in the standard lymphadenectomy during pancreatic resections as per the International Study Group for Pancreatic Surgery and there is no consensus on the management of these cases.AIM To investigate the prognostic significance of PALN metastases on the oncological outcomes after resection for PDAC.METHODS This is a retrospective cohort study of data retrieved from a prospectively maintained database on consecutive patients undergoing pancreatectomies for PDAC where PALN was sampled between 2011 and 2020.Statistical comparison of the data between PALN+and PALN-subgroups,survival analysis with the Kaplan-Meier method and risk analysis with univariable and multivariable time to event Cox regression analysis were performed,specifically assessing oncological outcomes such as median overall survival(OS)and disease-free survival(DFS).RESULTS 81 cases had PALN sampling and 17(21%)were positive.Pathological N stage was significantly different between PALN+and PALN-patients(P=0.005),while no difference was observed in any of the other characteristics.Preoperative imaging diagnosed PALN positivity in one case.OS and DFS were comparable between PALN+and PALN-patients with lymph node positive disease(OS:13.2 mo vs 18.8 mo,P=0.161;DFS:13 mo vs 16.4 mo,P=0.179).No difference in OS or DFS was identified between PALN positive and negative patients when they received chemotherapy either in the neoadjuvant or in the adjuvant setting(OS:23.4 mo vs 20.6 mo,P=0.192;DFS:23.9 mo vs 20.5 mo,P=0.718).On the contrary,when patients did not receive chemotherapy,PALN disease had substantially shorter OS(5.5 mo vs 14.2 mo;P=0.015)and DFS(4.4 mo vs 9.8 mo;P<0.001).PALN involvement was not identified as an independent predictor for OS after multivariable analysis,while it was for DFS doubling the risk of recurrence.CONCLUSION PALN involvement does not affect OS when patients complete the indicated treatment pathway for PDAC,surgery and chemotherapy,and should not be considered as a contraindication to resection. | Rupaly Pande Shafiq Chughtai Manish Ahuja Rachel Brown David C Bartlett Bobby V Dasari Ravi Marudanayagam Darius Mirza Keith Roberts John Isaac Robert P Sutcliffe Nikolaos A Chatzizacharias | 2022 | World Journal of Gastrointestinal Surgery2022，14，5： | 2 |
| 3 | A comparative chemical and serological study of the full and particles of foot-and-mouth disease virus 显示文摘 | Rowlands D J Sangar D V Brown F | 1975 | J Gen Virol1975，26，： | 2 |
| 4 | Superoxide dismutase and hydrogen peroxide cause rapid nitric oxide breakdown, peroxynitrite production and subsequent cell death 显示文摘 | McBride A G Borutaite V Brown G C | 1999 | Biochim Biophys Acta1999，1454，3： | 1 |
| 5 | Invasive fungal infections:a review of epidemiology and management options 显示文摘 | ENOCH V A LUDLAM H A BROWN N M | 2006 | J Med Microbiol2006，55，7： | 1 |
| 6 | Dietary recommendation to prevent coronary heart disease显示文摘 | BROWN E V | 1990 | Animals of the New York Academy of Science1990，598，： | 1 |
| 7 | The mathematics of Statistical Machine Translation: Parameter Estimation显示文摘 | Brown P F Della Pietra V J Della Pietra S A | 1993 | Compu- tational Linguistics1993，19，2： | 1 |
| 8 | A molecular phylogenetic survey of sea-ice microbial communities (SIMCO)显示文摘 | BROWN M V BOWMAN J P | 2001 | FEMS Microbiology Ecology2001，35，3： | 1 |
| 9 | Deciphering the biology of My cobacterium tuberculosis from the complete genome sequence 显示文摘 | Cole S T Brosch R Parkhill J Gamier T Churcher C Harris D Gordon S V Eiglmeier K Gas S Barry C E Tekaia F Badcock K Basham D Brown D Chillingworth T Cormor R Davies R Devlin K FeltweU T Gentles S Hamlin N Holroyd S Hornsby T Jagels K Kroghs A McLean J Moule S Murphy L Oliver K Osborne J Quail M A Rafandream M A Rogers J Rutter S Seeger K Skelton J Squaraes R Squares S Sulston J E Taylo K Whitehead S Barrell B G | 1998 | Nature1998，393，： | 1 |
| 10 | Subjective and objective outcomes of botulinum toxin type A treatment in vestibulodynia: pilot data 显示文摘 | Brown CS Glazer HI Vogt V | 2006 | J Reprod Med2006，51，： | 1 |
| 11 | Interactions between aboveground and belowground biodi- versity in terrestrial ecosystems: patterns, mechanisms, and feed backs显示文摘 | HOOPER D U BIGNELL D E BROWN V K | 2000 | BioScience2000，50，： | 1 |
| 12 | Detection of muta- tions associated with isoniazid and rifampin resistance in Mycobacteri- um tuberculosis isolates from Samara Region, Russian Federation显示文摘 | Nikolayevsky V Brown T Balabanova Y | 2004 | J Clin Microbiol2004，42，： | 1 |
| 13 | A longitudinal investigation of personal computers in homes : Adoption determinants and emerging challenges 显示文摘 | Venkatesh V Brown S | 2001 | MIS Quarterly2001，25，1： | 1 |
| 14 | Gender-strati- fled analysis of DLG5 R30Q in 4707 patients with Crohn disease and 4973 controls from 12 Caucasian eohorts显示文摘 | Browning BL Annese V Barclay ML | 2008 | J Med Genet2008，45，1： | 1 |
| 15 | Comparative mapping in the Pinaceae显示文摘 | Krutovsky K V Troggio M Brown G R | 2004 | Genetics2004，168，1： | 1 |
| 16 | Post-stroke depression and functional independence : a conundrum 显示文摘 | Brown C Hasson H Thyselius V eta| | 2012 | Acta Neurol Seand2012，126，1： | 1 |
| 17 | Teaching Old Brands New Tricks: Retro Branding and the Revival of Brand Meaning 显示文摘 | BROWN S KOZINETS R V SHERRY J F | 2003 | Journal of Marketing2003，67，7： | 1 |
| 18 | Subjective and objective outcomes of botulinum toxin type A treatment in vestibulodynia:pilot data显示文摘 | Brown CS Glazer HI Vogt V | | 0，，： | 1 |
| 19 | Intravitreal aflibercept(VEGF trap-eye)in wet age-related macular degeneration显示文摘 | Heier JS Brown DM Chong V | 2012 | Ophthalmology2012，119，12： | 1 |
| 20 | Macrophage comple- ment receptors and pathogen clearance 显示文摘 | Campagne M V Wiesmann C Brown E J | 2007 | Cell Microbiol2007，，： | 1 |
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