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| 1 | Predicting intrinsic disorder in proteins: an overview显示文摘 | Bo He Kejun Wang Yunlong Liu Bin Xue Vladimir N Uversky A Keith Dunker | 2009 | Cell Research2009，19，8： | 11 |
| 2 | Insulin improves cardiac myocytes contractile function recovery in simulated ischemia-reperfusion:Key role of Akt显示文摘The present study examined cardiac myocytecontractile and Ca2+ transient responses to insulin duringsimulated ischemia/reperfusion (I/R) and furtherinvestigated the role of protein kinase B (Akt) in the insulin-induced inotropic effect. Ventricular myocytes wereenzymatically isolated from adult Sprague-Dawley rats and perfused with Tyrode solution while electrically field-stimulated. Simulated I/R was induced by perfusing the cells with chemical anoxic solution including sodiumcyanide-sodium lactate for 15 min followed by reperfusionwith normal oxygenated Tyrode solution with or withoutinsulin. It is found that insulin only at concentration as high as 10 IU/L could increase cell shortening (16±5%, P < 0.05) in normal myocytes, whereas it concentration-dependently (0.01—10 IU/L) increased the contraction,the velocity ofshortening/releng- thening and Ca2+ transient in I/Rmyocytes. In addition, insulin treatment (1 IU/L) increasedAkt phosphorylation of I/R cardiomyocytes by 2.4-foldcompared with that of the control (P < 0.01). Mostimportantly, pretreatment with LY 294002, a specificinhibitor of phosphatidylinositol 3′-kinase (PI3-kinase), significantly inhibited both Akt phosphorylation and thepositive inotropic response to insulin in the I/Rcardiomyocytes. These results suggest that insulin exertsdirect positive inotropic effect by increasing Ca2+ transient of cardiomyocytes, which is enhanced in the pathologicalcondition of I/R. Akt activation plays an important role inthe insulin-induced improvement of myocyte contractile function following I/R. | ZHANG Bo, ZHANG Haifeng, FAN Qian, MA Xinliang & GAO Feng Department of Physiology, The Fourth Military Medical University,Xi抋n 710032, China Correspondence should be addressed to Gao Feng (e-mail: fgao@fmmu.edu.cn) | 2003 | Chinese Science Bulletin2003，48，13： | 9 |
| 3 | Insulin plus incretin:A glucose-lowering strategy for type 2-diabetes显示文摘There are many advantages of combining incretin therapy[glucagon-like peptide-1(GLP-1)receptor agonists and dipeptidyl peptidase-4(DPP-4)inhibitors]with insulin therapy as a glucose-lowering strategy in type2 diabetes.One important advantage is the complementary mode of the mechanistic action of incretin and insulin therapy.Another advantage is the reduction in risk of hypoglycemia and weight gain when adding incretin therapy to insulin.Several clinical trials have studied the addition of GLP-1 receptor agonists[exenatide BID(twice daily),lixisenatide,albiglutide]or DPP-4inhibitors(vildagliptin,sitagliptin,saxagliptin,alogliptin,linagliptin)to ongoing insulin therapy or adding insulin to ongoing therapy with a GLP-1 receptor agonist(liraglutide).These studies show improved glycemia in the presence of limited risk for hypoglycemia and weight gain with the combination of incretin therapy with insulin.This article reviews the background and clinical studies on this combination. | Bo Ahrén | 2014 | World Journal of Diabetes2014，5，1： | 5 |
| 4 | Vildagliptin Enhances Islet Responsiveness to Both Hyper- and Hypoglycemia in Patients with Type 2 Diabetes显示文摘 | Bo Ahrén Anja Schweizer Sylvie Dejager Beth E. Dunning Peter M. Nilsson Margaretha Persson James E. Foley | 2009 | The Journal of Clinical Endocrinology & Metabolism2009，，4： | 3 |
| 5 | The influence of key chemical constituents in activated sludge on surface and flocculating properties显示文摘 | Britt-Marie Wilén Bo Jin Paul Lant | 2002 | Water Research2002，，9： | 3 |
