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| 1 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 2 | Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3显示文摘 | Brooks P C Stromblad S Sanders L C | 1996 | Cell1996，85，5： | 4 |
| 3 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 4 | A predictive tool to evaluate disc brake squeal propensity, Part 2: System linearization and modal analysis显示文摘 | LEE Y S BROOKS P C BARTON D C | 2003 | International Journal of Vehicle Design2003，31，： | 1 |
| 5 | Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease显示文摘 | Brooks P Crofford L | 2000 | Arch Intern Med2000，160，： | 1 |
| 6 | Chloroform fu- migation and the release of soil nitrogen: a rapid direct extraction method to measure microbial biomass nitrogen显示文摘 | Brookes P C Landman A G Pruden G | 1987 | Soil Biology and Biochemistry1987，19，6： | 1 |
| 7 | The effect of osteogenic growth factors on bone growth into a ceramic-filled defect around an implant显示文摘 | Clarke S A Brooks R A Lee P T | 2004 | Bone Joint Surg Br2004，22，5： | 1 |
| 8 | Measurement of soil microbial biomass provides an early indication of chan- ges in total soil organic matter due to straw in corporation 显示文摘 | Powlson D S Brookes P C Christensen B | 1987 | Soil Biol Bioehem1987，19，： | 1 |
| 9 | Phosphorus in the soil mi- crobial biomass显示文摘 | Brooks P C Powlson D S Jenkinson D S | 1984 | Soil Biol Biochem1984，16，： | 1 |
| 10 | Ecdysteroids control vitellogenesis and egg maturation in pharate adult females of the Indian meal moth, Plodia interpunctella 显示文摘 | Shirk P D Bean D W Brookes V J | 1990 | Arch Insect Biochem Physiol1990，15，： | 1 |
| 11 | A Double Blind,Randomized,Multicenter,Parallel Group Stydy of the Effectiveness and Tolerance of Intraarticular Hyaluronam in Osteoarthritis of the Knee显示文摘 | DAY d BROOKS P CONAGHAN P G | 2004 | J Rheumatol2004，31，4： | 1 |
| 12 | An extraction method for measuring soil microbial biomass C显示文摘 | Vance E D Brooks P C Jenkinson D S | 1987 | Soil Biology and Biochemistry1987，19，6： | 1 |
| 13 | Growth and growth hormone secretion显示文摘 | Brook C G Hindmarsh P C Stanhope R | 1988 | Endocrinology1988，119，2： | 1 |
| 14 | An extraction method for measuring soil microbial biomass显示文摘 | Vance E D Brookes P C Jenkinson D S | 1987 | Soil Biology & Biochemistry1987，19，： | 1 |
| 15 | Measurement of microbial biomass phosphorus in soil 显示文摘 | BROOKES P C POWLSON D S JENKEINSON D S | 1982 | Soil Biology & Biochemistry1982，14，： | 1 |
| 16 | An extraction meth-od for measuring soil microbial biomass C显示文摘 | Vance E D Brookes P C jenkinson D S | 1987 | Soil Biology^Biochemistry1987，19，6： | 1 |
| 17 | Characterization of porcine plasma ficolins that bind Actinobacillus pleuropneumoniae serotype 5B显示文摘 | BROOKS A S DELAY J P HAYES M A | 2003 | Immunobiology2003，207，： | 1 |
| 18 | An Extraction Method for Measuring Soil Microbial Biomass C 显示文摘 | Vance E D Brookes P C Jenkinson D S | 1987 | Soil Biol- ogy and Biochemistry1987，19，6： | 1 |
| 19 | Wateborne and Sediment Toxicity of Fluxetine to Select Organisms显示文摘 | Brooks B W Turner P K Stanley J K | 2003 | Chemsphere2003，52，6： | 1 |
| 20 | Measurement of soil microbial biomass provides an early indication of changes in total soil organic matter due to straw incorporation显示文摘 | Powlson D S Brookes P C Christensen B T | 1987 | Soil Biology and Biochemistry1987，19，： | 1 |
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