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| 1 | In vitro effect of pantoprazole on lower esophageal sphincter tone in rats显示文摘AIM:To investigate the in vitro effects of pantoprazole on rat lower esophageal sphincter(LES)tone.METHODS:Rats weighing 250-300 g,provided by the Yeditepe University Experimental Research Center(Yü-DETAM),were used throughout the study.They were anesthetized before decapitation.LES tissues whose mucosal lining were removed were placed in a stan-dard 30-mL organ bath with a modif ied Krebs solution and continuously aerated with 95% oxygen-5% carbon dioxide gas mixture and kept at room temperature.The tissues were allowed to stabilize for 60 min.Sub-sequently,the contractile response to 10-6 mol/L carba-chol was obtained.Different concentrations of freshly prepared pantoprazole were added directly to the tis-sue bath to generate cumulative concentrations of 5×10-6 mol/L,5×10-5 mol/L,and 1.5×10-4 mol/L.Activi-ties were recorded on an online computer via a 4-channeltransducer data acquisition system using the software BSL PRO v 3.7,which also analyzed the data.RESULTS:Pantoprazole at 5×10-6 mol/L caused a small,but statistically insignif icant,relaxation in the car-bachol-contracted LES(2.23% vs 3.95%).The 5×10-5 mol/L concentration,however,caused a signif icant relax-ation of 10.47% compared with the control.1.5×10-4 mol/L concentration of pantoprazol caused a 19.89% relaxation in the carbachol contracted LES(P<0.001).CONCLUSION:This is the fi rst study to demonstrate that pantoprazole has a relaxing effect in isolated LESs.These results might have signif icant clinical implications for the subset of patients using proton pump inhibitors who do not receive full symptomatic alleviation from gastroesophageal reflux disease. | Mustafa Duman Mahmut zer Enver Rean Yeliz Demirci Ali E Atιcι Tahsin Dalgι Erdal B Bostancι Ece Gen | 2011 | World Journal of Gastroenterology2011，17，46： | 3 |
| 2 | Total cavopulmonary conversion and maze procedure for patients with failure of the Fontan operation显示文摘 | Mavroudis C Backer CL Deal BJ at al | 2001 | J Thorac Cardiovasc Surg2001，122，5： | 2 |
| 3 | Community- acquired Staphylococcus aureus pneumonia following influenza and the choice of empirical antibiotic treatment显示文摘 | van Nieuwkoop C Bernards AT Compier EA | 2008 | Ned Tijdschr Geneeskd2008，152，14： | 1 |
| 4 | Fiber-to-the-home services based on wavelength-division-multiplexing passive optical network 显示文摘 | PARK S J LEE C H JEONG K T et at | 2004 | Journal of Lightwave Technology2004，22，11： | 1 |
| 5 | Characterization and degradation behavior of AZ31 alloy surface modified by bone-like hydroxyapatite for implant applications显示文摘 | Wen C L Guan S K Peng L et at | 2009 | Applied Surface Science2009，255，1314： | 1 |
| 6 | Deplo- ying multiple interconnected gateways in heterogeneous wireless sensor networks : An optimization approach 显示文摘 | ANTONIO C MAq'FEO C DANILO D D et at | 2010 | Computer Communications2010，33，： | 1 |
| 7 | Benign central neurocytoma显示文摘 | Ashkan K Casey AT D'Arrigo C | 2009 | Cancer2009，89，5： | 1 |
| 8 | Prospective identification of tumorigenic prostate cancer stem cells 显示文摘 | Collins AT Berry PA Hyde C Stower MJ Maitland NJ | 2005 | Cancer Res2005，65，10： | 1 |
| 9 | Identification of pancreatic stem cells显示文摘 | Li C Heidt DG Dalerba P et at | 2007 | Cancer Res2007，67，3： | 1 |
| 10 | Pathways of load-induced cartilage damage causing cartilage degeneration in the knee after meniscectomy显示文摘 | Wilson W van-Riethergen B van-Donkelaar C C et at | 2003 | J Biomech2003，36，6： | 1 |
| 11 | Glucose and lepfin induce apoptesis in human beta - cells and impair glucose - stimulated insuli - n secretion through activation of c - Jun N - terminal kina - ses 显示文摘 | Macdler K Sehulthess FT Bielman C et at | 2008 | FASEB J2008，22，： | 1 |
| 12 | Adverse effects ofvor/conazole : a- nalysis of the French pharmacovigilance database 显示文摘 | Eiden C Peyriere H Cociglio M et at | 2007 | Ann Pharmacoth- er2007，41，5： | 1 |
| 13 | Liver transplantation is not curative for methylmalonic acidopathy caused by methyl- malonyl-CoA mutase deficiency 显示文摘 | Kaplan P Ficicioglu C Mazur AT | 2006 | Mol Genet Metal)2006，88，4： | 1 |
| 14 | Enhanced tibial osteotomy healing with use of bone grafts supplemented with platelet gel or platelet gel and bone mar?row stromal cells显示文摘 | Dallari D Savarino L Stagni C et at | 2007 | J BoneJoint Surg Am2007，89，11： | 1 |
| 15 | Cancer treatment and survivorship statistics显示文摘 | SIEGEL R DESANTIS C VIRGO K et at | 2012 | Cancer J Clin2012，62，4： | 1 |
| 16 | Correlates and outcomes of fatigue among incident dialysis patients显示文摘 | jhamh M Argyropoulos C Steel JL et at | 2009 | Clin J Am Soc Nephrol2009，，： | 1 |
| 17 | Evaluation of plasma membrane integrity of frozen-thawed goat spermatozoa with or without seminal plasma显示文摘 | Azeredo G A Esper C R Resende K T at al | 2001 | SmallRuminant Research2001，41，3： | 1 |
| 18 | Frozen shoulder: MRarthrographic findings显示文摘 | Mengiardi B- Pfirrrmnn CW Gerber C et at | 2004 | Radiology2004，2，： | 1 |
| 19 | Dynamic interspinous process stabilization:Review of complications associated with the X-STOP device显示文摘 | Bowers C Amini A Dailey AT | | 0，，06： | 1 |
| 20 | Arginase inhibition me diates cardioprotection during ischaemia-reperfusion 显示文摘 | Jung C Gonon AT Sjoquist PO etal | 2010 | Card- iovasc Res2010，85，： | 1 |
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