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| 1 | Blood glucose changes surrounding initiation of tumor-necrosis factor inhibitors and conventional disease-modifying anti-rheumatic drugs in veterans with rheumatoid arthritis显示文摘AIM To determine the scope of acute hypoglycemic effects for certain anti-rheumatic medications in a large retrospective observational study. METHODS Patients enrolled in the Veterans Affairs Rheumatoid Arthritis (VARA) registry were selected who, during follow-up, initiated treatment with tumor necrosis factor inhibitors (TNFi's, including etanercept, adalimumab, infliximab, golimumab, or certolizumab), prednisone, or conventional disease-modifying anti-rheumatic drugs(DMARDs), and for whom proximate random blood glucose (RBG) measurements were available within a window 2-wk prior to, and 6 mo following, medication initiation. Similar data were obtained for patients with proximate values available for glycosylated hemoglobin A1C values within a window 2 mo preceding, and 12 mo following, medication initiation. RBG and A1C measurements were compared before and after initiation events using paired t-tests, and multivariate regression analysis was performed including established comorbidities and demographics.RESULTS Two thousands one hundred and eleven patients contributed at least one proximate measurement surrounding the initiation of any examined medication. A significant decrease in RBG was noted surrounding 653 individual hydroxychloroquine-initiation events(-3.68 mg/dL, P = 0.04), while an increase was noted for RBG surrounding 665 prednisone-initiation events(+5.85 mg/d L, P < 0.01). A statistically significant decrease in A1C was noted for sulfasalazine initiation, as measured by 49 individual initiation events(-0.70%, P < 0.01). Multivariate regression analyses, using methotrexate as the referent, suggest sulfasalazine (β =-0.58, P = 0.01) and hydroxychloroquine(β =-5.78, P = 0.01) use as predictors of lower post-medicationinitiation RBG and A1C values, respectively. Analysis by drug class suggested prednisone (or glucocorticoids) as predictive of higher medication-initiation event RBG among all start events as compared to DMARDs, while this analysis did not show any drug class-level effect for TNFi. A diagnosis of congestive heart failure(β = 4.69, P = 0.03) was predictive for higher post-initiation RBG values among all medication-initiation events.CONCLUSION No statistically significant hypoglycemic effects surrounding TNFi initiation were observed in this large cohort. Sulfasalazine and hydroxychloroquine may have epidemiologically significant acute hypoglycemic effects. | Patrick R Wood Evan Manning Joshua F Baker Bryant England Lisa Davis Grant W Cannon Ted R Mikuls Liron Caplan | 2018 | World Journal of Diabetes2018，9，2： | 8 |
| 2 | Assessment of the Progress of the Back-Pain Patient显示文摘 | R MILLION W HALL K HAAVIK NILSEN R D BAKER M I V JAYSON | 1982 | Spine1982，，3： | 2 |
| 3 | The sensitivity of West African convective line water budgets to land cover显示文摘 | MOHR K I BAKER R D TAO W K | 2003 | J Hydrometeor2003，4，1： | 1 |
| 4 | The solution-diffusion model:a review显示文摘 | Wijmans J G Baker R W | | 0，，： | 1 |
| 5 | The passive film on iron: An application of Auger electron spectrosopy显示文摘 | Baker B G Bockris J O' M | 1975 | J Electrochem Soc1975，122，11： | 1 |
| 6 | Deficient cellular immunity in endometriosis 显示文摘 | Dmowski W P Steele R W Baker G F | 1981 | Am J Obstet Gynecol1981，141，4： | 1 |
| 7 | C-reactive protein in ischemic stroke and its etiologic subtypes 显示文摘 | Eikelboom J W Hankey G J Baker R I | 2003 | Stroke Cerebrovasc Dis2003，12，2： | 1 |
| 8 | Estimation of nutrient requirements from growth data显示文摘 | Robbins K R Norton H W Baker D H | 1979 | Nutr1979，109，： | 1 |
| 9 | Diffuse optics for tissue monitoring and tomography显示文摘 | Durduran T Choe R Baker W B | 2010 | Reporls on Progress in Physics2010，73，07： | 1 |
| 10 | Natural gas processing with membranes: An overview显示文摘 | Baker R W Lokhandwala K | 2008 | Industrial & Engineering Chemistry Research2008，47，7： | 1 |
| 11 | A symptom ratingscale for delirium显示文摘 | Trzepalz P T Baker R W Greenhoikse J | 1988 | Psychiatry Res1988，23，1： | 1 |
| 12 | The solution-diffusion model:a review显示文摘 | Wijmans J G Baker R W | 1995 | J Membr Sci1995，107，： | 1 |
| 13 | ^183W NMR of heteropoly and isopolytungstates explanations of chemical shifts and band assignments theoretical considerations 显示文摘 | ACERETE R HAMMER Ch F BAKER L C W | 1982 | J Chem Soc Dalton Trans1982，104，20： | 1 |
| 14 | Estimation of nutrient requirements from growth data 显示文摘 | Robbins K R Norton H W Baker D H | 1979 | J Nutr1979，109，： | 1 |
| 15 | Implementing potentially better practices to reduce lung injury in neonates显示文摘 | Burch K Rhine W Baker R | 2003 | Pediatrics2003，111，4： | 1 |
| 16 | Genome, transcriptome, and secretome analysis of wood decay fungus Postia placenta supports unique mechanisms of lignocellulose conversion 显示文摘 | Martinez D Challacombe J Morgenstern 1 Hibbett D Schmoll M Kubicek CP Ferreira P Ruiz-Duenas FJ Martinez AT Kersten P Hammel KE Wymelenberg AV Gaskell J Lindquist E Sabat G BonDurant SS Larrondo LF Canessa P Vicuna R Yadav J Doddapaneni H Subramanian V Pisabarro AG Lavin JL Oguiza JA Master E Henrissat B Coutinho PM Harris P Magnuson JK Baker SE Bruno K Kenealy W Hoegger PJ Kties U Ramaiya P kucas S Salamov A Shapiro H Tu H Chee CL Misra M Xie G Teter S Yaver D James T Mokrejs M Pospisek M Grigoriev IV Brettin T Rokhsar D Berka R Cullen D | 2009 | PNAS2009，106，6： | 1 |
| 17 | Multiple sclerosis and autoimmune diseases 显示文摘 | BAKER H W BALLA J I MACKAY I R | 1972 | Aus N Z J Med1972，2，： | 1 |
| 18 | The solution-diffusion model: A review显示文摘 | Wijmans J G Baker R W | 1995 | Journal of Membrane Science1995，107，： | 1 |
| 19 | Development of FlexSure HP--an immunochromatographic method to detect antibodies against Helicobacter pylori显示文摘 | Schrier W H Schoengold R J Baker J T | 1998 | Clin Chem1998，44，2： | 1 |
| 20 | Estimation of nutrient requirements from growth data显示文摘 | Robbins K R Norton H W Baker D H | 1979 | J Nutr1979，109，10： | 1 |
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