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73篇 您的检索式:作者名="BAUMANN R P"
    题名 作者 年代 出处 被引量
1AGNP精神科治疗药物监测共识指南:2011显示文摘治疗药物监测(Therapeutic drug monitoring,TDM),如通过定量测定血清或血浆药物浓度指导用药剂量优化,已经成为对患者进行精神药物治疗的很有价值的工具。在患者用药依从性难以判断、药物耐受性不佳、治疗剂量下无效以及可能存在药代动力学药物-药物相互作用等情况下,测定药物浓度是很有用的。在精神科,有可能明显获益于TDM的主要患者群体包括儿童、孕妇、老年患者、智力障碍患者、涉及司法的患者、已知或怀疑携带药代动力学相关基因变异的患者,以及合并躯体疾病影响药代动力学的患者。然而,只有将TDM充分整合到临床治疗过程中去,才能发挥其优化药物治疗的潜在优势。为了促进TDM的合理应用,神经精神药理学与药物精神病学协会(Arbeitsgemeinschaft für Neuropsychopharmakologie und Pharmakopsychiatrie,AGNP)的TDM专家组在2004年发表了精神药物治疗药物监测指南。之后,随着知识不断更新,又有许多可能需要进行TDM的新药上市。因此,本次更新将神经精神药物的种类扩展到了128种,并将其TDM必要性划分为从'强烈推荐'到'可能有用'的四个等级。经过大量细致且全面的文献检索与分门别类的汇总整理,将基于循证医学理念的'治疗参考浓度范围'和'剂量相关参考浓度范围'呈现给大家。本共识指南引入了'实验室警戒浓度'的新概念,即实验室需要马上告知治疗医生的药物浓度上限。本共识指南还给出了诸如药物作为细胞色素P450酶的底物和抑制剂的性质,代谢物与母药浓度比值的常见范围,以及与结果解释相关的内容,还提供了何时将TDM与遗传药理学检测相结合的建议。遵循本指南,有助于改善许多患者精神药物治疗的效果,特别是那些存在药代动力学异常的患者。TDM是一门交叉学科,有时针对看起来不一致的数据,需要多学科坦诚地讨论,只有这样,患者才能从这种合作中获益。Hiemke C Baumann P Bergemann N Conca A Dietmaier O Egberts K Fric M Gerlach M Greiner C Gründer G Haen E Havemann-Reinecke U Jaquenoud Sirot E Kirchherr H Laux G Lutz UC Messer T Müller MJ Pfuhlmann B Rambeck B Riederer P Schoppek B Stingl J Uhr M Ulrich S Waschgler R Zernig G 李文标(译) 果伟(译) 阮灿军(译) 贺静(译) 汤宜朗(审校) 王传跃(审校) 2016实用药物与临床2016,19,10:37
2Antibiotic Resistance in Salmonella Isolates from Imported Chicken Carcasses in Bhutan and from Pig Carcasses in Vietnam显示文摘Ellerbroek L Narapati D Tai N Phu Poosaran N Pinthong R Sirimalaisuwan A Tshering P Fries R Zessin K-h Baumann M Schroeter A 2010Journal of Food Protection2010,,2:2
3DNA self-recognition in the structure of Potl bound to telomeric single-stranded DNA显示文摘Lei M Podell E R Baumann P 2003Nature2003,426,6963:1
4A novel antisense oligonucleotide targeting surviving expression induces apoptosis and sensitizes lung cancer cells to chemotherapy显示文摘OLIE R A SIMOES-WUST A P BAUMANN B 2000Cancer Res2000,60,11:1
5Effects of prostaglandin E2 on proliferation and apoptosis of epithelial ovarian cancer cells显示文摘Munkarch AR Morris R B Baumann P 2002J Soc Gynecol Inveatlg2002,9,:1
6A novel antisense oligonucleotide targeting Survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy显示文摘Olie R A Simoes-Wust A P Baumann B 2000Cancer Res2000,60,11:1
7Subatance P in hunman essential hypertension显示文摘Fauihaber H D Oehme P Baumann R 1987Cardiovascu Pharmacol1987,10,:1
8Characterization and mapping of equine herpesvirus type 1 immediate early, early, and late transcripts 显示文摘Gray W L Baumann R P Robertson A T 1987Virus Res1987,8,3:1
9Hyaluronan - oligosaccharide - induced transcription of metalloproteases 显示文摘Fieber C Baumann P Vallon R 2004J Cell Sci2004,117,2:1
10Specific features of drug encapsulation in liposomes ( A review) 显示文摘Tanner P Baumann P Enea R 2011Acc Chern Res2011,44,10:1
11Regulation of equine herpesvirus type 1 gene expression: characterization of immediate early, early, and late transcription 显示文摘Gray W L Baumann R P Robertson A T 1987Virology1987,158,1:1
12Potl,the putative telomere end-binding protein in fission yeast and humans显示文摘Baumann P Cech T R 2001Science2001,292,5519:1
13A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy显示文摘Olie R A Simoes-Wust A P Baumann B 2000Cancer Res2000,60,1:1
14Hyaluronan-oligossccharide-induced transcription of metalloproteases显示文摘Fieber C Baumann P Vallon R 2004Cell Sci2004,117,2:1
15Improved high-level expression system for eukaryotie genes in Escherichia coil using T7 RNA polymerase and rare ArgtRNAs 显示文摘Sehenk P M Baumann S Mattes R 1995Biotechniques1995,19,19:1
16Thrombolysis in stroke patients aged 80 years and older: Swiss survey of IV thrombolysis显示文摘S T. Engelter M Reichhart L Sekoranja D Georgiadis A Baumann B Weder F Müller R Lüthy M Arnold P Michel H P. Mattle B Tettenborn H J. Hungerbühler R W. Baumgartner R Sztajzel J Bogousslavsky P A. Lyrer 2005Neurology2005,,11:1
17A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy显示文摘Olie R A Simoes-Wust A P Baumann B 2000Cancer Res2000,60,1:1
18查看详情显示文摘Tanner P Baumann P Enea R Onaca O. Palivan C.and Meier W 0,,:1
19A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy 显示文摘Olie R A Simoes Wust P Baumann B 2007Cancer Res2007,60,11:1
20A novel antisense oligonucleotide targeting survivin expression induces apoptosis and sensitizes lung cancer cells to chemotherapy显示文摘Olie R A Simoes-Wust A P Baumann B 2000Cancer Res2000,60,11:1
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