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| 1 | 健康成人动脉粥样硬化斑块易感性和血栓形成的生物标志物变化与极端空气污染水平相关:北京AIRCHD研究显示文摘空气污染与心血管事件恶化的病理生理机制尚不完全清楚。该文探讨环境空气污染是否可以触发易损斑块.通过全身炎症途径促进血栓形成。方法:在北京AIRCHD研究中.2014-2016年间对73名健康成年人[年龄(23.3±5.4)岁]进行了随访。研究者使用线性混合效应模型评估了空气污染物与动脉粥样硬化斑块易损性、血栓形成和炎症相关生物标志物之间的关系,并使用中介效应分析(mediation analyses)探讨涉及的生物学途径。通过受试者工作特征(receiver operating characteristic,ROC)曲线分析评估每种生物标记物预测环境空气污染暴露的能力。 | 刘青 叶鹏 Xu H Wang T Liu S Brook RD Feng B Zhao Q Song X Yi T Chen J Zhang Y Wang Y Zheng L Rajagopalan S Li J Huang W | 2019 | 中华高血压杂志2019，27，4： | 13 |
| 2 | 内窥镜技术在乙状窦后径路听神经瘤切除术中的应用显示文摘目的 :探讨乙状窦后径路听神经瘤切除术中应用内窥镜的方法及其在减少残瘤发生率中的价值。方法 :常规乙状窦后径路切除听神经瘤 (常规手术组 ) 15例 ,乙状窦后径路加内窥镜检查切除听神经瘤 (结合窥镜组 ) 11例 ,比较其疗效。结果 :常规手术组术后 3例有残留肿瘤 ,而结合窥镜组均为阴性 ;术后听功能、前庭功能障碍发生率及面神经麻痹发生率两组之间差异均无显著性意义。结论 :乙状窦后径路听神经瘤切除术 ,术中使用内窥镜操作方便、安全 ,未出现由此引起的并发症 ,并可防止或减少残留病灶及肿瘤复发的发生率 ,有临床推广应用价值。 | 谭长强 Brookes G B | 2003 | 临床耳鼻咽喉科杂志2003，17，1： | 7 |
| 3 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 4 | 直接评估吗啡刺激糖尿病人隐静脉内皮一氧化氮释放减少显示文摘to directly measure in real time basal and stimulated levels of NO released from human saphenous vein endothelium and to quantify the expression of the μopiate receptor, which has been linked with NO release. METHODS: Saphenous vein segments from patients with type 2 diabetes ( n = 12) and patients without diabetes (n =8) were obtained. The release of NO was measured directly from the endothelium using a NO-specific amperometric probe. NΩ-nitro-L-arginine methyl ester (L-NAME, 0.1 mmol/L), a NO synthase (NOS) inhibitor, or morphine (1 μmol/L), a stimulant, was administered and the measurements were repeated. Values were reported relative to the mean initial measurement of NO release from diabetic endothelium, which was defined as the relative zero level of NO release. A RT-PCR was then performed on the endothelium to measureμ opiate receptor expression. RESULTS: Diabetic patients (n = 12) showed a relative and significantly diminished basal level of released NO, (0.049± 0.012) nmol/L, compared | Thomas V BILHNGER, James A VOSSWINKEL, Patrick CADET, Christos M RIALAS, Harold I MAGAZINE, George B STEFANO(Division of Cardiothoracic Surgery, Department of Surgery, University Hospital and Medical Center, HSC, T19-080, Stony Brook, New York 11794-8191 Neuroscience Research Institute, State University of New York College at Old Westbury, Old Westbury, New York , USA) | 2002 | Acta Pharmacologica Sinica2002，23，2： | 3 |
| 5 | 迟发性膜迷路积水的内耳自身免疫因素研究显示文摘目的 :探讨内耳自身免疫性病理因素在迟发性膜迷路积水 (DEH)发病中的作用。方法 :对 2 6例 (同侧性 1 9例 ,对侧性 7例 )DEH患者行临床观察、听觉功能测试、免疫学试验 ;并施以药物治疗、免疫抑制剂治疗、经迷路 耳蜗神经切断术及迷路后前庭神经切断术治疗 ,再进行疗效分析。结果 :特异性抗体阳性 :同侧性 4例 ,对侧性 1例 ;对侧性 1例特异性细胞免疫反应阳性 ;同侧性 1例循环免疫复合物阳性。 1 1例药物治疗可控制眩晕发作 ,8例经行前庭神经切断术后眩晕消失 ,1例行对侧原发性聋耳鼓室成形术后眩晕消失 ,4例免疫抑制剂治疗有效 ,1例自然缓解 ,1例经药物、免疫治疗及内淋巴囊引流术后无效。结论 :导致先期耳聋的常见病因有突发性聋、脑膜炎、麻疹、乳突手术等 ;DEH与原发性聋的间隔期为 1~ 34年。DEH症状较典型梅尼埃病更难控制。内耳自身免疫性病理因素在本病发病中可能起着重要作用。 | 谭长强 Brookes G B | 2003 | 临床耳鼻咽喉科杂志2003，17，7： | 3 |