| 6 | Influence of Eutrophication on the Distribution of Total Mercury and Methylmercury in Hydroelectric Reservoirs显示文摘 | Meng Bo Feng X B Chen C X Qiu G L Sommar J Guo Y N Liang P Wan Q | 2010 | EN2010，，5： | 2 |
| 7 | Impacts of morphological, physical and chemical properties of sludge flocs on dewaterability of activated sludge显示文摘 | Bo Jin Britt-Marie Wilén Paul Lant | 2003 | Chemical Engineering Journal2003，，1： | 2 |
| 8 | Inhibition of Dipeptidyl Peptidase-4 Reduces Glycemia, Sustains Insulin Levels, and Reduces Glucagon Levels in Type 2 Diabetes显示文摘 | Bo Ahrén Mona Landin-Olsson Per-Anders Jansson Maria Svensson David Holmes Anja Schweizer | 2004 | The Journal of Clinical Endocrinology & Metabolism2004，，5： | 2 |
| 9 | Sulfuric acid leaching kinetics of South African chromite显示文摘The sulfuric acid leaching kinetics of South African chromite was investigated. The negative influence of a solid product layer constituted of a silicon-rich phase and chromium-rich sulfate was eliminated by crushing the chromite and by selecting proper leaching conditions. The dimensionless change in specific surface area and the conversion rate of the chromite were observed to exhibit a proportional relationship. A modified shrinking particle model was developed to account for the change in reactive surface area, and the model was fitted to experimental data. The resulting model was observed to describe experimental findings very well. Kinetics analysis revealed that the leaching process is controlled by a chemical reaction under the employed experimental conditions and the activation energy of the reaction is 48 kJ ·mol–1. | Qing Zhao Cheng-jun Liu Pei-yang Shi Bo Zhang Mao-fa Jiang Qing-song Zhang Ron Zevenhoven Henrik Saxén | 2015 | International Journal of Minerals,Metallurgy and Materials2015，22，3： | 2 |
| 10 | Physical activity levels and patterns of 9-and 15-yr-old European children显示文摘 | Riddoch CJ Bo Andersen L Wedderkopp N | | 0，，01： | 1 |
| 11 | Expression of inflammationrelated genes in endothelial cells is not directly affected by microparticles from preeclamptic patients显示文摘 | Lok C A Boing A N Reitsma P H | 2006 | J Lab Clin Med2006，147，6： | 1 |
| 12 | Fluid-dynamic boundary layers in CFB boilers 显示文摘 | ZHANG W N JOHNSSON F BO L | 1995 | Chemical Engineering Science1995，50，2： | 1 |
| 13 | Bovine lacto ferrin for Helicobacter pylori eradication: an open, randomized, muhicentre study显示文摘 | DI MARIO F ARAGONA G DAL BO N | 2006 | Aliment Pharmacol Ther2006，23，8： | 1 |
| 14 | Chemical constrituents from pithecellobium cbypearia and their effects on T lymphocytes proliferation 显示文摘 | Guo X Y Wang N L Bo L | 2007 | J Chin Pharmacem Sci2007，16，3： | 1 |
| 15 | High-resolution diatom/clay record in Lake Baikal from grey scale, and magnetic susceptibility over Holocene and Termination I 显示文摘 | Boěs X Piotrowska N Fagel N | 2005 | Global and Planetary Change2005，46，： | 1 |
| 16 | Are Therapeutic Human Mesenchymal Stromal Cells Compatible with Human Blood?显示文摘 | Guido Moll Ida Rasmusson‐Duprez Lena von Bahr Anne‐Marie Connolly‐Andersen Graciela Elgue Lillemor Funke Osama A. Hamad Helena L?nnies Peetra U. Magnusson Javier Sanchez Yuji Teramura Kristina Nilsson‐Ekdahl Olle Ringdén Olle Korsgren Bo Nilsson Katarina | 2012 | STEM CELLS2012，，7： | 1 |
| 17 | Dynamics of magnetic fluid support grinding of Si3N4 ceramic balls for ultraprecision bearings and its importance in spherical surface generation显示文摘 | BO Z AKARI N | 2003 | Precision Engineering2003，，27： | 1 |
| 18 | Analysis of risk factors associatedwith uterine perforation by intrauterine devices显示文摘 | Caliskan E Qzturk N Dilbaz BO | | 0，，03： | 1 |
| 19 | Innovation systems: analytical and methodological issues显示文摘 | Bo Carlsson Staffan Jacobsson Magnus Holmén Annika Rickne | 2002 | Research Policy2002，，2： | 1 |
| 20 | Metal modification by high-power pulsed particle beams显示文摘 | Boǐ ko V I Valyaev A N Pogrebnyak A D | 1999 | Physics-Uspekhi1999，42，11： | 1 |
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