|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Mitochondrial dysfunction and mitochondrial DNA mutations in atherosclerotic complications in diabetes显示文摘Mitochondrial DNA(mtDNA) is particularly prone to oxidation due to the lack of histones and a deficient mismatch repair system.This explains an increased mutation rate of mtDNA that results in heteroplasmy,e.g.,the coexistence of the mutant and wild-type mtDNA molecules within the same mitochondrion.In diabetes mellitus,glycotoxicity,advanced oxidative stress,collagen cross-linking,and accumulation of lipid peroxides in foam macrophage cells and arterial wall cells may significantly decrease the mutation threshold required for mitochondrial dysfunction,which in turn further contributes to the oxidative damage of the diabetic vascular wall,endothelial dysfunc-tion,and atherosclerosis. | Dimitry A Chistiakov Igor A Sobenin Yuri V Bobryshev Alexander N Orekhov | 2012 | World Journal of Cardiology2012，4，5： | 17 |
| 2 | Association of the level of heteroplasmy of the 15059G>A mutation in the MT-CYB mitochondrial gene with essential hypertension显示文摘AIM: To examine whether the heteroplasmy level for 15059G>A mutation in the mitochondrial genome might be associated with essential hypertension. METHODS: This cross-sectional study involved 196 unrelated participants randomly selected from general population (90 males and 106 females) who underwent a regular medical check-up at the Institute for Ath-erosclerosis Research (Moscow, Russia). One hundred and twenty of them (61%) had essential hypertension, and 76 (39%) were apparently healthy normotensive persons. The level of heteroplasmy for 15059G>A mutation occurring in the coding region of cytochrome b gene (MT-CYB) of mtDNA isolated from the blood leukocytes, was quantified using DNA pyrosequencing method. RESULTS: The 15059G>A heteroplasmy level ranged between 4% and 83%, with a median level of 31%. Between the upper and lower quartiles of 15059G>A heteroplasmy distribution, significant differences were observed for patients' age, systolic blood pressure, and triglyceride levels. 15059G>A heteroplasmy correlated both with age (r = 0.331, P < 0.001) and the presence of hypertension (r = 0.228, P = 0.002). Regression analysis revealed that the age explains 12% variability of 15059G>A heteroplasmy, and hypertension independently explains more 5% variability. The 15059G>A heteroplasmy exceeding 31% was found to be significantly associated with a higher risk of essential hypertension (odds ratio 2.76; P (Fisher) 0.019]. The study participants with high 15059G>A heteroplasmy level were found to have significantly higher age (P < 0.001) and the prevalence of essential hypertension (P = 0.033), as compared to those with low 15059G>A heteroplasmy level. These observations suggested a positive correlation between the level of 15059G>A heteroplasmy and essential hypertension. CONCLUSION: This study provides the evidence of association of mtDNA 15059G>A mutation heteroplasmy with essential hypertension. | Igor A Sobenin Dimitry A Chistiakov Margarita A Sazonova Maria M Ivanova Yuri V Bobryshev Alexander N Orekhov Anton Y Postnov | 2013 | World Journal of Cardiology2013，5，5： | 3 |
