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| 1 | Methane production and small intestinal bacterial overgrowth in children living in a slum显示文摘AIM:To analyze small intestinal bacterial overgrowth in school-aged children and the relationship between hydrogen and methane production in breath tests.METHODS:This transversal study included 85 children residing in a slum and 43 children from a private school,all aged between 6 and 10 years,in Osasco,Brazil.For characterization of the groups,data regarding the socioeconomic status and basic housing sanitary conditions were collected.Anthropometric data was obtained in children from both groups.All children completed the hydrogen(H 2) and methane(CH 4) breath test in order to assess small intestinal bacterial overgrowth(SIBO).SIBO was diagnosed when there was an increase in H 2 ≥ 20 ppm or CH 4 ≥ 10 ppm with regard to the fasting value until 60 min after lactulose ingestion.RESULTS:Children from the slum group had worse living conditions and lower nutritional indices than children from the private school.SIBO was found in 30.9%(26/84) of the children from the slum group and in 2.4%(1/41) from the private school group(P = 0.0007).Greater hydrogen production in the small intestine was observed in children from the slum group when compared to children from the private school(P = 0.007).A higher concentration of hydrogen in the small intestine(P < 0.001) and in the colon(P < 0.001) was observed among the children from the slum group with SIBO when compared to children from the slum group without SIBO.Methane production was observed in 63.1%(53/84) of the children from the slum group and in 19.5%(8/41) of the children from the private school group(P < 0.0001).Methane production was observed in 38/58(65.5%) of the children without SIBO and in 15/26(57.7%) of the children with SIBO from the slum.Colonic production of hydrogen was lower in methaneproducing children(P = 0.017).CONCLUSION:Children who live in inadequate environmental conditions are at risk of bacterial overgrowth and methane production.Hydrogen is a substrate for methane production in the colon. | Carolina Santos Mello Soraia Tahan Lígia Cristina FL Melli Mirian Silva do Carmo Rodrigues Ricardo Martin Pereira de Mello Isabel Cristina Affonso Scaletsky Mauro Batista de Morais | 2012 | World Journal of Gastroenterology2012，18，41： | 3 |
| 2 | Murine model to study brain,behavior and immunity during hepatic encephalopathy显示文摘AIM:To propose an alternative model of hepatic encephalopathy(HE) in mice,resembling the human features of the disease.METHODS:Mice received two consecutive intraperitoneal injections of thioacetamide(TAA) at low dosage(300 mg/kg).Liver injury was assessed by serum transaminase levels(ALT) and liver histology(hematoxylin and eosin).Neutrophil infiltration was estimated by confocal liver intravital microscopy.Coagulopathy was evaluated using prolonged prothrombin and partial thromboplastin time.Hemodynamic parameters were measured through tail cuff.Ammonia levels were quantified in serum and brain samples.Electroencephalography(EEG) and psychomotor activity score were performed to show brain function.Brain edema was evaluated using magnetic resonance imaging.RESULTS:Mice submitted to the TAA regime developed massive liver injury,as shown by elevation of serum ALT levels and a high degree of liver necrosis.An intense hepatic neutrophil accumulation occurred in response to TAA-induced liver injury.This led to mice mortality and weight loss,which was associated with severe coagulopathy.Furthermore,TAA-treated mice presented with increased serum and cerebral levels of ammonia,in parallel with alterations in EEG spectrum and discrete brain edema,as shown by magnetic resonance imaging.In agreement with this,neuropsychomotor abnormalities ensued 36 h after TAA,fulfilling several HE features observed in humans.In this context of liver injury and neurological dysfunction,we observed lung inflammation and alterations in blood pressure and heart rate that were indicative of multiple organ dysfunction syndrome.CONCLUSION:In summary,we describe a new murine model of hepatic encephalopathy comprising multiple features of the disease in humans,which may provide new insights for treatment. | Lindisley Ferreira Gomides Pedro Elias Marques Bruno Engler Faleiros Rafaela Vaz Pereira Sylvia Stella Amaral Thais Reis Lage Gustavo Henrique Souza Resende Patricia Alves Maia Guidine Giselle Foureaux Fabíola Mara Ribeiro Fabiana Paiva Martins Marco Antonio Peliky Fontes Anderson José Ferreira Remo Castro Russo Mauro Martins Teixeira Márcio Flávio Moraes Antonio Lúcio Teixeira Gustavo Batista Menezes | 2014 | World Journal of Hepatology2014，6，4： | 2 |
