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| 1 | A gene expression estimator of intramuscular fat percentage for use in both cattle and sheep显示文摘Background:The expression of genes encoding proteins involved in triacyglyceride and fatty acid synthesis and storage in cattle muscle are correlated with intramuscular fat(IMF)%.Are the same genes also correlated with IMF%in sheep muscle,and can the same set of genes be used to estimate IMF%in both species?Results:The correlation between gene expression(microarray) and IMF%in the longissimus muscle(LM) of twenty sheep was calculated.An integrated analysis of this dataset with an equivalent cattle correlation dataset and a cattle differential expression dataset was undertaken.A total of 30 genes were identified to be strongly correlated with IMF%in both cattle and sheep.The overlap of genes was highly significant,8 of the 13 genes in the TAG gene set and 8 of the 13 genes in the FA gene set were in the top 100 and 500 genes respertively most correlated with IMF%in sheep,P-value = 0.Of the 30 genes,CIDEA,THRSP,ACSM1,DGAT2 and FABP4 had the highest average rank in both species.Using the data from two small groups of Brahman cattle(control and Hormone growth promotant-treated[known to decrease IMF%in muscle]) and 22 animals in total,the utility of a direct measure and different estimators of IMF%(ultrasound and gene expression) to differentiate between the two groups were examined.Directly measured IMF%and IMF%estimated from ultrasound scanning could not discriminate between the two groups.However,using gene expression to estimate IMF%discriminated between the two groups.Increasing the number of genes used to estimate IMF%from one to five significantly increased the discrimination power;but increasing the number of genes to 15 resulted in little further improvement.Conclusion:We have demonstrated the utility of a comparative approach to identify robust estimators of IMF%in the LM in cattle and sheep.We have also demonstrated a number of approaches(potentially applicable to much smaller groups of animals than conventional methods) to using gene expression to rank animals for IMF%within a single farm/treatment,or to estimate differences in IMF%between two farms/treatments. | Bing Guo Kritaya Kongsuwan Paul L Greenwood Guanghong Zhou Wangang Zhang Brian P Dalrymple | 2014 | Journal of Animal Science and Biotechnology2014，5，4： | 6 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | The effect ofGibbs adsorption on Marangoni instability in penetration mass transfer显示文摘 | Brian P L T Ross J R | 1972 | AIChE J1972，18，： | 1 |
| 4 | Interfacial turbulence during the absorption of carbon dioxide into monoethanolamine显示文摘 | Brian P L T Vivian J E Matiatos D C | 1967 | AIChE J1967，13，： | 1 |
| 5 | Low-temperature polyol synthesis of AuCuSn2 and AuCuSn2:using solution chemistry to access ternary intermetallic compounds as nanocrystals显示文摘 | Brian M L Nattamai S P B Raymond E S | 2005 | JACS2005，，： | 1 |
| 6 | Leakage Current Monitoring of Composite Long Rod Insulators显示文摘 | BRIAN P COLIN L DON H | 1994 | Properties and Applications of Diejectric Materials1994，，4： | 1 |
| 7 | A review of chromatographic methods for the assessment of phospholipids in biological samples 显示文摘 | Brianna L P Brian S C | 2006 | Biomedical Chromatography2006，20，： | 1 |
| 8 | Does Perceived Organizational Support Mediate the Relationship between Procedural Justice and Behavior? 显示文摘 | Robert H M Gerald L B Brian P N | 1998 | Academy of Organizational Citizenship Management Journal1998，41，3： | 1 |
| 9 | Constraints on the acquisition of remanent magnetization in fine-grained sediments imposed by redeposition experiments显示文摘 | BRIAN C S JEAN P V MAXIME L G | 2006 | Earth and Planetary Science Letters2006，245，： | 1 |
| 10 | Acyl homoserine-lactone quorum-sensing signal generation 显示文摘 | Matthew R P Dale L V Brian L H | 1999 | Prog Natl Acad Sci USA1999，96，： | 1 |
| 11 | On estimating the exponent of power-law frequency distribution显示文摘 | Ethan P W Brian J E Jessica L G | 2008 | Ecology2008，89，4： | 1 |
| 12 | Effect of Gibbs adsorption on Marangoni instabihty显示文摘 | Brian P L T | 1971 | AIChE J1971，17，： | 1 |
| 13 | How to Manage a Urinary Catheter Balloon that Will Not Deflate显示文摘 | Ross P Brian L Jo T | 2006 | Int Urology and Nephrology2006，38，： | 1 |
| 14 | Frost deposition on cold surfaces显示文摘 | Brian P L T Reid R C Shah Y T | 1970 | Industrial Engineering Chemistry Fundamentals1970，9，3： | 1 |
| 15 | Identifying optimal spec- tral bands from in situ measurements of Great Lakes coastal wetlands using second - derivative analysis 显示文摘 | Brian L Becker David P Lusch Jiaguo Qi | 2005 | Remote Sensing of Environment2005，97，2： | 1 |
| 16 | Biological response modifiers in the management of rheumatoid arthritis显示文摘 | Stang L Brian P Hannah Y | 2003 | Am J Health-Systpharm2003，60，15： | 1 |
| 17 | Heterologous protein production using the Pichia pastoris expression system显示文摘 | Sue M P Mariana L F Brian M N | 2005 | Yeast2005，22，： | 1 |
| 18 | Temperature modulation in semiconductor gas sensing显示文摘 | Andrew P L Brian J R | | 0，，： | 1 |
| 19 | Cohort Study of Pioglitazone and Cancer Incidence in Patients With Diabetes显示文摘 | Ferrara Assiamira Lewis James D Quesenberry Charles P Peng Tiffany Strom Brian L Van Den Eeden Stephen K Ehrlich Samantha F Habel Laurel A | 2011 | Diabetes Care2011，，4： | 1 |
| 20 | P las-malevels of IL- Iβ, TNF- α Aand their specificinh ibito rs in undialyzed chronic renal failure, CA PD and hemodialysis patients显示文摘 | Brian JGP Shapiro P L A ndrew J K | 1994 | Kidney Int1994，45，： | 1 |
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