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| 1 | 健康成人动脉粥样硬化斑块易感性和血栓形成的生物标志物变化与极端空气污染水平相关:北京AIRCHD研究显示文摘空气污染与心血管事件恶化的病理生理机制尚不完全清楚。该文探讨环境空气污染是否可以触发易损斑块.通过全身炎症途径促进血栓形成。方法:在北京AIRCHD研究中.2014-2016年间对73名健康成年人[年龄(23.3±5.4)岁]进行了随访。研究者使用线性混合效应模型评估了空气污染物与动脉粥样硬化斑块易损性、血栓形成和炎症相关生物标志物之间的关系,并使用中介效应分析(mediation analyses)探讨涉及的生物学途径。通过受试者工作特征(receiver operating characteristic,ROC)曲线分析评估每种生物标记物预测环境空气污染暴露的能力。 | 刘青 叶鹏 Xu H Wang T Liu S Brook RD Feng B Zhao Q Song X Yi T Chen J Zhang Y Wang Y Zheng L Rajagopalan S Li J Huang W | 2019 | 中华高血压杂志2019，27，4： | 13 |
| 2 | New insights into p53 activation显示文摘肿瘤 suppressor p53 是一多功能,高度调整了,并且对 DNA 特别地敏感的倡导者特定的 transcriptional 因素发信号的损坏和细胞的应力。p53 由指导一个损坏房间的机制击倒小径遗体糟糕理解的房间生长拘捕或 apoptotic。证据建议在里面 p53 的 vivo 功能似乎与发生的损坏的类型和严厉平衡房间命运选择。antirepression 的概念,或通常在海湾保留 p53 的因素的抑制,帮助可以为 p53 激活解释生理的机制。这些因素也在怀有基因的一个野类型的拷贝的肿瘤为 p53 的复活提供新奇化学疗法的目标。 | Christopher L Brooks Wei Gu | 2010 | Cell Research2010，20，6： | 9 |
| 3 | Colonoscopy surveillance for high risk polyps does not always prevent colorectal cancer显示文摘AIM To determine the frequency and risk factors for colorectal cancer(CRC) development among individuals with resected advanced adenoma(AA)/traditional serrated adenoma(TSA)/advanced sessile serrated adenoma(ASSA). METHODS Data was collected from medical records of 14663 subjects found to have AA, TSA, or ASSA at screening or surveillance colonoscopy. Patients with inflammatory bowel disease or known genetic predisposition for CRC were excluded from the study. Factors associated with CRC developing after endoscopic management of high risk polyps were calculated in 4610 such patients who had at least one surveillance colonoscopy within 10 years following the original polypectomy of the incident advanced polyp. RESULTS84/4610(1.8%) patients developed CRC at the polypectomy site within a median of 4.2 years(mean 4.89 years), and 1.2%(54/4610) developed CRC in a region distinct from the AA/TSA/ASSA resection site within a median of 5.1 years(mean 6.67 years). Approximately, 30%(25/84) of patients who developed CRC at the AA/TSA/ASSA site and 27.8%(15/54) of patients who developed CRC at another site had colonoscopy at recommended surveillance intervals. Increasing age; polyp size; male sex; right-sided location; high degree of dysplasia; higher number of polyps resected; and piecemeal removal were associated with an increased risk for CRC developmentat the same site as the index polyp. Increasing age; right-sided location; higher number of polyps resected and sessile endoscopic appearance of the index AA/TSA/ASSA were significantly associated with an increased risk for CRC development at a different site. CONCLUSION Recognition that CRC may develop following AA/TSA/ASSA removal is one step toward improving our practice efficiency and preventing a portion of CRC related morbidity and mortality. | Mohamad A Mouchli Lidia Ouk Marianne R Scheitel Alisha P Chaudhry Donna Felmlee-Devine Diane E Grill Shahrooz Rashtak Panwen Wang Junwen Wang Rajeev Chaudhry Thomas C Smyrk Ann L Oberg Brooke R Druliner Lisa A Boardman | 2018 | World Journal of Gastroenterology2018，24，8： | 5 |
| 4 | Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3显示文摘 | Brooks P C Stromblad S Sanders L C | 1996 | Cell1996，85，5： | 4 |
| 5 | Risk for emerging bipolar disorder, variants, and symptoms in children with attention deficit hyperactivity disorder, now grown up显示文摘AIM: To determine the prevalence of bipolar disorder(BD) and sub-threshold symptoms in children with attention deficit hyperactivity disorder(ADHD) through 14 years' follow-up, when participants were between 21-24 years old.METHODS: First, we examined rates of BD type Ⅰ?and Ⅱ diagnoses in youth participating in the NIMH-funded Multimodal Treatment Study of ADHD(MTA). We used the diagnostic interview schedule for children(DISC), administered to both parents(DISC-P) and youth(DISCY). We compared the MTA study subjects with ADHD(n = 579) to a local normative comparison group(LNCG, n = 289) at 4 different assessment points: 6, 8, 12, and 14 years of follow-ups. To evaluate the bipolar variants, we compared total symptom counts(TSC) of DSM manic and hypomanic symptoms that were generated by DISC in ADHD and LNCG subjects. Then we sub-divided the TSC into pathognomonic manic(PM) and non-specific manic(NSM) symptoms. We compared the PM and NSM in ADHD and LNCG at each assessment point and over time. We also evaluated the irritability as category A2 manic symptom in both groups and over time. Finally, we studied the irritability symptom in correlation with PM and NSM in ADHD and