| 6 | Endoscopic options for treatment of dysplasia in Barrett's esophagus显示文摘Recent advances in the endoscopic treatment of dysplasia in Barrett's esophagus(BE) have allowed endoscopists to provide effective and durable eradication therapies. This review summarizes the available endoscopic eradication techniques for dysplasia in patients with BE including endoscopic mucosal resection, endoscopic submucosal dissection, photodynamic therapy, argon plasma coagulation, radiofrequency ablation and cryotherapy. | R Brooks Vance Kerry B Dunbar | 2015 | World Journal of Gastrointestinal Endoscopy2015，7，19： | 3 |
| 7 | The growth, utility, and obsolescence of scientific periodical literature 显示文摘 | BROOKES B C | 1970 | Journal of Documentation1970，26，4： | 1 |
| 8 | National beef tenderness survey-1998显示文摘 | Brooks J C Gwartney J B Hale D S | 2000 | J Anim Sci2000，78，： | 1 |
| 9 | The taxonomic value of floral characters in tribe Trigonelleae (Leguminosae),with special reference to Medicago显示文摘 | Small E Crompton C W Brookes B S | 1981 | Canadian Journal of Botany1981，59，9： | 1 |
| 10 | Environmental jolts and industry revolutions: Organizational responses to discontinuous change显示文摘 | Meyer A D Brook G Goes J B | 1990 | Strategic Management Journal1990，11，： | 1 |
| 11 | Measurement of soil microbial biomass provides an early indication of chan- ges in total soil organic matter due to straw in corporation 显示文摘 | Powlson D S Brookes P C Christensen B | 1987 | Soil Biol Bioehem1987，19，： | 1 |
| 12 | Self-guided Langevin dynamics simulation method显示文摘 | Wu X Brooks B R | 2003 | Chem Phys Letter2003，381，： | 1 |
| 13 | Elastin is an essential determinant of arterial morphogenesis显示文摘 | D Y Li B Brooke E C Davis | 1998 | Nature1998，393，21： | 1 |
| 14 | The action of chromium on serum lipids and on atherosclerosis in cholesterol feed rabbits 显示文摘 | Abraham A S Brooks B A Eylath U | 1982 | Atherosclersis1982，42，： | 1 |
| 15 | Photo- synthetic responses to light in seedlings of selected Amazonian and Australian rainforest tree species显示文摘 | LANGENHEIM J H OSMOND C B BROOKS A | 1984 | Oecologia1984，63，： | 1 |
| 16 | Harvesting a crop of gold in plants显示文摘 | Anderson C W N Brooks R R Stewart R B | 1998 | Nature1998，395，6702： | 1 |
| 17 | Wateborne and Sediment Toxicity of Fluxetine to Select Organisms显示文摘 | Brooks B W Turner P K Stanley J K | 2003 | Chemsphere2003，52，6： | 1 |
| 18 | Light hydrocarbons in recent Texas continental shelf and slope sediments显示文摘 | Bernard B B Brook J M Sackett W M | 1978 | Journal of Geophysical Research1978，83，8： | 1 |
| 19 | The derivation and application of the Bradford- ZIPF distribution 显示文摘 | Brookes B C | 1945 | Journal of Documentation1945，24，4： | 1 |
| 20 | Measurement of soil microbial biomass provides an early indication of changes in total soil organic matter due to straw incorporation显示文摘 | Powlson D S Brookes P C Christensen B T | 1987 | Soil Biology and Biochemistry1987，19，： | 1 |
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