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| 1 | Transarterial chemoembolization using degradable starch microspheres and iodized oil in the treatment of advanced hepatocellular carcinoma: evaluation of tumor response, toxicity, and survival显示文摘BACKGROUND: In a multidisciplinary conference patients with advanced non-resectable hepatocellular carcinoma (HCC) were stratified according to their clinical status and tumor extent to different regional modalities or to best supportive care. The present study evaluated all patients who were stratified to repeated transarterial chemoembolization (TACE) from 1999 until 2003 in terms of tumor response, toxicity, and survival. A moderate embolizing approach was chosen using a combination of degradable starch microspheres (DSM) and iodized oil (Lipiodol) in order to combine anti-tumoral efficiency and low toxicity. METHODS: Fourty-seven patients were followed up prospectively. TACE treatment consisted of cisplatin (50 mg/m2), doxorubicin (50 mg/m2), 450-900 mg DSM, and 5-30 ml Lipiodol. DSM and Lipiodol were administered according to tumor vascularization. Patient characteristics,toxicity, and complications were outlined. In multivariate regression analyses of pre-treatment variables from a prospective database, predictors for tumor response and survival after TACE were determined. RESULTS: 112 TACE courses were performed (2.4±1.5 courses per patient). Mean maximum tumor size was 75 (± 43) mm, in 68% there was bilobar disease. Best response to TACE treatment was: progressive disease (PD) 9%, stable disease (SD) 55%, partial remission (PR) 36%, and complete remission (CR) 0%. Multivariate regression analyses identified tumor size ≤75 mm, tumor number ≤5, and tumor hypervascularization as predictors for PR. The overall 1-, 2-, and 3-year-survival rates were 75%, 59%, and 41%, respectively, and the median survival was 26 months. Low α-fetoprotein levels (<400 ng/ml) (Odds ratio=3.3) and PR as best response to TACE (Odds ratio=6.7) were significantly associated with long term survival (>30 months, R2=36%). Grade 3 toxicity occurred in 7.1% (n=8), and grade 4 toxicity in 3.6% (n=4) of all courses in terms of reversible leukopenia and thrombocytopenia. The incidence of major complications was 5.4% (n=6). All complications were managed conservatively. The mortality within 6 weeks after TACE was 2.1% (one patient). CONCLUSIONS: DSM and Lipiodol were combined successfully in the palliative TACE treatment of advanced HCC resulting in high rates of tumor response and survival at limited toxicity. Favourable tumor response was associated with tumor extent and vascularization. TACE using DSM and Lipiodol can be considered a suitable palliative measure in patients who might not tolerate long acting embolizing agents. | Timm D Kirchhoff Joerg S Bleck Arne Dettmer Ajay Chavan Herbert Rosenthal Sonja Merkesdal Bernd Frericks Lars Zender Nisar P Malek Tim F Greten Stefan Kubicka Michael P Manns Michael Galanski | 2007 | Hepatobiliary & Pancreatic Diseases International2007，6，3： | 15 |
| 2 | Capecitabine and irinotecan with and without bevacizumab for advanced colorectal cancer patients显示文摘AIM:To investigate the efficacy and safety of capecitabine plus irinotecan±bevacizumab in advanced or metastatic colorectal cancer patients. METHODS:Forty six patients with previously untreated,locally-advanced or metastatic colorectal cancer(mCRC) were recruited between 2001-2006 in a prospective open-label phaseⅡtrial,in German community-based outpatient clinics.Patients received a standard capecitabine plus irinotecan(CAPIRI) or CAPIRI plus bevacizumab(CAPIRI-BEV) regimen every 3 wk. Dose reductions were mandatory from the first cycle in cases of>grade 2 toxicity.The treatment choice of bevacizumab was at the discretion of the physician.Theprimary endpoints were response and toxicity and secondary endpoints included progression-free survival and overall survival. RESULTS:In the CAPIRI group vs the CAPRI-Bev group there were more female than male patients(47% vs 24%) ,and more patients had colon as the primary tumor site(58.8%vs 48.2%) with fewer patients having sigmoid colon as primary tumor site(5.9%vs 20.7%) .Grade 3/4 toxicity was higher with CAPIRI than CAPIRI-Bev:82%vs 58.6%.Partial response rates were 29.4%and 34.5%,and tumor control rates were 70.6%and 75.9%,respectively.No complete responses were observed.The median progression-free survival was 11.4 mo and 12.8 mo for CAPIRI and CAPIRI-Bev,respectively.The median overall survival for CAPIRI was 15 mo(458 d) and for CAPIRI-Bev 24 mo(733 d) .These differences were not statistically different.In the CAPIRI-Bev,group,two patients underwent a full secondary tumor resection after treatment,whereas in the CAPIRI group no cases underwent this procedure. CONCLUSION:Both regimens were well tolerated and offered effective tumor growth control in this outpatient setting.Severe gastrointestinal toxicities and thromboembolic events were rare and if observed were never fatal. | Markus Moehler Martin F Sprinzl Murad Abdelfattah Carl C Schimanski Bernd Adami Werner Godderz Klaus Majer Dimitri Flieger Andreas Teufel Juergen Siebler Thomas Hoehler Peter R Galle Stephan Kanzler | 2009 | World Journal of Gastroenterology2009，15，4： | 10 |
