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| 1 | Macrophage migration inhibitory factor gene polymorphisms in inflammatory bowel disease: An association study in New Zealand Caucasians and meta-analysis显示文摘AIM:To investigate the association of macrophage migration inhibitory factor(MIF)promoter polymorphisms with inflammatory bowel disease(IBD)risk.METHODS:One thousand and six New Zealand Caucasian cases and 540 Caucasian controls were genotyped for the MIF SNP-173G>C(rs755622)and the repeat polymorphism CATT5-8(rs5844572)using a predesigned TaqMan SNP assay and capillary electrophoresis,respectively.Data were analysed for single site and haplotype association with IBD risk and phenotype.Meta-analysis was employed,to assess cumulative evidence of association of MIF-173G>C with IBD.All published genotype data for MIF-173G>C in IBD were identified using PubMed and subsequently searching the references of all PubMed-identified studies.Imputed genotypes for MIF-173G>C were generated from the Wellcome Trust Case Control Consortium(and National Institute of Diabetes and Digestive and Kidney Diseases).Separate meta-analyses were performed on Caucasian Crohn’s disease(CD)(3863 patients,6031controls),Caucasian ulcerative colitis(UC)(1260 patients,1987 controls),and East Asian UC(416 patients and 789 controls)datasets using the Mantel-Haenszel method.The New Zealand dataset had 93%power,and the meta-analyses had 100%power to detect an effect size of OR=1.40 atα=0.05,respectively.RESULTS:In our New Zealand dataset,single-site analysis found no evidence of association of MIF polymorphisms with overall risk of CD,UC,and IBD or disease phenotype(all P values>0.05).Haplotype analysis found the CATT5/-173C haplotype occurred at a higher frequency in New Zealand controls compared to IBD patients(0.6 vs 0.01;P=0.03,OR=0.22;95%CI:0.05-0.99),but this association did not survive bonferroni correction.Meta-analysis of our New Zealand MIF-173G>C data with data from seven additional Caucasian datasets using a random effects model found no association of MIF polymorphisms with CD,UC,or overall IBD.Similarly,meta-analysis of all published MIF-173G>C data from East Asian datasets(416UC patients,789 controls)found no association of this promoter polymorphism with UC. | James D Falvey Robert W Bentley Tony R Merriman Mark B Hampton Murray L Barclay Richard B Gearry Rebecca L Roberts | 2013 | World Journal of Gastroenterology2013，19，39： | 9 |
| 2 | Tumor necrosis factor induction by an aqueous phenol-extracted lipopolysac-charide complex from Bacteroides species 显示文摘 | Delahooke D M Barclay G R Poxton 1 R | 1995 | Infect Immun1995，63，3： | 1 |
| 3 | Interdepartmental Conflict in Organizational Buying:The Impact of the Organizational Context显示文摘 | Barclay D W | 1991 | Journal of Marketing Research1991，28，5： | 1 |
| 4 | The Partial Least Squares (PLS) Approach to Causal Modeling: Personal Computer Adoption and Useasan Illustration 显示文摘 | Barclay D Higgim C Thompson R | 1995 | Technology Studies1995，2，2： | 1 |
| 5 | Phenotypic charac terization of regulatory CD4^+ CD25^- T cells in rats显示文摘 | Stephens LA Barclay AN Mason D | 2004 | Int Immunol2004，16，2： | 1 |
| 6 | Effect of age, Breast density, and family history on the sensitivity of first screening mammography显示文摘 | Kerliknwske K Grady D Barclay J | 1996 | JAMA1996，276，1： | 1 |
| 7 | Regulation of exocytosis by protein kinase C显示文摘 | MORGAN A BURGOYNE R D BARCLAY J W | 2005 | Biochem Soc Trans2005，33，6： | 1 |
| 8 | Phenotyp ic characteriza- tion of regulatory CD446+ CD25^+ T cells in rats 显示文摘 | Stephens LA Barclay AN Mason D | 2004 | Int Imm- unol2004，16，2： | 1 |
| 9 | Private Placements and Managerial Entrenchment 显示文摘 | BARCLAY M J HOLDERNESS C G SHEEHAN D P | 2007 | Journal of Corporate Finance2007，13，9： | 1 |
| 10 | The Effects of Organizational Differences and Trust on the Effectiveness of Selling Partner Relationships 显示文摘 | Smith J B D W Barclay | 1997 | Journal of Marketing1997，61，1： | 1 |
| 11 | When explanation for layoffs are not enough:Employer's integrity as a moderator of the relationship between informational justice and retaliation显示文摘 | Skarlicki D P Barclay L J Pugh D | 2008 | Journal of Occupational and Organizational Psychology2008，81，1： | 1 |
| 12 | Effect of age, breast density, and family history on the sensitivity of first screening mammography 显示文摘 | KerlikoWske K Grady D Barclay J | 1996 | JAMA1996，276，1： | 1 |
| 13 | Gastricemptying in healthy newborns fed an intact protein formula, apartially and an extensively hydrolysed formula 显示文摘 | Staelens S Van den Driessche M Barclay D | 2008 | Clin Nutr2008，27，2： | 1 |
| 14 | Some aspects of anion-induced adsorption of white metal cations on mercury显示文摘 | Barclay D J Anson F C | 1970 | J Electroanal Chem1970，28，： | 1 |
| 15 | A model for a single species with two life history stages and added mortality显示文摘 | Barclay H J Driessche P V D | 1980 | Ecol Model1980，11，： | 1 |
| 16 | Private placements and managerial entrenchment显示文摘 | Barclay M J Holderness C G Sheehan D P | 2007 | Journal of Corporate Finance2007，13，： | 1 |
| 17 | Peroxidation reactions in plant membranes:effects of free fatty acids显示文摘 | K D Barclay B D McKersie | | 0，，： | 1 |
| 18 | Wavefront expansion for nonlinear axial shear wave propagation 显示文摘 | BARCLAY D W | 1998 | International Journal of Non-linear Mechanics1998，33，2： | 1 |
| 19 | Phenotypic characterization of regulatory CD4+CD25+ T cells in rats显示文摘 | Stephens LA Barclay AN Mason D | 2004 | Int Immunol2004，16，2： | 1 |
| 20 | Shock front analysis for axial shear wave propagation in a hyperelastic incompressible solid 显示文摘 | BARCLAY D W | 1999 | International Journal of Non-linear Mechanics1999，133，14： | 1 |
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