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| 1 | Radiofrequency ablation for treatment of hypersplenism: A feasible therapeutic option显示文摘We present a case of a patient with hypersplenism secondary to portal hypertension due to hepato-splenic schistosomiasis, which was accompanied by severe and refractory thrombocytopenia. We performed spleen ablation and measured the total spleen and ablated volumes with contrast-enhanced computed tomography and volumetry. No major complications occurred, thrombocytopenia was resolved, and platelet levels remained stable, which allowed for early treatment of the patient's underlying disease. Previous work has shown that splenic radiofrequency ablation is an attractive alternative treatment for hypersplenism induced by liver cirrhosis. We aimed to contribute to the currently sparse literature evaluating the role of radiofrequency ablation(RFA) in the management of hypersplenism. We conclude that splenic RFA appears to be a viable and promising option for the treatment of hypersplenism. | Guilherme Lopes P Martins Joao Paulo G Bernardes Marcello S Rovella Raphael G Andrade Publio Cesar C Viana Paulo Herman Giovanni Guido Cerri Marcos Roberto Menezes | 2015 | World Journal of Gastroenterology2015，21，20： | 17 |
| 2 | Concordance of non-invasive mechanical and serum tests for liver fibrosis evaluation in chronic hepatitis C显示文摘AIM To determine the sensitivity and specificity of liver stiffness measurement(LSM) and serum markers(SM) for liver fibrosis evaluation in chronic hepatitis C.METHODS Between 2012 and 2014,81 consecutive hepatitis C virus(HCV) patients had METAVIR score from liver biopsy compared with concurrent results from LSM [transient elastography(TE) [FibroS can~/ARFI technology(Virtual Touch~)] and SM [FIB-4/aspartate aminotransferase-toplatelet ratio index(APRI)].The diagnostic performance of these tests was assessed using receiver operating characteristic curves.The optimal cut-off levels of each test were chosen to define fibrosis stages F ≥ 2,F ≥ 3 and F = 4.The Kappa index set the concordance analysis.RESULTS Fifty point six percent were female and the median age was 51 years(30-78).Fifty-six patients(70%) weretreatment-na?ve.The optimal cut-off values for predicting F ≥ 2 stage fibrosis assessed by TE were 6.6 kP a,for acoustic radiation force impulse(ARFI) 1.22 m/s,for APRI 0.75 and for FIB-4 1.47.For F ≥ 3 TE was 8.9 kP a,ARFI was 1.48 m/s,APRI was 0.75,and FIB-4 was 2.For F = 4,TE was 12.2 kP a,ARFI was 1.77 m/s,APRI was 1.46,and FIB-4 was 3.91.The APRI could not distinguish between F2 and F3,P = 0.92.The negative predictive value for F = 4 for TE and ARFI was 100%.Kappa index values for F ≥ 3 METAVIR score for TE,ARFI and FIB-4 were 0.687,0.606 and 0.654,respectively.This demonstrates strong concordance between all three screening methods,and moderate to strong concordance between them and APRI(Kappa index = 0.507).CONCLUSION Given the costs and accessibility of LSM methods,and the similarity with the outcomes of SM,we suggest that FIB-4 as well as TE and ARFI may be useful indicators of the degree of liver fibrosis.This is of particular importance to developing countries. | Denise C Paranaguá-Vezozzo Adriana Andrade Daniel F C Mazo Vinicius Nunes Ana L Guedes Taisa G Ragazzo Renata Moutinho Lucas S Nacif Suzane K Ono Venancio A F Alves Flair J Carrilho | 2017 | World Journal of Hepatology2017，9，8： | 7 |
| 3 | Is autoimmune hepatitis a frequent finding among HCV patients with intense interface hepatitis?