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| 1 | Multifunctional to multistage delivery systems: The evolution of nanoparticles for biomedical applications显示文摘Nanomaterials are advancing in several directions with significant progress being achieved with respect to their synthesis, functionalization and biomedical application. In this review, we will describe several classes of prototypical nanocarriers, such as liposomes, silicon particles, and gold nanoshells, in terms of their individual function as well as their synergistic use. Active and passive targeting, photothermal ablation, and drug controlled release constitute some of the crucial functions identified to achieve a medical purpose. Current limitations in targeting, slow clearance, and systemic as well as local toxicity are addressed in reference to the recent studies that attempted to comprehend and solve these issues. The demand for a more sophisticated understanding of the impact of nanomaterials on the body and of their potential immune response underlies this discussion. Combined components are then discussed in the setting of multifunctional nanocarriers, a class of drug delivery systems we envisioned, proposed, and evolved in the last 5 years. In particular, our third generation of nanocarriers, the multistage vectors, usher in the new field of nanomedicine by combining several components onto multifunctional nanocarriers characterized by emerging properties and able to achieve synergistic effects. | MARTINEZ Jonathan O BROWN Brandon S QUATTROCCHI Nicoletta EVANGELOPOULOS Michael FERRARI Mauro TASCIOTTI Ennio | 2012 | Chinese Science Bulletin2012，57，31： | 4 |
| 2 | Th1 cytokines promote T-cell binding to antigen-presenting cells via enhanced hyaluronan production and accumulation at the immune synapse显示文摘Hyaluronan(HA)production by dendritic cells(DCs)is known to promote antigen presentation and to augment T-cell activation and proliferation.We hypothesized that pericellular HA can function as intercellular‘glue’directly mediating T cell–DC binding.Using primary human cells,we observed HA-dependent binding between T cells and DCs,which was abrogated upon pre-treatment of the DCs with 4-methylumbelliferone(4-MU),an agent which blocks HA synthesis.Furthermore,T cells regulate HA production by DCs via T cell-derived cytokines in a T helper(Th)subset-specific manner,as demonstrated by the observation that cell-culture supernatants from Th1 but not Th2 clones promote HA production.Similar effects were seen upon the addition of exogenous Th1 cytokines,IL-2,interferon c(IFN-c)and tumor necrosis factor a(TNF-a).The critical factors which determined the extent of DC–T cell binding in this system were the nature of the pre-treatment the DCs received and their capacity to synthesize HA,as T-cell clones which were pre-treated with monensin,added to block cytokine secretion,bound equivalently irrespective of their Th subset.These data support the existence of a feedforward loop wherein T-cell cytokines influence DC production of HA,which in turn affects the extent of DC–T cell binding.We also document the presence of focal deposits of HA at the immune synapse between T-cells and APC and on dendritic processes thought to be important in antigen presentation.These data point to a pivotal role for HA in DC–T cell interactions at the IS. | Paul L Bollyky Stephen P Evanko Rebecca P Wu Susan Potter-Perigo S Alice Long Brian Kinsella Helena Reijonen Kelly Guebtner Brandon Teng Christina K Chan Kathy R Braun John A Gebe Gerald T Nepom Thomas N Wight | 2010 | Cellular & Molecular Immunology2010，7，3： | 3 |
| 3 | Hydrocompression settlement of deep fills 显示文摘 | Brandon T L Duncan J M Gardner W S | 1990 | ASCE Journal of Geotech Eng1990，116，10： | 1 |
| 4 | A neural networks of carrot tip classification显示文摘 | Brandon J R Howarth M S Searcy S W | 1990 | Trans of the ASAE1990，，： | 1 |
| 5 | Perception of Diesel Engine Gear Rattle Noise显示文摘 | BRANDON S PATRICIA D BOLTON J S | 2015 | SAE2015，，1： | 1 |
| 6 | Osmium recycling in subduction zones显示文摘 | Creaser R A Shirey S B | 1996 | Science1996，272，： | 1 |
| 7 | Properties of bulk polycrystalline CVD diamond显示文摘 | Sussmann R S Brandon J R Scarsbrook G A | 1994 | Diamond and Related Materials1994，，3： | 1 |
| 8 | On steady states in mountain belts 显示文摘 | Willett S D Brandon M T | 2002 | Geology2002，30，2： | 1 |
| 9 | 186Os-187Os systematics of Gorgona Island komatiites:implications for early growth of the inner core显示文摘 | Walker R J Puchtel I S | 2003 | Earth and Planetary Science Letters2003，206，34： | 1 |
| 10 | The effect of root pruning on the maturation of loblolly pine (Pinus taeda) plantlets, rooted hypocotyls, and seedlings显示文摘 | Wisniewski L A Brandon D L McKeand S E | 1991 | Canadian Journal of Forest Research1991，21，7： | 1 |
| 11 | Evaluation of human milk fortification from the time of the first feeding: effects on infants of less than 31 weeks gestational age 显示文摘 | TILLMAN S BRANDON D H SILVA S G | 2012 | J Perinatol2012，32，7： | 1 |
| 12 | In-vitro cytotoxicity of ET-743 (Trebectedin, Yondelis) , a marine anti-cancer drug, in the HepG2 cell line: influence of cytochrome P450 and phase II inhibition, and cytochrome P450 induction 显示文摘 | Brandon E F Meijerman I Klijin J S | 2005 | Anticancer Drugs2005，16，9： | 1 |
| 13 | A history of the theory of prenatal attachment 显示文摘 | Brandon AR Pitts S Denton WH | 2009 | J Prenat Perinat Psychol Health2009，23，4： | 1 |
| 14 | Subpopulation of lymphocytes in the mammary gland of sheep显示文摘 | Lee C S Meeusen E Brandon M R | 1989 | Immunology1989，66，： | 1 |
| 15 | Maternal and fetal repre- sentations, dimensions of personality, and prenatal attachment in women hospitalized with high-risk pregnancy显示文摘 | Brandon AR Pitts S Robinson R | 2007 | J Am Psyehoanal Assoc2007，55，1： | 1 |
| 16 | Physicochemical properties of matte - slag melts taken from vanyukov' s furnace for copper extraction 显示文摘 | Vaisburd S Brandon D G Kozhakhmetov S | 2002 | Metallurgical and Materials Transactions B2002，33，： | 1 |
| 17 | Sequence and regulation of ageneencoding a human89-kilodalton heat shock protein显示文摘 | Hickey E Brandon S E Smale G | 1989 | Molecular and Cellular Biology1989，9，6： | 1 |
| 18 | Osmium recycling in subduction zones显示文摘 | BRANDON A D CREASER R A SHIREY S B | 1996 | Science1996，272，： | 1 |
| 19 | Estimation of tip shape for carrot classification by machine vision显示文摘 | Howarth M S Brandon J R Searcy S W | 1992 | Journal of Agricultural Engineering Research1992，53，： | 1 |
| 20 | Irradiation uniformity of directly driven inertial confinement fusion targets in the context of the shock-ignition scheme显示文摘 | M Temporal R Ramis B Canaud V Brandon S Laffite B J Le Garrec | 2011 | Plasma Physics and Controlled Fusion2011，，12： | 1 |
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