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| 1 | Dysregulation of innate immunity in ulcerative colitis patients who fail anti-tumor necrosis factor therapy显示文摘AIM To study the innate immune function in ulcerative colitis(UC) patients who fail to respond to anti-tumor necrosis factor(TNF) therapy.METHODS Effects of anti-TNF therapy, inflammation and medications on innate immune function were assessed by measuring peripheral blood mononuclear cell(PBMC) cytokine expression from 18 inflammatory bowel disease patients pre- and 3 mo post-anti-TNF therapy. Toll-like receptor(TLR) expression and cytokine production post TLR stimulation was assessed in UC 'responders'(n = 12) and 'non-responders'(n = 12) and compared to healthy controls(n = 12). Erythrocyte sedimentation rate(ESR) and C-reactive protein(CRP) levels were measured in blood to assess disease severity/activity and inflammation. Pro-inflammatory(TNF, IL-1β, IL-6), immuno-regulatory(IL-10), Th1(IL-12, IFNγ) and Th2(IL-9, IL-13, IL-17A) cytokine expression was measured with enzyme-linked immunosorbent assay while TLR cellular composition and intracellular signalling was assessed with FACS.RESULTS Prior to anti-TNF therapy, responders and nonresponders had similar level of disease severity and activity. PBMC's ability to respond to TLR stimulation was not affected by TNF therapy, patient's severity of the disease and inflammation or their medication use. At baseline, non-responders had elevated innate but not adaptive immune responses compared to responders(P < 0.05). Following TLR stimulation, nonresponders had consistently reduced innate cytokine responses to all TLRs compared to healthy controls(P < 0.01) and diminished TNF(P < 0.001) and IL-1β(P < 0.01) production compared to responders. This innate immune dysfunction was associated with reduced number of circulating plasmacytoid dendritic cells(p DCs)(P < 0.01) but increased number of CD4+ regulatory T cells(Tregs)(P = 0.03) as well as intracellular accumulation of IRAK4 in non-responders following TLR-2,-4 and-7 activation(P < 0.001). CONCLUSION Reduced innate immunity in non-responders may explain reduced efficacy to anti-TNF therapy. These serological markers may prove useful in predicting the outcome of costly anti-TNF therapy. | Angela C Baird Dominic Mallon Graham Radford-Smith Julien Boyer Thierry Piche Susan L Prescott Ian C Lawrance Meri K Tulic | 2016 | World Journal of Gastroenterology2016，22，41： | 10 |
| 2 | An integrated system for planning, navigation and robotic assistance for skull base surgery显示文摘BACKGROUND: We developed an image-guided robot system to provide mechanical assistance for skull base drilling,which is performed to gain access for some neurosurgical interventions, such as tumour resection. The motivation for introduc-ing this robot was to improve safety by preventing the surgeon from accidentally damaging critical neurovascular structures dur- | Baird C Jallo G Hayes K Nakajima N Hata N Kazanzides P | 2008 | 中国神经肿瘤杂志2008，6，3： | 6 |
| 3 | OxLDL induced cell death is inhibited by the macrophage synthesised pterin,7,8-dihydroneopterin,in U937 cells but not THP-1 cells显示文摘 | BAIRD S K REID L HAMPTON M B | 2005 | Biochem Biophys Acta2005，1745，： | 1 |
| 4 | National Public Health Perform- ance Standards Assessment: First Steps in Strengthening North Dakota's Public Health System 显示文摘 | Baird B J Carlson J K | 2005 | J Public Health Management Practice2005，11，5： | 1 |
| 5 | Effects of synthetic and naturally occurring flavonoids on metabolic activation of benzopyrene in hamster embryo cell cultures显示文摘 | CHAE Y H HO D K CASSADY J M COOK V M MARCUS C B BAIRD W M | 1992 | Chemico-biological Interactions1992，82，2： | 1 |
| 6 | Spatial structure and habitat variation in a grasshopper hybrid zone显示文摘 | Bridle J R Baird S J E Butlin R K | 2001 | Evolution2001，55，9： | 1 |
| 7 | Estimating nuclear DNAcontent in peach and related diploid species using laser flow cytome-try and DNA hybridization显示文摘 | BAIRD W V ESTAGER A S WELLS J K | 1994 | Journal of the American Society forHorticultural Science1994，119，6： | 1 |
| 8 | Medical management of intracerebral hemorrhage 显示文摘 | Butcher K Baird T Parsons M | 2002 | Neurosurg Q2002，12，4： | 1 |
| 9 | Meta-analysis of periodontal disease and risk of coronary heart disease and stroke显示文摘 | Janket S J Baird A E Chuang S K | 2003 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2003，95，5： | 1 |
| 10 | Elecrical behavior of a simple helical flux compression generator for code benchmarking 显示文摘 | Neuber A Cornette J B Jamison K Parkinson E R Giesselmann M Worsey P Baird J Schmidt M Kristiansen | 2001 | IEEE Transactions on Plasma Science2001，29，4： | 1 |
| 11 | Primaquine:Report from CDC expert meeting on malaria chemoprophylaxis I显示文摘 | Hill DR Baird J K Parise ME | 2006 | Am J Trop Med Hyg2006，75，3： | 1 |
| 12 | Medical management of intracerebral hemorrhage显示文摘 | Butcher K Baird T Parsons M | 2002 | Neurosurg Quart2002，12，4： | 1 |
| 13 | Inhibin A is a follicle stimulating hormone responsive marker of granulosa cell differentiation, which has both au- tocrine and paracrine actions in sheep 显示文摘 | Campbell B K Baird D T | 2001 | J Endocrinol2001，169，： | 1 |
| 14 | Construction of saturated linkage maps of peach crosses segregating for characters controlling fruit quality, tree architecture andpest resistance显示文摘 | ABBOTT A G RAJAPAKSE S SOSINSKI B LU Z X SOSSEY- ALAOUI K GANNAVARPU M REIGHARD BALLARD R E BAIRD W V SCORZA R CALLAHAN A | 1998 | Aeta Horticulturae1998，465，： | 1 |
| 15 | Maintenance of 3T3-L1cells in culture media containing saturated fatty acids decreases insulin binding and insulin action显示文摘 | GRUNFELD C BAIRD K L KAHN C R | 1981 | Biochem Biophys Res Commun1981，103，1： | 1 |
| 16 | Estimating nuclear DNA con- tent in peach and related diploid species using laser flow cytometry and DNA hybridization 显示文摘 | Baird W V Estager A S Wells J K | 1994 | J Amer Soc Hort Sci1994，119，6： | 1 |
| 17 | Laboratory toxicity test and post-exposure feeding inhibition using the giant freshwater prawn Macrobrachium rosenbergii 显示文摘 | Satapornvanit K Baird D J Little D C | 2009 | Chemosphere2009，74，9： | 1 |
| 18 | A medium for the presunptive detection of Enterobacter sakazaki in infant formula 显示文摘 | Leuscher R C K Baird F Donald B | 2004 | Food Microbiol2004，21，： | 1 |
| 19 | Uterin contractility induction of abortion in early pregnacy by misoprostol and mifepristone显示文摘 | NORMAL J E THONG K J BAIRD D T | 1991 | Lancet1991，338，1： | 1 |
| 20 | Medical management of intracerebral hemorrhage 显示文摘 | Butcher K Baird T Parsons M | 2002 | Neurosurg Q2002，12，4： | 1 |
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