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| 1 | The role of the molecular chaperone heat shock protein A2 (HSPA2) in regulating human sperm-egg recognition显示文摘在人的不孕病人的精子在场的最普通的损害之一是精子鸡蛋识别的自发的失败。尽管这个唯一的细胞的相互作用现在能被象 intracytoplasmic 精子注射(ICSI ) 那样的帮助繁殖策略乐意地绕过,最近的大规模流行病学的研究鼓励了这种技术的小心的使用并且为对为有缺点的精子鸡蛋识别负责的机制的进一步的研究加亮需要。这个领域里的以前的工作证实了为卵母细胞相互作用负责的精子领域在动态地在女繁殖的道在 epididymal 成熟和 capacitation 期间被修改以前在精子发生期间被形成。当为这些顺序的 maturational 事件的规定负责的因素无疑是复杂的时,新兴的研究识别了分子的女伴,加热吃惊蛋白质 A2 (HSPA2 ) ,,在人的精子的这些事件的一个关键管理者。HSPA2 是支持合拢,运输,和集会蛋白质建筑群的 70 kDa 热吃惊蛋白质家庭的一个充实睾丸的成员并且断然被相关与在 vitro 授精(IVF ) 成功。而且,从人的精子 proteome 减少了 HSPA2 的表示为跟随 IVF 和 ICSI 的积云矩阵疏开,精子鸡蛋识别和授精导致一个损害能力。在这评论,我们考虑在精子功能支持 HSPA2 的角色的证据并且探索它被在不肥沃的病人的精子弄空的潜在的机制。进管理精子的分子的机制的如此的信息提议小说卓见工作。 | Brett Nixon Elizabeth G Bromfield Matthew D Dun Kate A Redgrove Eileen A McLaughlin R John Aitken | 2015 | Asian Journal of Andrology2015，17，4： | 8 |
| 2 | Cellular mechanisms regulating sperm-zona pellucida interaction显示文摘 | Andrew T Reid Kate Redgrove R John Aitken Brett Nixon | 2011 | Asian Journal of Andrology2011，13，1： | 6 |
| 3 | Knockout of glutathione peroxidase 5 down-regulates the piRNAs in the caput epididymidis of aged mice显示文摘The mammalian epididymis not only plays a fun dame ntal role in the maturati on of spermatozoa,but also provides protecti on agai nst various stressors.The foremost among these is the threat posed by oxidative stress,which arises from an imbalance in reactive oxygen species and can elicit damage to cellular lipids,proteins,and nucleic acids.In mice,the risk of oxidative damage to spermatozoa is mitigated through the expression and secretion of glutathione peroxidase 5(GPX5)as a major luminal scavenger in the proximal caput epididymidal segment.Accordingly,the loss of GPX5^-/-mediated protection leads to impaired DNA integrity in the spermatozoa of aged Gpx57 mice.To explore the underlying mechanism,we have conducted transcriptomic analysis of caput epididymidal epithelial cells from aged(13 months old)Gpx5^-/-m mice.This analysis revealed the dysregulation of several thousand epididymal mRNA transcripts,in eluding the downregulation of a subgroup of piRNA pathway gen es,in aged Gpx5^-/-mice.In agreeme nt with these fin dings,we also observed the loss of piRNAs,which potentially bind to the P-element-induced wimpy testis(PlWI)-like proteins PIWIL1 and PIWIL2.The absence of these piRNAs was correlated with the elevated mRNA levels of their putative gene targets in the caput epididymidis of Gpx5^-/-mice.Importantly,the oxidative stress response genes tend to have more targeting piRNAs,and many of them were among the top increased genes upon the loss of GPX5^-/-.Taken together,our findings suggest the existence of a previously uncharacterized somatic piRNA pathway in the mammalian epididymis and its possible invoIvement in the aging and oxidative stress-mediated responses. | Chen Chu Lu Yu Joelle Henry-Berger Yan-Fei Ru Ayhan Kocer Alexandre Champroux Zhi-Tong Li Miao He Sheng-Song Xie Wu-Bin Ma Min-Jie Ni Zi-Mei Ni Yun-Li Guo Zhao-Liang Fei Lan-Tao Gou Qiang Liu Samanta Sharma Yu Zhou Mo-Fang Liu Charlie Degui Chen Andrew L Eamens Brett Nixon Yu-Chuan Zhou Joel R Drevet Yong-Lian Zhang | 2020 | Asian Journal of Andrology2020，22，6： | 2 |
