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| 1 | Sampling error and intraobserver variation in liver biopsy in patients with chronic HCV infection显示文摘 | Arie Regev Mariana Berho Lennox J Jeffers Clara Milikowski Enrique G Molina Nikolaos T Pyrsopoulos Zheng-Zhou Feng K.Rajender Reddy Eugene R Schiff | 2002 | The American Journal of Gastroenterology2002，，10： | 7 |
| 2 | Integrating TYMS, KRAS and BRAF testing in patients with metastatic colorectal cancer显示文摘AIM To investigate the impact of thymidylate synthase(TYMS), KRAS and BRAF in the survival of metastatic colorectal cancer(m CRC) patients treated with chemotherapy. METHODS Clinical data were collected retrospectively from records of consecutive patients with m CRC treated with fluoropyrimidine-based chemotherapy from 1/2005 to 1/2007. Formalin-fixed paraffin-embedded tissues were retrieved for analysis. TYMS genotypes were identified with restriction fragment analysis PCR, while KRAS and BRAF mutation status was evaluated using real-time PCR assays. TYMS gene polymorphisms of each of the 3' untranslated region(UTR) and 5'UTR were classified into three groups according to the probability they have for high, medium and low TYMS expression(and similar levels of risk) based on evidence from previous studies. Univariate and multivariate survival analyses were performed.RESULTS The analysis recovered 89 patients with m CRC(46.1% de novo metastatic disease and 53.9% relapsed). Of these, 46 patients(51.7%) had colon cancer and 43(48.3%) rectal cancer as primary. All patients were treated with fluoropyrimidine-based chemotherapy(5FU or capecitabine) as single-agent or in combination with irinotecan or/and oxaliplatin or/and bevacizumab. With a median follow-up time of 14.8 mo(range 0-119.8), 85 patients(95.5%) experienced disease progression, and 63 deaths(70.8%) were recorded. The 3-year and 5-year OS rate was 25.4% and 7.7% while the 3-year progression-free survival rate was 7.1%. Multivariate analysis of TYMS polymorphisms, KRAS and BRAF with clinicopathological parameters indicated that TYMS 3'UTR polymorphisms are associated with risk for disease progression and death(P < 0.05 and P < 0.03 respectively). When compared to tumors without any del allele(genotypes ins/ins and ins/loss of heterozygosity(LOH) linked with high TYMS expression) tumors with del/del genotype(low expression group) and tumors with ins/del or del/LOH(intermediate expression group) have lower risk for disease progression(HR = 0.432, 95%CI: 0.198-0.946, P < 0.04 and HR = 0.513, 95%CI: 0.287-0.919, P < 0.03 respectively) and death(HR = 0.366, 95%CI: 0.162-0.827, P < 0.02 and HR = 0.559, 95%CI: 0.309-1.113, P < 0.06 respectively). Additionally,KRAS mutation was associated independently with the risk of disease progression(HR = 1.600, 95%CI: 1.011-2.531, P < 0.05). The addition of irinotecan in 1st line chemotherapy was associated independently with lower risk for disease progression and death(HR = 0.600, 95%CI: 0.372-0.969, P < 0.04 and HR = 0.352, 95%CI: 0.164-0.757, P < 0.01 respectively).CONCLUSION The TYMS genotypes ins/ins and ins/LOH associate with worst prognosis in m CRC patients under fluoropyrimidine-based chemotherapy. Large prospective studies are needed for validation of our findings. | Anastasios Ntavatzikos Aris Spathis Paul Patapis Nikolaos Machairas George Peros Stefanos Konstantoudakis Danai Leventakou Ioannis G Panayiotides Petros Karakitsos Anna Koumarianou | 2017 | World Journal of Gastroenterology2017，23，32： | 4 |
| 3 | Large cystic lesions of the liver in adults: a 15-year experience in a tertiary center 1 1 No competing interests declared.显示文摘 | Arie Regev K.Rajender Reddy Mariana Berho Dan Sleeman Joe U Levi Alan S Livingstone David Levi Unzila Ali Enrique G Molina Eugene R Schiff | 2001 | Journal of the American College of Surgeons2001，，1： | 2 |
| 4 | Outcomes of revision external dacryocystorhinostomy and nasal intubation by bicanalicular silicone tubing under endonasal endoscopic guidance显示文摘AIM: To evaluate the long-term treatment outcomes in patients who underwent revision of external dacryocysto- rhinostomy (DCR) and nasal intubation by bicanalicular silicone tubing (BSTI) under endonasal endoscopic guidance. · METHODS: Data from 28 patients with recurrent dacryocystitis were retrospectively reviewed. Revision external DCR and bicanalicular nasal intubation by silicone tubing under endonasal endoscopic guidance was performed in 28 eyes of 28 patients. The patients were evaluated with respect to the reason of recurrence, time to recurrence, time to revision, duration of follow-up and surgical success. · RESULTS: Endoscopic endonasal examination detected an osteotomy-side obstruction by the excessive granulation tissue in 24 patients (86%), nasal septal deviation in three patients (10%) and nasal polyp in one patient (4%). Recurrence occurred after a mean duration of 5.3±3.7 months following the first operation. The mean time between the first DCR operation and the revision DCR was 11.5 ± 9.3 months. After a mean follow-up of 14.9±7.8 months, the rate of anatomic success alone was 85% (24/28); the rate of subjective success was 78% (22/28). · CONCLUSION: Revision external DCR and bicanalicular nasal intubation by silicone tubing under endonasal endoscopic guidance can be recommended in patients with recurrent dacryocystitis as a surgical approach that achieves satisfactory objective and subjective success rates. | Seyhmus Ari Abdullah Kürsat Cingü Alparslan Sahin Ramazan Gün Vefa Kinis ihsan aa | 2012 | International Journal of Ophthalmology(English edition)2012，5，2： | 2 |