| 3 | Flavonoids and mannan oligosaccharides in broiler diets显示文摘 | Batista L S | 2007 | Brazilian Journal of Poultry Science2007，9，1： | 1 |
| 4 | Exploit- ing dynamic reaction cell inductively coupled plasma mass spectrometry (DRC-ICP-MS) for sequential de- termination of trace elements in blood using a dilute- and-shoot procedure显示文摘 | Batista BL Rodrigues JL Nunes JA l | 2009 | Anal Chim Acta2009，639，12： | 1 |
| 5 | Effects of taurine supplementation upon food intake and central insulin signaling in malnourished mice fed on a high-fat diet显示文摘 | Camargo R L Batista T M Ribeiro R A | 2013 | Advances in Experi- mental Medicine and Biology2013，4776，： | 1 |
| 6 | Prediction of liquidliquid equilibrium for systems of vegetable oils, fatty acids, and ethanol显示文摘 | Batista E Monnerat S Stragevitch L | 1999 | J Chem Eng Data1999，44，6： | 1 |
| 7 | Identification of genotype 3 hepatitis E virus (HEV) in serum and fecal samples from pigs in Thailand and Mexico, where genotype 1 and 2 HEV strains are prevalent in the respective human populations 显示文摘 | Cooper K Huang F F Batista L | 2005 | J Clin Microbiol2005，43，4： | 1 |
| 8 | Photocatalyst TiO2-Co: the effect of doping depth profile on methylene blue degradation显示文摘 | CARVALHO H P BATISTA A L BERTHOLDO R | 2010 | Journal of Materials Science2010，45，20： | 1 |
| 9 | Porphyromonas gingivalis infection accelerates the progression of atherosclerosis in a heter- ozygous apolipoprotein E-deficient murine modal显示文摘 | Li L Messas E Batista EL Jr | 2002 | Circula- tion2002，105，7： | 1 |
| 10 | Anti-inflammatory effect of physical training in heartfailure:role of TNF-alpha and IL-10显示文摘 | BATISTA M L Jr LOPES R D SEELAENDER M C | 2010 | Cardiol2010，95，2： | 1 |
| 11 | Chlorella vulgaris biomass used as colouring source in traditional butter cookies显示文摘 | GOUVEIA L BATISTA A P MIRANDA A | 2007 | Innovative Food Science and Emerging Technologies2007，8，3： | 1 |
| 12 | Implantable cardioverter defibrillators and Chagas disease : results of the ICD registry Latin America显示文摘 | MURATORE C A BATISTA SA L A CHIALE P A | 2009 | Europace2009，11，： | 1 |
| 13 | Exploiting dynamic reaction cell inductively coupled plasma mass spectrometry (DRC-ICP-MS) for sequential determination of trace elements in blood using a dilute-and-shoot procedure 显示文摘 | Batista B L Rodrigues J L Nunes J A | 2009 | Analytiea Chimica Acta2009，639，： | 1 |
| 14 | Exploiting dynamic reaction cell inductively coupled plasma mass spectrometry(DRC-CIP-MS)for sequential determination of trace elements in blood using a dilute-andshoot procedure显示文摘 | BATISTA B L RODRIGUES J L NUNES J A | 2009 | Anal Chim Acta2009，639，12： | 1 |
| 15 | Cystic lesion of the ventriculus terminalis: proposal for a new clinical classification 显示文摘 | de Moura Batista L Acioly MA Carvalho CH | 2008 | J Neurosurg Spine2008，8，： | 1 |
| 16 | Gastric antiulcer activity of Syngonanthus arthrotrichus SILVEIRA 显示文摘 | Batista L M de Almeida ABA Magri L D | 2004 | Biol Pharm Bull2004，27，3： | 1 |
| 17 | Identification of genotype 3 hepatitis E virus (HEV) in serum and fecal samples from pigs in Thailand and Mexico, where genotype 1 and 2 HEV strains are prevalent in the respective human populations显示文摘 | Cooper K Huang F F Batista L Rayo C D Bezanilla J C Toth T E Meng X J | 2005 | J Clinic Microbiol2005，43，4： | 1 |
| 18 | Endurance training modulates lymphocyte function in rats with post-MI CHF 显示文摘 | BATISTA M L J R SANTOS R V LOPES R D | 2008 | Med Sci Sports Exerc2008，40，3： | 1 |
| 19 | Isolation and identifica- tion of toxigenic and non-toxigenic fungi in samples of medicinal plants from the market显示文摘 | PEREIRA C G SILVA J R O BATISTA L R | 2015 | Rev Bras Plant Meal2015，17，2： | 1 |
| 20 | Porphyromonas gingivalis Infection Accelerates the Progression of Atheromatotus in a Heterozygous ApolipoproteinE - Deficient Murine Model 显示文摘 | Li L Messas E Batista EL | 2002 | Circulation2002，105，7： | 1 |
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