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| 1 | H pylori (CagA) and Epstein-Barr virus infection in gastric carcinomas:Correlation with p53 mutation and c-Myc,Bcl-2 and Bax expression显示文摘AIM: To investigate the interrelationship between H pylori and Epstein-Barr virus (EBV) infection in the gastric carcinogenesis having in focus the p53 mutation and the c-Myc, Bcl-2 and Bax expression. METHODS: seventy-one gastric carcinoma tissues were assessed by polymerase chain reaction (PCR) for H pylori and in situ hybridization for EBV. c-Myc, Bcl-2 and Bax expression were detected by immunohistochemistry and single-stranded conformational polymorphism (SSCP) for p53 mutation. RESULTS: The positivity rates for H pylori and EBV were 94.4% and 8.45%, respectively. The majority of the cases displayed only the H pylori presence. All EBV positive cases were also H pylori positive. None infectious agent was observed in 5.55% of the cases. The intestinal type tumor was more frequent in the co-infected and non-infected groups. The female predominated in the non-infected group showing statistical significance (70.4% vs 29.6%, P=0.039). The Bcl-2 was only detected in the group exclusively infected by H pylori. However, c-Myc and Bax were detected in the three groups but with a low frequency in the co-infected group. Mutation of p53 was present in all groups, with the highest frequencies in the H pylori positive groups. CONCLUSION: The frequency of H pylori infection in gastric carcinomas was high. The presented data indicated that gastric carcinogenesis has different pathways depending of the presence of the two investigated infectious agents, suggesting a possible involvement of H pylori with apoptotic process. The low expression of c-Myc and Bax in the EBV-positive groups suggests that EBV may inhibit the expression of these proteins. Nevertheless, p53 mutation shows to be a relevant alteration, independent of both infectious agents. | Valeska Portela Lima Marcos Antonio Pereira de Lima Angela Rosa André Márcia Valéria Pitombeira Ferreira Marcos Aurélio Pessoa Barros Sílvia Helena Barem Rabenhorst | 2008 | World Journal of Gastroenterology2008，14，6： | 17 |
| 2 | Photosynthetic performance of two coffee species under drought显示文摘 | Matta F M D Maestri M Barros R S | 1998 | Photosyuthetica1998，，2： | 1 |
| 3 | Do organizational incentives spur innovation?显示文摘 | Barros H M and Lazzarini S G | 2012 | Brazilian Administration Review2012，9，3： | 1 |
| 4 | incidence of postopera- tive residual neuromuscular blockade in the postanaesthesia care unit an observational multicentre study in Portugal 显示文摘 | Esteves S Martins M Barros F | 2013 | Eur J Anaesthesiol2013，30，5： | 1 |
| 5 | Separation of biodiesel and glycerol using ceramic membranes显示文摘 | SERGI GOMES M C PEREIRA N C DAVANTEL DE BARROS S T | 2010 | JournalofMembraneScience2010，352，2： | 1 |
| 6 | Design of a fuzzy controller in mobile robotics using genetic algorithms显示文摘 | M Mucientes D L Moreno S Barro | 2007 | Applied Soft Compu- ting2007，7，2： | 1 |
| 7 | Effects of the vitamin E in catalase activities in hippocampus after status epi- lepticus induced by pilocarpine in wistar rats显示文摘 | Barros D O Xavier S M L Barbosa C O etal | 2007 | Neuroscencei Letters2007，416，3： | 1 |
| 8 | Pulmonary involvement in ankylosing spondylitis显示文摘 | SAMPAIO - BARROS P D CERQUEIRA E M REZENDE S M | 2007 | Clin Rheumatol2007，26，2： | 1 |
| 9 | Antioxidant activity of the microalga Spirulina maxima显示文摘 | Miranda M S Cintra R G Barros S B M | 1998 | Braz J Med Biol Res1998，31，8： | 1 |
| 10 | Asymmetric mating interactions drive widespread invasion and displacement in a whitefly显示文摘 | Liu S S De Barro P J Xu J Luan J B Zang L S Ruan Y M Wan F H | | 0，，： | 1 |
| 11 | Preliminary phylogeny of Encarsia Forster ( Hymenoptera: Aphelinidae) based on morphology and 28s rDNA 显示文摘 | BABCOCK C S HEARTY J M DE BARRO P J | 2001 | Mol Phylogen Evol2001，18，2： | 1 |
| 12 | Review on pre- and post-harvest management of peanuts to minimize aflatoxin contamination显示文摘 | Torres A M Barros G G Palacios S A Chulze S N Battilani P | 2014 | Food Research International2014，62，8： | 1 |
| 13 | Classifying multichannel ECG patterns with an adaptive neural network显示文摘 | Barro S Fernandez-Delgado M Vila-Sobrino JA | 1998 | Engineering in Medicine and Biology Magazine1998，17，1： | 1 |
| 14 | Strawberry-tree, blackthorn and rose fruits: Detailed characterization, in nutrients and phytochemicals with antioxidant properties显示文摘 | BARROS L CARVALHO A M MORAIS J S | 2010 | Food Chemistry2010，120，1： | 1 |
| 15 | Dihydrochalcones and flavonollgnans from Iryanthera lancifolia显示文摘 | D H S Silva S C Davion S B M Barros | 1999 | J Natural Prod1999，62，11： | 1 |
| 16 | Results of surgical treatment com- pared with ultrasound-guided foam sclerotherapy in patients with varicose veins:a prospective randomised study显示文摘 | Figueiredo M Araujo S Barros N | 2009 | Eur J Vasc Endovasc Surg2009，38，6： | 1 |
| 17 | Targeted metabolites analysis in wild Boletus species显示文摘 | Heleno S A Barros L Sousa M J | 2011 | LWT-Food Science and Technology2011，44，6： | 1 |
| 18 | Patterns of Wildlife Value Orientations in Hunters' Families显示文摘 | Zinn H C Manfredo M J Barro S C | 2002 | Human Dimensions of Wildlife2002，7，3： | 1 |
| 19 | Bemisia tabaci:a statement of species status显示文摘 | De Barro P Liu S S Boykin L M | 2011 | Annual Review of Entomol- ogy2011，56，： | 1 |
| 20 | Calculation of the specific rate of catabolic activity (Ac) from the heat flow rate of soil microbial reactions measured by calorimetry: significance and applications 显示文摘 | Barros N Gallego M Feijóo S | 2004 | Chem Biodivers2004，1，： | 1 |
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