LNCG subjects.RESULTS: DISC-generated BD diagnosis did not differ significantly in rates between ADHD(1.89%) and LNCG 1.38%). Interestingly, no participant met BD diagnosis more than once in the 4 assessment points in 14 years. However, on the symptom level, ADHD subjects reported significantly higher mean TSC scores: ADHD 3.0; LNCG 1.7; P < 0.001. ADHD status was associated with higher mean NSM: ADHD 2.0 vs LNCG 1.1; P < 0.0001. Also, ADHD subjects had higher PM symptoms than LNCG, with PM means over all time points of 1.3 ADHD; 0.9 LNCG; P = 0.0001. Examining both NSM and PM, ADHD status associated with greater NSM than PM. However, Over 14 years, the NSM symptoms declined and changed to PM over time(df 3, 2523; F = 20.1; P < 0.0001). Finally, Irritability(BD DSM criterion-A2) rates were significantly higher in ADHD than LNCG(χ2 = 122.2, P < 0.0001), but irritability was associated more strongly with NSM than PM(df 3, 2538; F = 43.2; P < 0.0001).CONCLUSION: Individuals with ADHD do not appear to be at significantly greater risk for developing BD, but do show higher rates of BD symptoms, especially NSM. The greater linkage of irritability to NSM than to PM suggests caution when making BD diagnoses based on irritability alone as one of 2(A-level) symptoms for BD diagnosis, particularly in view of its frequent presentation with other psychopathologies. | Ahmed Z Elmaadawi Peter S Jensen L Eugene Arnold Brooke SG Molina Lily Hechtman Howard B Abikoff Stephen P Hinshaw Jeffrey H Newcorn Laurence Lee Greenhill James M Swanson Cathryn A Galanter | 2015 | World Journal of Psychiatry2015，5，4： | 3 |
| 6 | Environmental controls on the perology of a late Holocene speleothem from Botswana with annual layers of aragonite and calcite显示文摘 | Railsback L Brook G Chen J | 1994 | Journal of Sedimentary Research1994，64，： | 2 |
| 7 | 英国医学院医学伦理学的教学、学习与评估显示文摘国际伦理快递
[引言]伦理学涵盖内容极其广泛,伦理学不同层次及其内容组成生动的学科树。一般的伦理学概念、基础和基本原则是所有伦理学的基础,是伦理学的主干;不同主题领域的伦理学,如生命伦理学(人类,包括起源)、社会伦理学(社会关系)、医学伦理学(医疗和科技)、职业伦理学(专业领域)等是伦理学对某一领域的深入,构成伦理学的各大分支;各分支领域互有交叉,相互联系,各有侧重。每一分支还可以细化分解,如医学伦理学进一步划分临床医学伦理学、研究医学伦理学等。 | Brooks L Bell D | 2017 | 中国医学伦理学2017，30，3： | 2 |
| 8 | p38 mitogen-actiated protein kinase regulates cycloxxygenase - 2 mRNA stability and transcription in ipopolysacharide-treated human monocytes显示文摘 | Dean J L Brook M Clark A R | 1999 | J Biol Chen1999，274，： | 1 |
| 9 | The D allele of the angiotensin convening enzyme gene contributes towards blood LDL- cholesterol levels and the presence of hypertension显示文摘 | Oren l Brook JG Gershoni-Barueh R | 1999 | Atherosclerosis1999，145，： | 1 |
| 10 | Unresolved issues in the role of cyclooxygenase-2 in normal physiologic processes and disease显示文摘 | Brooks P Crofford L | 2000 | Arch Intern Med2000，160，： | 1 |
| 11 | TLR9 traffics through the Golgi complex to localize to endolysosomes and respond to CpG DNA显示文摘 | CHOCKALINGAM A BROOKS J C CAMERON J L | 2009 | Immunol Cell Biol2009，87，3： | 1 |
| 12 | Effects of day/night temperature differential and irradiance on the flower stem quality of Sandersonia aorantiaca显示文摘 | Davies L J Brooking I R Catley J L | 2002 | Scientia Horticulturae2002，，95： | 1 |
| 13 | Transport of nanoparticles across the rat nasal mucosa显示文摘 | Brooking J Davis SS Illum L | 2001 | J Drug Target2001，9，4： | 1 |
| 14 | Recognizing speech under a processing load:Dissociatting energetic from informational factors显示文摘 | Mattys S L Brooks J Cooke M | | 0，，03： | 1 |
| 15 | Map - Based Cloning of Leaf Rust Resistance Gene Lr21 From the Large and Polyploid Genome of Bread Wheat 显示文摘 | Huang L Brooks S A Li W L | 2003 | Genetics2003，164，： | 1 |
| 16 | Improving research training in doctoral counseling programs 显示文摘 | Galassi J P Stoltz R F Brooks L Trexler K A | 1987 | Journal of Counseling and Development1987，66，9： | 1 |
| 17 | Physiological noise modelling for spinal functional magnetic resonance imaging studies显示文摘 | BROOKS J C BECKMANN C F MILLER K L | 2008 | Neuroimage2008，39，2： | 1 |
| 18 | Localization of matrix metalloproteinase MMP-2 to the surface of invasive cells by interaction with integrin alpha v beta 3显示文摘 | Brooks P C Stromblad S Sanders L C | 1996 | Cell1996，85，5： | 1 |
| 19 | Re- sponses of boreal conifers to climate fluctuations: indications from tree-ring widths and carbon isotope analyses显示文摘 | BROOKS J R FLANAGAN L B EHLERINGER J R | 1998 | Can J For Res1998，28，： | 1 |
| 20 | Cardiac and skeletal muscle adaptations to voluntary wheel running in the mouse显示文摘 | David L Allen Brooke C Harrison | 2001 | J Appl Physiol2001，90，： | 1 |
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