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| 1 | Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome显示文摘AIM To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome(ARDS).METHODS Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of i NO(20 ppm) or nebulized epoprostenol(10 μg/mL) was done in all patients. Thereafter, inhaled milrinone(1 mg/mL) alone followed by inhaled milrinone in association with inhaled nitric oxide(iN O) was administered. A jet nebulization device synchronized with the mechanical ventilation was use to administrate the epoprostenol and the milrinone. Hemodynamic measurements and partial pressure of arterial oxygen(PaO_2) were recorded before and after each inhaled therapyadministration.RESULTS The majority of ARDS were of pulmonary cause(n = 13) and pneumonia(n = 7) was the leading underlying initial disease. Other pulmonary causes of ARDS were: Post cardiopulmonary bypass(n = 2), smoke inhalation injury(n = 1), thoracic trauma and pulmonary contusions(n = 2) and aspiration(n = 1). Two patients had an extra pulmonary cause of ARDS: A polytrauma patient and an intra-abdominal abscess Inhaled nitric oxide, epoprostenol, inhaled milrinone and the combination of inhaled milrinone and i NO had no impact on systemic hemodynamics. No significant adverse events related to study medications were observed. The median increase of PaO 2 from baseline was 8.8 mmH g [interquartile range(IQR) = 16.3], 6.0 mm Hg(IQR = 18.4), 6 mm Hg(IQR = 15.8) and 9.2 mm Hg(IQR = 20.2) respectively with i NO, epoprostenol, inhaled milrinone, and i NO added to milrinone. Only i NO and the combination of inhaled milrinone and i NO had a statistically significant effect on PaO 2. CONCLUSION When comparing the effects of inhaled NO, milrinone and epoprostenol, only NO significantly improved oxygenation. Inhaled milrinone appeared safe but failed to improve oxygenation in ARDS. | Martin Albert Daniel Corsilli David R Williamson Marc Brosseau Patrick Bellemare Stéphane Delisle Anne QN Nguyen France Varin | 2017 | World Journal of Critical Care Medicine2017，6，1： | 4 |
| 2 | Pulmonary Rehabilitation for Chronic Obstructive Pulmonary Disease显示文摘 | Y Lacasse L Brosseau S Milne S Martin E Wong GH Guyatt RS Goldstein | 2002 | Physiotherapy2002，，12： | 1 |
| 3 | Hydrogen-gas production with Citrobacter intermedim and Clostridium pasteurianum 显示文摘 | Brosseau J D Zajic J E | 1982 | Journal of Chemical Technology and Biotechnology1982，32，3： | 1 |
| 4 | Efficacy of continuous passive motion following total knee arthroplasty: A meta - analysis显示文摘 | Brosseau L Milne S Wells G | 2004 | J Rheumatol2004，31，11： | 1 |
| 5 | Continuous passive motion following total knee arthroplasty显示文摘 | Milne S Brosseau L Robinson V | 2003 | Cochrane Database Syst Rev2003，，00： | 1 |
| 6 | Construction of context models for word sense disambiguation显示文摘 | Bernard Brosseau Villeneuve Noriko Kando Nie Jianyun | 2011 | Information and Media Technologies2011，6，3： | 1 |
| 7 | The Relationship Between Hydrogen Gas and Butanol Production by Clostridium Saccharoperbutylacetonicum 显示文摘 | Brosseau J D Yan J Y Lo K V | 1986 | Bio- technol Bioeng1986，28，3： | 1 |
| 8 | Microwave characterization of filled polymers显示文摘 | Brosseau C Queffelec P Talbot P | 2001 | Appl Phys2001，89，8： | 1 |
| 9 | Development of a model to predict air contaminant concentration following indoor spills of volatile liquids显示文摘 | Brosseau L M | 1997 | The annals of occupational hygiene1997，41，4： | 1 |
| 10 | Continuous passive motion following total knee at hroplasty显示文摘 | Milne S Brosseau L Robinson V | 2003 | Cochrane Database Syst Rev2003，，2： | 1 |
| 11 | Computational electromagnetics and the rational design of new dielectric heterostructures显示文摘 | BROSSEAU C BEROUAL A | 2003 | Prog Mater Sci2003，48，5： | 1 |
| 12 | Transcutaneous electrical nerve stimulation for the treatment of chronic low back pain: a systematic review 显示文摘 | KJaadilkar A Milne S Brosseau L | 2005 | Spine2005，30，23： | 1 |
| 13 | Massage for low back pain= a systematic review within the framework of the Cochrane Collaboration Back Review Group显示文摘 | Furlan A D Brosseau L Irnamura M | 2002 | Spine2002，27，17： | 1 |
| 14 | 显示文摘 | | 2003 | J Appl Phys2003，，93： | 1 |
| 15 | Molecular me-chanics of mouse cardiac myosin isoforms 显示文摘 | Alpert NR Brosseau C Federico A | 2002 | Am JPhysiol Heart Circ Physiol2002，283，4： | 1 |
| 16 | Tumor microenvironment- associated modifications of alternative splicing 显示文摘 | Brosseau JP Lucier JF Nwilati H | 2014 | RNA2014，20，2： | 1 |
| 17 | The representation of Mongolia in contem- porary travel writing: Imaginative geographies of a travellers' fron- tier显示文摘 | Tavares D Brosseau M | 2006 | Social & Cultural Geography2006，7，2： | 1 |
| 18 | Efficacy of continuous passive motion following total knee arthroplasty:a meta analysis显示文摘 | Brosseau L Milne S Wells G | 2004 | Rheumatol2004，，11： | 1 |
| 19 | Thermotherapy for treatment of osteoarthritis显示文摘 | Brosseau L Yonge KA Robinson V Marchand S Judd M Wells G Tugwell P | | 0，，04： | 1 |
| 20 | Low level laser therapy (Classes Ⅰ , Ⅱ and Ⅲ ) for treating osteoarthritis 显示文摘 | Brosseau L Weleh V Wells G | 2004 | Cochrane Database Syst Rev2004，，00： | 1 |
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