| 3 | Noninvasive detection and evaluation of atherosclerotic coronary plaques with multislice computed tomography 1 1 This study was performed without additional financial support.显示文摘 | Stephen Schroeder Andreas F Kopp Andreas Baumbach Christoph Meisner Axel Kuettner Christian Georg Bernd Ohnesorge Christian Herdeg Claus D Claussen Karl R Karsch | 2001 | Journal of the American College of Cardiology2001，，5： | 3 |
| 4 | Digital templating in total hip arthroplasty:Additional anteroposterior hip view increases the accuracy显示文摘AIM To analyze planning total hip arthroplasty(THA) with an additional anteroposterior hip view may increases the accuracy of preoperative planning in THA.METHODS We conducted prospective digital planning in 100 consecutive patients: 50 of these procedures were planned using pelvic overview only(first group), and the other 50 procedures were planned using pelvic overview plus antero-posterior(a.p.) hip view(second group). The planning and the procedure of each patient were performed exclusively by the senior surgeon. Fifty procedures with retrospective analogues planning were used as the control group(group zero). After the procedure, the planning was compared with the eventually implanted components(cup and stem). For statistic analysis the x^2 test was used for nominal variables and the t test was used for a comparison of continuous variables.RESULTS Preoperative planning with an additional a.p. hip view(second group) significantly increased the exact component correlation when compared to pelvic overview only(first group) for both the acetabular cup and the femoral stem(76% cup and 66% stem vs 54% cup and 32% stem). When considering planning ± 1 size, the accuracy in the second group was 96%(48 of 50 patients) for the cup and 94% for the stem(47 of 50patients). In the analogue control group(group zero), an exact correlation was observed in only 1/3 of the cases.CONCLUSION Digital THA planning performed by the operating surgeon and based on additional a.p. hip view significantly increases the correlation between preoperative planning and eventual implant sizes. | Sophia K Stigler Franz J Müller Sebastian Pfaud Michael Zellner Bernd Füchtmeier | 2017 | World Journal of Orthopedics2017，8，1： | 3 |
| 5 | Plasminogen activator inhibitor-1:physiological and pathophysiological roles显示文摘 | Bernd BR Christ G Gruber F | 2002 | News Physiol Sci2002，17，： | 1 |
| 6 | A Thermal Model for High Speed Motorized Spindles显示文摘 | Bernd Bossmanns Jay F Tu | 1999 | International Journal of Machine Tools & Manufacture1999，39，： | 1 |
| 7 | Measuring velocity dispersion and attenuation in the exploration seismic frequency band显示文摘 | Langqiu F S Bernd M Douglas R S | 2009 | Geophysics2009，72，2： | 1 |
| 8 | Detrimental effects of tropisetron on permanent ischemie stroke in the rat 显示文摘 | Eduardo C J Eduardo M Bernd L F | 2008 | BMC Neuroscience2008，9，6： | 1 |
| 9 | The influence of resilience on fatigue in cancer patients undergoing radiation therapy (RT)显示文摘 | Bernhard Strauss Christina Brix Sebastian Fischer Karena Leppert Jürgen Füller Bernd Roehrig Christine Schleussner Thomas G. Wendt | 2007 | Journal of Cancer Research and Clinical Oncology2007，，8： | 1 |
| 10 | An improved Ant System algorithm for the Vehicle Routing Problem 显示文摘 | Richard F Hartl Christine Strauss | 1999 | Annals of Operations Research1999，89，： | 1 |
| 11 | No evidence of increased oxida- tive degradation of urate to allantoin in the CSF and serum of pa- tients with multiple sclerosis显示文摘 | Stefan K Bernd C Bernhard F | 2005 | J Neurol2005，252，5： | 1 |
| 12 | Chemoembolization of oral and oropharyngeal cancer using a highdose cisplatin crystal suspension and degradable starch microspheres 显示文摘 | Adorjdn F Kovdcs Bernd Turowski | 2002 | Oral Oncology2002，，38： | 1 |
| 13 | A thermal model for high speed motorized spindles显示文摘 | JAY F T | 1999 | International Journal of Machine Tools & Manufacture1999，39，： | 1 |
| 14 | A unified approach to fast image registration and a new curvature based registration technique显示文摘 | Bernd F Modersitzki J | 2004 | Linear Algebra and Its Applications2004，380，： | 1 |
| 15 | Calcineurin activityaugments cAMP/PKA-dependent activation of V-ATPasein blowfly salivary glands显示文摘 | Martin V Lennart F Bernd W | 2010 | Am J Physiol Cell Physiol2010，298，： | 1 |
| 16 | Synthesis and Insecticidal Activity of Heterocyclic Substituted Dihydropyrazoles 显示文摘 | RAINER F BERND G CHRISTOPH E et a! | 1997 | Pestic Sci1997，50，： | 1 |
| 17 | A thermal model for high speed motorized spindles显示文摘 | Bernd Bossmanns Jay F Tu | 1999 | International Journal of Machine Tools&Manufacture1999，，39： | 1 |
| 18 | PI3K/AKT pathway alterations are associated with clinically aggressive and histologically anaplastic subsets of pilocytic astrocytoma显示文摘 | Erika F Rodriguez Bernd W | 2010 | Acta Neuropathologica2010，121，3： | 1 |
| 19 | Speed4D technology -shifting paradigms in CT显示文摘 | Thomas F André H Bernd O | 2003 | Siemens Somatom Session2003，3，13： | 1 |
| 20 | Manufacture and properties of molybdenum-rhenium alloys显示文摘 | Bernd F Dietmar F | 2001 | Erzmetall2001，54，： | 1 |
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