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1764篇 您的检索式:作者名="Brien A"
    题名 作者 年代 出处 被引量
1艾滋病的治疗与控制显示文摘感染人类免疫缺陷病毒(HIV)会造成免疫系统致命的进行性的破坏,导致各种被定义为获得性免疫缺陷综合征的机会性感染的发生.HIV感染有CD4表达的细胞,这是主要的病毒受体,见于辅助T淋巴细胞和单核/巨噬细胞.HIV原发感染常引起急性的病毒综合征,表现为发热、皮疹、腹泻和不适,伴有极高水平的血循环病毒水平,在淋巴结、脑和其它储存单位中发生感染.急性期的终结以特异性的HIV免疫应答为标志,包括HIV抗体的出现,对抗体的检测被用于诊断试验.随后的慢性而隐匿的病变期通常没有症状.病毒血症低下但始终存在,在数年的病程中CD4-;T细胞逐渐耗竭.随着病变的加重,CD4-;T细胞会加速丢失,并伴有循环病毒的增多,后者可用血浆HIV RNA检测加以量化(病毒载量).CD4+;T细胞降低至200个/mm3以下时可伴有各种机会性感染的出现.即使没有可确诊为AIDS的疾病出现,CD;T细胞计数低于200个/mm3也可考虑诊断为AIDS.William A O’Brien 2001中国性病艾滋病防治2001,7,1:7
2BRAF and KRAS Mutations in Hyperplastic Polyps and Serrated Adenomas of the Colorectum: Relationship to Histology and CpG Island Methylation Status显示文摘Shi Yang Francis A Farraye Charline Mack Oksana Posnik Michael J O’Brien 2004The American Journal of Surgical Pathology2004,,11:2
3A rapid-response,high-sensitivity nanophase humidity sensor for respiratory monitoring 显示文摘Kalkan A K Li Handong O'Brien C J 2004Electron Device Letters IEEE2004,25,8:1
4SeaWinds validation with research vessels显示文摘BOURASSA M A LEGLER D M O'BRIEN J J 2003J Geophys Res2003,108,2:1
5Neovascular expression of E - selectin, ICAM - 1 and VCAM - 1 in human atherosclerosis and their relation to intimal leukocyte content 显示文摘O'Brien KD McDonald To Chait A 1996Circulation1996,93,4:1
6Using advanced compiler technology to exploit the performance of the cell broadband enginee architecture显示文摘Eichenberger A E O'Brien J K O'Brien K M 2006IBM Systems Journal2006,45,1:1
7Analysis of variation in isolates of Rhizoctonia solani by random amplified polymorohic DNA assay显示文摘Duncan S Barton J E O'brien P A 1993Mycol Res1993,15,:1
8Serum amyloid A:The other inflammatory protein显示文摘O'Brien KD Chait A 2006Curr Atheroscler Rep2006,8,1:1
9Myeloid markers in adult acute lymphoblastic leukemia显示文摘Preti H A Huh Y O Brien O 1995Cancer1995,76,12:1
10Production of antibodies to Staphylococcus aureus serotype 5,8 and 336 using poly(DL-lactide-co-glycoli-de)microspheres显示文摘O′Brien C N Guidry A J attom A F 2000J Dairy Sci2000,83,:1
11Analysis of variation in isolates of Rhizoctonia solani by random amplified polymorphic DNA assay显示文摘Duncan S Barton J E O′Brien P A 1993Mycol Res1993,97,9:1
12Effect of antibodies to staphylococcal alpha and bcta toxins and Stuphylococcus aureus on the cytotoxicity for and adherence of the organism to bovine mammary epithelial cells显示文摘Cifrian E Guidry A J O'Brien C N 1996Am J Vet Res1996,57,9:1
13Can we image beneath salt? 显示文摘O'Brien M J Gray A H 1996The Leading Edge1996,15,1:1
14High efficient phosphorescent emission from organic electroluminescent diodes 显示文摘Baldo M A O'brien D F 1998Nature1998,395,:1
15Plasma C-reactive protein levels among children with sleep-disordered breathing显示文摘Tauman R Ivanenko A O'Brien LM 2004Pediatrics2004,113,6:1
16A human colon cancer cell capable of initiating tumour growth in immunodefieient mice 显示文摘O'Brien CA Pollett A Gallinger S 2007Nature2007,445,7123:1
17Epidemic and Eco- nomic Impacts of Delayed Detection of Foot-and-mouth Disease:a Case Study of a Simulated Outbreak in California显示文摘Carpenter T E O'Brien J M Hagerman A D 2011Journal of Veteri- nary Diagnostic Investigation2011,23,1:1
18Interannual variability in the eastern subtropical North Pacific Ocean显示文摘Leonardi A P Morey S L O'Brien J J 0,,:1
19一般人群中发生心力衰竭的10年风险方程显示文摘目前急需能减轻心力衰竭负担的一级预防策略,但未见实用有效的风险预测工具。该研究旨在得出一个计算心力衰竭事件发生的10年风险方程。研究者根据7个社区队列,至少12年随访的个体水平数据,推导并验证了心力衰竭的种族和性别特异性10年风险方程。1985-2000年间招募年龄30~79岁在基线时无心血管病的研究对象,创建一个集合队列并随机分组以进行方程推导和内部验证。在另两个队列中也评估了该模型的性能。Khan SS Ning H Shah SJ Yancy CW Carnethon M Berry JD Mentz RJ O’Brien E Correa A Suthahar N de Boer RA Wilkins JT Lloyd-Jones DM 刘青 叶鹏 2019中华高血压杂志2019,27,6:1
20Outcome with the hyper-CVAD regimens in lymphoblastic lymphoma显示文摘THOMAS D A O'BRIEN S CORTES J 2004Blood2004,104,:1
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