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| 1 | PI 3-kinase pathway is responsible for antiapoptotic effects of atrial natriuretic peptide in rat liver transplantation显示文摘AIM:To investigate the in vivo effect of atrial natriureticpeptide(ANP)and its signaling pathway during ortho-topic rat liver transplantation.METHODS:Rats were infused with NaCl,ANP(5 μg/kg),wortmannin(WM,16 μg/kg),or a combination ofboth for 20 min.Livers were stored in UW solution(4°C)for 24 h,transplanted and reperfused.Apoptosis wasexamined by caspase-3 activity and TUNEL staining.Phosphorylation of Akt and Bad was visualized by West-ern blotting and phospho-Akt-localization by confocalmicroscopy.RESULTS:ANP-pretreatment decreased caspase-3activity and TUNEL-positive cells after cold ischemia,indicating antiapoptotic effects of ANP in vivo.The an-tiapoptotic signaling of ANP was most likely caused byphosphorylation of Akt and Bad,since pretreatment withPI 3-kinase inhibitor WM abrogated the ANP-inducedreduction of caspase-3 activity.Interestingly,analysis ofliver tissue by confocal microscopy showed translocationof phosphorylated Akt to the plasma membrane of hepa-tocytes evoked by ANP.CONCLUSION:ANP activates the PI-3-kinase pathwayin the liver in vivo leading to phosphorylation of Bad, an event triggering antiapoptotic signaling cascade inischemic liver. | Uwe Grutzner Melanie Keller Michael Bach Alexandra K Kiemer Herbert Meissner Manfred Bilzer Stefan Zahler Alexander L Gerbes Angelika M Vollmar | 2006 | World Journal of Gastroenterology2006，12，7： | 3 |
| 2 | 带双质量飞轮的动力传动系统各种工况的仿真显示文摘节约实车试验和减少开发周期和成本的一个必不可少的工具是通过各种行驶条件下的仿真来确定双质量飞轮(DMF)的最优参数。另外,仿真还能确定应用于当前设计的新方法的效能。 | Hartmut Bach Wolfgang Kücks Michael Triebel ZF Sachs AG Schweinfurt | 2008 | 传动技术2008，22，3： | 3 |
| 3 | A long‐term nitrogen fertilizer gradient has little effect on soil organic matter in a high‐intensity maize production system显示文摘 | Kimberly H. Brown Elizabeth M. Bach Rhae A. Drijber Kirsten S. Hofmockel Elizabeth S. Jeske John E. Sawyer Michael J. Castellano | 2014 | Glob Change Biol2014，，4： | 2 |
| 4 | Sehsch?rfebestimmung nach Europ?ischer Norm: wissenschaftliche Grundlagen und M?glichkeiten der automatischen Messung显示文摘 | Michael Bach Guntram Kommerell | 1998 | Klin Monatsbl Augenheilkd1998，，04： | 1 |
| 5 | Measuring con- trast sensitivity under different lighting conditions:compari- son of three tests 显示文摘 | Jens Buhren Evdoxia Terzi Michael Bach | 2006 | Optometry and Vision Science2006，83，5： | 1 |
| 6 | Kernel independent component analysis 显示文摘 | Francis Bach Michael Jordan | 2002 | Journal of Machine Leaning Research2002，，3： | 1 |
| 7 | Design, synthe- sis, and preclinical characterization of novel, highly selective in- dole estrogens显示文摘 | CHRIS PM MICHAEL DC BACH DT | 2001 | J Med Chem2001，44，11： | 1 |
| 8 | Kernel independent component analysis显示文摘 | MICHAEL I JORDAN | 2002 | Journal of Machine Learning Research2002，3，： | 1 |
| 9 | The Arthroscopic Management of Partial-Thickness Rotator Cuff Tears: A Systematic Review of the Literature显示文摘 | Eric J. Strauss Michael J. Salata James Kercher Joseph U. Barker Kevin McGill Bernard R. Bach Anthony A. Romeo Nikhil N. Verma | 2011 | Arthroscopy: The Journal of Arthroscopic and Related Surgery2011，，4： | 1 |
| 10 | Kernel independent component analysis显示文摘 | Francis R Bach Michael I Jordan | 2002 | J of Machine Learning Research2002，，3： | 1 |
| 11 | Kernel Independent Component Analysis显示文摘 | Francis R Bach Michael I Jordan | 2002 | Journal of Machine Learning Research2002，，03： | 1 |
| 12 | Looking for a needle in a haystack: Discovery of indigenous Atlantic salmon (Salmo salar L.) in stocked populations显示文摘 | Einar E. Nielsen Michael M. Hansen Lars A. Bach | 2001 | Conservation Genetics2001，，3： | 1 |
| 13 | Long-term organic farming fosters below and aboveground biota: Implications for soil quality, biological control and productivity显示文摘 | Klaus Birkhofer T. Martijn Bezemer Jaap Bloem Michael Bonkowski S?ren Christensen David Dubois Fleming Ekelund Andreas Flie?bach Lucie Gunst Katarina Hedlund Paul M?der Juha Mikola Christophe Robin Heikki Set?l? Fabienne Tatin-Froux Wim H. Van der Putten | 2008 | Soil Biology and Biochemistry2008，，9： | 1 |
| 14 | Noninvasive Arrhythmia Risk Stratification in Idiopathic Dilated Cardiomyopathy: Results of the Marburg Cardiomyopathy Study显示文摘 | Wolfram Grimm Michael Christ Jennifer Bach Hans-Helge Müller Bernhard Maisch | 2003 | Circulation: Journal of the American Heart Association2003，，： | 1 |
| 15 | Kernel Independent Component Analysis显示文摘 | Michael I Jordan | 2002 | Journal of Machine Learning Research2002，，3： | 1 |
| 16 | ISCEV standard for clinical pattern electroretinography (PERG): 2012 update显示文摘 | Michael Bach Mitchell G. Brigell Marko Hawlina Graham E. Holder Mary A. Johnson Daphne L. McCulloch Thomas Meigen Suresh Viswanathan | 2013 | Documenta Ophthalmologica2013，，1： | 1 |
| 17 | Looking for a needle in a haystack: Discovery of indigenous Atlantic salmon ( Salmo salar L.) in stocked populations显示文摘 | Einar E. Nielsen Michael M. Hansen Lars A. Bach | 2001 | Conservation Genetics2001，，3： | 1 |
| 18 | Airway secretionclearance by mechanical exsufflation for post-poliomyelitisventilator-assisted individuals 显示文摘 | Bach JR Smith WH Michaels J | 1993 | Arch Phys Med Rehabil1993，742，： | 1 |
| 19 | TWO-DIMENSIONAL AND DOBUTAMINE STRESS ECHOCARDIOGRAPHY IN THE PREOPERATIVE ASSESSMENT OF PATIENTS WITH END-STAGE LIVER DISEASE PRIOR TO ORTHOTOPIC LIVER TRANSPLANTATION显示文摘 | Carolyn L. Donovan Pamela A. Marcovitz Jeffrey D. Punch David S. Bach Kimberly A. Brown Michael R. Lucey William F. Armstrong | 1996 | Transplantation1996，，8： | 1 |
| 20 | Visual evoked potentials standard 显示文摘 | Odom JV Bach M Barber C Brigell M Michael F Marmor J | 2004 | Doc Ophthalmol2004，108，2： | 1 |
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