| 5 | Synthesis and characterization of Dy-Eu-Tm co-doped cubic phase stabilized bismuth oxide based electrolytes in terms of intermediate temperature-solid oxide fuel cells(IT-SOFCs)显示文摘In this study,a new Dy-Eu-Tm co-doped cubic phase stabilized bismuth oxide solid electrolyte system was synthesized by using solid-state reaction method in atmospheric conditions.Before conductivity measurements,X-ray diffraction(XRD)pro files of the annealed samples show that created mixtures have heterogeneous phase,but after conductivity measurements,the face-centered cubic(FCC)crystal structure is stabilized for all samples.Also,the increase in total dopant rate causes an increase in full width half maxima(FWHM)of main peak(111)on the XRD pattern while average crystal size decreases with it.On the other hand,the highest conductivity value was obtained for the sample having 15%total dopant rate with 0.62 S/cm at 750℃,whose dopants are evenly distributed in mole percent.Differential thermal analysis(DTA)results of the samples having 1:1:1 and 1:2:1 dopant content ratios show that endothermic peak occurs on their DTA curve,indicating crystal structure transformation such as phase transition or order-disorder transition.Also,thermo-gravimetric analysis(TGA)depending on temperature was evaluated in terms of mass loss.According to TGA curves,mass loss for both heating and cooling process can be negligible due to the small fluctuations(2%)on their TGA curves. | Ayhan Güldeste Mustafa Aldoori Murat Balci Mehmet Ari Yasin Polat | 2023 | Journal of Rare Earths2023，41，3： | 2 |
| 6 | Validation of a blind transpyloric feeding- tube placement technique in pediatric intensive care : Rapid, simple, and highly successful 显示文摘 | Ari R Melanie G | 2000 | Pediatr CritCare Med2000，1，2： | 1 |
| 7 | Failure criteria for brittle elastic material 显示文摘 | ZOHAR Y ARIE B ILAN G | 2004 | International Journal of Fracture2004，125，3： | 1 |
| 8 | Simulation as decision tool for capacity planning显示文摘 | Siebren Droothuis Godefridus G van' Merode Arie Hasman | 2001 | Computer Methods and Programs in Biomedicine2001，，66： | 1 |
| 9 | Mineral absorption and excretion as affected by microbial phytase,and their effect on energy metabolism in young piglets 显示文摘 | Arie K K Walter J J G Johan W S | 2005 | J Nutr2005，135，： | 1 |
| 10 | CD74 is a member of the regulated intramembrane proteolysisprocessed protein family 显示文摘 | Becker-Herman S Arie G Medvedovsky H | 2005 | Mol Biol Cell2005，16，11： | 1 |
| 11 | Hematocrit and hemoglobin concen- tration in four chromosomal species and some isolated populations of ac- tively speciating subterranean mole rats in israel显示文摘 | ARIELI R HETH G NEVO E | 1986 | Experientia1986，42，4： | 1 |
| 12 | Preparation of polyaniline-TiO: composite and its com- parative corrosion protection performance with polyaniline 显示文摘 | SATHIYANARAYANAN S SYEDd Azim S VENKATACH- ARI G | 2007 | Synthetic Metals2007，157，4： | 1 |
| 13 | Face stability conditions earth-pressure-balanced shields显示文摘 | Anagnostou G Kov'ari K | 1996 | Tunneling and Underground Space Technology1996，11，2： | 1 |
| 14 | Modelling of Spontaneous Ignition of Coal Stockpiles 显示文摘 | salinger A G Aris R Derby J J | 1994 | AIChE Journal1994，40，6： | 1 |
| 15 | Control of soil- borne clubroot disease of cruciferous plants by epoxydon from Phoma glomerata显示文摘 | Arie T Kobayashi Y Okada G | 1998 | Plant Pathol1998，47，6： | 1 |
| 16 | Pulsatile intracranial pressure and cerebral autoregulation after traumatic brain injury 显示文摘 | RADOLOVICH D K ARIES M J CASTELLANI G | 2011 | Neurocrit Care2011，15，3： | 1 |
| 17 | Simulation as decision tool for capacity planning显示文摘 | Siebren Droothuis Godefridus G van Merode Arie Hasman | 2001 | Computer Methods and Programs in Biomedicine2001，，66： | 1 |
| 18 | Anti-diabetic effects of onion and garlic sulfoxideam ino acids inrats 显示文摘 | Sheela C G Kum ari K Augusti K T | 1995 | Planta Medica1995，61，4： | 1 |
| 19 | Neuromarketing: The hope and hype of neuroimaging in business显示文摘 | Ariely D Berns G S | 2010 | Nature Reviews Neuroscience2010，11，4： | 1 |
| 20 | Control of soil borne clubro- ~t disease of craciferous plants by epoxydon from Phoma glomerata 显示文摘 | Arie T Kobayashi Y Okada G | 1998 | Plant Pathology1998，47，6： | 1 |
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