| 3 | Intimal pericytes as the second line of immune defence in atherosclerosis显示文摘Inflammation plays an essential role in the development of atherosclerosis. The initiation and growth of atherosclerotic plaques is accompanied by recruitment of inflammatory and precursor cells from the bloodstream and their differentiation towards pro-inflammatory phenotypes. This process is orchestrated by the production of a number of pro-inflammatory cytokines and chemokines. Human arterial intima consists of structurally distinct leaflets, with a proteoglycan-rich layer lying immediately below the endothelial lining. Recent studies reveal the important role of stellate pericyte-like cells(intimal pericytes) populating the proteoglycan-rich layer in the development of atherosclerosis. During the pathologic process, intimal pericytes may participate in the recruitment of inflammatory cells by producing signalling molecules and play a role in the antigen presentation. Intimal pericytes are also involved in lipid accumulation and the formation of foam cells. This review focuses on the role of pericytelike cells in the development of atherosclerotic lesions. | Ekaterina A Ivanova Yuri V Bobryshev Alexander N Orekhov | 2015 | World Journal of Cardiology2015，7，10： | 2 |
| 4 | Aortic calcification produced by vitamin D3 plus nicotine显示文摘 | Niederhoffer N Bobryshev YV Lartaud-Idjouadiene I | 1997 | J Vasc Res1997，34，5： | 1 |
| 5 | Monocyte recruitment and foam cell formation in atherosclerosis显示文摘 | Bobryshev YV | 2006 | Micron2006，37，3： | 1 |
| 6 | Expression of heat shock protein-70 by dendritic cells in the arterial intima and its potential significance in atherogenesis显示文摘 | Bobryshev YV Lord RS | 2002 | J Vasc Surg2002，35，2： | 1 |
| 7 | S - 100 positive cells in human arterial intima and in atherosclerotic lesions 显示文摘 | Bobryshev YV Lord RS | 1995 | Cardiovasc Res1995，29，5： | 1 |
| 8 | Dendritic cells in atherosclerosis : current status of the problem and clinical relevance显示文摘 | Bobryshev YV | 2005 | Eur heart J2005，26，17： | 1 |
| 9 | Neovascular expression of VE-cadherin in human atherosclerotic arteries and its relation to intimal inflammation显示文摘 | Bobryshev YV Cherian SM Inder SJ | 1999 | Cardiovasc Res1999，43，： | 1 |
| 10 | S-100 positive cells in human arterial intima and in atherosclerotic lesions 显示文摘 | Bobryshev Y V Lord R S | 1995 | Cardiovasc Res1995，29，5： | 1 |
| 11 | Aortic calcification produced by vitamin D3 plus nicotine 显示文摘 | Niederhoffer N Bobryshev YV Lartaud Idijouadiene I | 1997 | J Vasc Res1997，34，： | 1 |
| 12 | Mapping of vascular dendritic cells in atherosclerotic arteries suggests their involvement in local immune - inflammatory reactions 显示文摘 | Bobryshev YV Lord RS | 1998 | Cardiovasc Res1998，37，3： | 1 |
| 13 | Dendritic cells in the arterial wall expresses Clq: potential significance in atherogenesis 显示文摘 | Cao W Bobryshev YV Lord RS | 2003 | Cardiovasc Res2003，60，1： | 1 |
| 14 | Dendritic cells in atherosclerosis: current status of the problem and clinical relevance显示文摘 | Bobryshev YV | 2005 | Eur HeartJ2005，26，17： | 1 |
| 15 | Mapping of vascular dendritic ceils in atherosclerotic arteries suggests their involvement in local immuneinflammatory reactions 显示文摘 | Bobryshev YV Lord RS | 1998 | Cardiovasc Res1998，37，3： | 1 |
| 16 | Evidence that dendritic cells infiltrate atherosclerotic lesions in apolipoprotein E-deficient mice显示文摘 | Taksir T Lord RS | 2001 | Histol Histopathol2001，16，： | 1 |
| 17 | Dendritic cells in atherosclerosis: current status of the problem and clinical relevance显示文摘 | Bobryshev Y V | 2005 | Eur Heart2005，26，16： | 1 |
| 18 | Mapping of vascular dendritic cells in atherosclerotic arteries suggests their involvement in local immune-inflammatory reactions显示文摘 | Bobryshev YV Reginald S Lord A | 1998 | Cardiovasc Res1998，37，3： | 1 |
| 19 | Dendritic cells and their role in atherogenesis显示文摘 | Bobryshev YV | 2010 | Lab Invest2010，90，7： | 1 |
| 20 | Mapping of vascular dendritic cells in atherosclerotie arteries suggests their involvement in local immuneinflammatory reactions 显示文摘 | Bobryshev Y V Lord R S | 1998 | Cardiovasc Res1998，37，3： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员