| 4 | Use of the extended trochantcric os- teotomy in treating prosthetic hip infection 显示文摘 | Brett R Levine MD Craig J | 2009 | J Arthroplasty2009，24，： | 1 |
| 5 | Effect of temperature and feeding regime on the specific growth rate of sockeye salmon(Oncorhynchus nerka)fry,with a consideration of size effect显示文摘 | Shelbourn J E Brett J R Shirahata S | 1973 | Journal of the Fisheries Research Board of Canada1973，30，8： | 1 |
| 6 | Mediators, moderators and tests for mediation 显示文摘 | James L R Brett J M | 1984 | Journal of Applied Psychology1984，69，2： | 1 |
| 7 | The 'Pulvinar' sign in variant Creutzfeldt-Jakob disease显示文摘 | Molloy S O'Laoide R Brett F | 2000 | Am J Roentgenol2000，175，： | 1 |
| 8 | Temperature tolerance in young Pacific salmon, genus Oncorhynchus显示文摘 | Brett J R | 1952 | J Fish Res Board Can1952，9，6： | 1 |
| 9 | Efficient transformation of scutellar tissue of immature maize embryos显示文摘 | Bretts Chneider R Becker D Lorz H | 1997 | Theor Appl Genet1997，94，： | 1 |
| 10 | A tale of two methods显示文摘 | James L R Mulaik S A Brett J M | 2006 | Organizational Research Methods2006，9，2： | 1 |
| 11 | 10 Environmental factors and growth显示文摘 | BRETT J R | 1979 | Fish Physiology1979，8，： | 1 |
| 12 | A dynamical model of visually-guided steering, obstacle avoidance, and route selection 显示文摘 | FAJEN BRETT R | 2003 | International Journal of Computer Vision2003，54，12： | 1 |
| 13 | Characterisation by EIS of ternary Mg alloys synthesized by mechanical alloying显示文摘 | CHRISTOPHER M A BRETT DIAS L TR1NDADE B FISCHER R M1ES S | 2006 | Electrochimica Acta2006，51，： | 1 |
| 14 | Evolutionary origins of eukaryotic sodium/proton exchangers显示文摘 | BRETT C L DONOWITZ M RAO R | 2005 | American Journal of Physiolo gy-Cell Physiology2005，288，2： | 1 |
| 15 | Environmental factors and growth 显示文摘 | BRETT J R | 1979 | Fish Physiol ogy1979，7，： | 1 |
| 16 | Effect of temperature and feeding regimes on the specific growth rate of sockeyesalmon fry (oncorhynchus nerka)with a consideration of size effect显示文摘 | Shelbourn J E Brett J R Shirahata S | 1973 | Fish Board Can1973，30，： | 1 |
| 17 | Species-dependent effects of zooplankton on planktonic ecosystem processes in castle lake, California显示文摘 | Brett M T Wiackowski K Lubnow F S Mueller-Solger A Eller J J Goldman C R | 1994 | Ecology1994，75，8： | 1 |
| 18 | The respiratory metabolism and swimmingperformance of young sockehe salmon显示文摘 | Brett J R | 1964 | Journal of theFisheries Research Board Canada1964，21，： | 1 |
| 19 | Automatic detection and classification of weld flaws in TOFD data using wavelet transform and support vector machines 显示文摘 | Al-Ataby A Al-Nuaimy W Brett C R | 2010 | Insight: Non-Destructive Testing and Condition Monitoring2010，52，11： | 1 |
| 20 | The respiratory metabolism and swimming performance of young sockeye salmon 显示文摘 | Brett J R | 1964 | Journal of the Fisheries Research Board of Canada1964，21，5： | 1 |
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