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| 1 | Neuroprotective effects of meloxicam on transient brain ischemia in rats:the two faces of anti-inflammatory treatments显示文摘The inflammato ry response plays an important role in neuroprotection and regeneration after ischemic insult.The use of non-ste roidal anti-inflammatory drugs has been a matter of debate as to whether they have beneficial or detrimental effects.In this context,the effects of the anti-inflammatory agent meloxicam have been scarcely documented after stro ke,but its ability to inhibit both cyclooxygenase isoforms(1 and 2) could be a promising strategy to modulate postischemic inflammation.This study analyzed the effect of meloxicam in a transient focal cerebral ischemia model in rats,measuring its neuroprotective effect after 48 hours and 7 days of reperfusion and the effects of the treatment on the glial scar and regenerative events such as the generation of new progenitors in the subventricular zone and axonal sprouting at the edge of the damaged area.We show that meloxicam’s neuroprotective effects remained after 7 days of reperfusion even if its administration was restricted to the two first days after ischemia.Moreover,meloxicam treatment modulated glial scar reactivity,which matched with an increase in axonal sprouting.However,this treatment decreased the formation of neuronal progenitor cells.This study discusses the dual role of anti-inflammatory treatments after stro ke and encourages the careful analysis of both the neuroprotective and the regenerative effects in preclinical studies. | Irene Fernández Ugidos Paloma González-Rodríguez María Santos-Galdiano Enrique Font-Belmonte Berta Anuncibay-Soto Diego Pérez-Rodríguez JoséManuel Gonzalo-Orden Arsenio Fernández-López | 2023 | Neural Regeneration Research2023，18，9： | 3 |
| 2 | Neuroprotection by salubrinal treatment in global cerebral ischemia显示文摘Most common cerebrovascular accidents(CVAs)result from the occlusion of a blood vessel and are called ischemic stroke.The interruption of the blood flow reduces the oxygen and glucose levels in the neural parenchyma,which in turn decreases the energy of the cells and compromises their homeostasis.This condition has to be reverted for cell survival.One of the homeostatic processes impaired by cerebral ischemia is protein folding in | Berta Anuncibay-Soto María Santos-Galdiano Arsenio Fernández-López | 2016 | Neural Regeneration Research2016，11，11： | 2 |
| 3 | A gene from the human sex-determining region encodes a protein with homology to a conserved DNA binding motif显示文摘 | Sinclair A H Berta P Palmer M S | 1990 | Nature1990，346，： | 1 |
| 4 | Plant root growth, architecture and function显示文摘 | Hodge A Berta G Doussan C Merchan F Crespi M | 2009 | Plant Soil2009，321，12： | 1 |
| 5 | A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif显示文摘 | Sinclair A H Berta P Palmer M S | 1990 | Nature1990，346，： | 1 |
| 6 | Plant root growth, archi- tecture and function 显示文摘 | Hodge A Berta G Doussan C | 2009 | Plant and Soil2009，321，： | 1 |
| 7 | A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif 显示文摘 | Sinclair A H Berta P Palmer M S | 1990 | Nature1990，346，： | 1 |
| 8 | A gene from the human sex-determining region encode a protein with homology to a conserved DNA-binding motif显示文摘 | Sinclair A H Berta P Palmer M S | 1990 | Nature1990，346，： | 1 |
| 9 | On finite solvable groups in which normality is a transitive relation显示文摘 | Bianchi M Gillo Berta Mauri A Herzog M Veradi L | 2000 | J Group Theory2000，，3： | 1 |
| 10 | Morphogenetic modifications induced by the mycorrhizal fungus strain E3 in the root system of Al-lium porrum L显示文摘 | Berta G Fusconi A Trotta A | 1990 | New Phytol1990，114，： | 1 |
| 11 | Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats显示文摘 | Barbara A Rosa T Berta L | 2007 | Psychoneurdendocrinology2007，32，3： | 1 |
| 12 | A gene from the human sex- determining region encodes a protein with homology to a conserved DNA-binding motif 显示文摘 | Sinclair A H Berta P Palmer M S | 1990 | Nature1990，346，： | 1 |
| 13 | A gene from the human sex-determining region encodes a protein with homology to a conserved DNA-binding motif显示文摘 | Sinclair A H Berta P Palmer M S | 1990 | Nature1990，346，6281： | 1 |
| 14 | A gene form the human sex- determining region encodes a protein with homology to a cnsered DNA- binding motif显示文摘 | Sinclair A H Berta P Palmer M S | 1990 | Nature1990，346，： | 1 |
| 15 | A gene from the human sex-deteriming region encodes a protein with homology to a conserved DNA-binding motif显示文摘 | Sinclair A H Berta P Palmer M S | 1990 | Nature1990，346，： | 1 |
| 16 | DGGE and T-RFLP analysis of bacterial succession during mushroo compost production and sequenceaided T RFLP profile of mature compost显示文摘 | Sz6kely A J Sipos R Berta B | 2009 | Microbial Ecology2009，57，3： | 1 |
| 17 | A gene from thehuman sex determining region encodes a protein with ho-mology to a conserved DNA-binding motif 显示文摘 | Sinclair A H Berta P Palmer M S | 1990 | Nature1990，346，： | 1 |
| 18 | Plant root growth, architecture and function显示文摘 | Hodge A Berta G Doussan C | 2009 | Plant Soil2009，321，12： | 1 |
| 19 | A gene from the human sex -determining region encodes a protein with homology to conserved DNA - binding motif显示文摘 | Sinclair A H Berta P Palmer M S | 1990 | Nature1990，346，： | 1 |
| 20 | Expression andpolarized targeting of a rab3 isoform in epithetialcells 显示文摘 | Weber E Berta G Tousson A | 1994 | Journal of Cell Biology1994，125，3： | 1 |
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