显示文摘AIM:To evaluate the overlap of autoimmune hepatitis in hepatitis C virus(HCV)-infected patients with intense interface hepatitis.METHODS:Among 1759 patients with hepatitis C submitted to liver biopsy,92(5.2%) presented intense interface hepatitis.These patients were evaluated regarding the presence of antinuclear antibody(ANA),anti-smooth muscle antibody(SMA) and anti-liver/kidney microsomal antibody(LKM-1),levels of γ-globulin and histological findings related to autoimmune hepatitis(plasma cell infiltrate and presence of rosettes).RESULTS:Among patients with hepatitis C and intense interface hepatitis there was a low prevalence of autoantibodies(ANA=12%,SMA=5%,LKM-1=0%) and the median γ-globulin level was within the normal range.Typical histological findings of autoimmune disease were observed in only two cases(2%).After applying the score for diagnosis of autoimmune hepatitis,only one patient was classified with a definitive diagnosis of autoimmune hepatitis.Since overlap with autoimmune hepatitis was not the explanation for the intense necroinflammatory activity in patients with chronic hepatitis C we sought to identify the variables associated with this finding.The presence of intense interface hepatitis was associated with more advanced age,both at the time of infection and at the time of the biopsy,and higher prevalence of blood transfusion and alcohol abuse.CONCLUSION:Although possible,overlap with autoimmune hepatitis is a very rare association in HCV-infected patients with intense interface hepatitis,an unusual presentation which seems to be related to other host variables. | Rosilene G Badiani Vitória Becker Renata M Perez Carla AL Matos Lara B Lemos Valéria P Lanzoni Luis Eduardo C Andrade Alessandra Dellavance Antonio Eduardo B Silva Maria Lucia G Ferraz | 2010 | World Journal of Gastroenterology2010，16，29： | 7 |
| 4 | Wind velocity and sand transport on a barchan dune显示文摘 | G Sauermann J.S Andrade L.P Maia U.M.S Costa A.D Araújo H.J Herrmann | 2003 | Geomorphology2003，，3： | 2 |
| 5 | Proteomic anal- ysis of the cambial region in juvenile Eucalyptus grandis at three ages 显示文摘 | Celedon P A F de Andrade A Meireles K G X | 2007 | Proteomics2007，7，13： | 1 |
| 6 | The influence of thermal cycling on the transition temperatures of a Fe-Mn-Si shape memory alloy显示文摘 | Andrade M S Osthues R M Arruda G J | 1999 | Materials Science and Engineering A1999，，： | 1 |
| 7 | Chloride penetration into concrete structures in the marine atmosphere zone: relationship between deposition of chlorides on the wet candle and chlorides accumulated into concrete 显示文摘 | MEIRA G R ANDRADE C PADARATZ I J | 2007 | Cement and Concrete Composites2007，29，9： | 1 |
| 8 | Chemical composition of lipophilic extractives from jute (Corchorus capsularis)fibers used for manufacturing of high-quality paper pulps 显示文摘 | Rio Andrade J C Marques G Rodriguez Garcia M I | 2009 | Industrial Crops and Products2009，30，： | 1 |
| 9 | Chloride penetration into concrete structures in the marine atmosphere zone: Relationship between deposition of chlorides on the wet candle and chlorides accumulated into concrete显示文摘 | MEIRA G R ANDRADE C PADARATZ I J | 2007 | Cement Concrete Composites2007，29，9： | 1 |
| 10 | Acute leukemia after infliximab therapy显示文摘 | Alcain G Andrade RJ de Llano MP Q | | 0，，： | 1 |
| 11 | Thermo-rheological behavior of model protein-polysaccharide mixtures 显示文摘 | Andrade R J Azevedo A G Musampa R M | 2010 | Rheologica Acta2010，49，4： | 1 |
| 12 | Preliminary study offlavonols in port wine grape varieties 显示文摘 | ANDRADE P B MENDES G FALCO V | 2001 | Food Chem2001，73，4： | 1 |
| 13 | Comparison of six-minute walk test in children with moderate/ severe asthma with reference values for healthy children显示文摘 | ANDRADE L B SILV A R G SALGADO T L B | 2014 | Jomal de Pediatria2014，90，3： | 1 |
| 14 | Mutation rates at 14 STR loci in the population from Pernambuco, Northeast Brazil显示文摘 | Andrade ES Comes EV Raposo G | 2009 | Forensic Sci Int Genet2009，3，4： | 1 |
| 15 | Halbach Array Supercon- ducting Magnetic Bearing for a Flywheel Energy Storage System 显示文摘 | Sotelo G G Ferreira A C Andrade R J | 2005 | IEEE Transactions on Applied Superconductivity2005，6，15： | 1 |
| 16 | How costly is financial (not eco- nomic) distress? Evidence from highly leveraged transactions that became distressed 显示文摘 | ANDRADE G KAPLAN S N | 1998 | Journal o f Finance1998，53，5： | 1 |
| 17 | Activation of the PI3K/Akt pathway early during vaccinia and cowpox virus infections is required for both host survival and viral replication 显示文摘 | SOARES J A LEITE F G ANDRADE L G | 2009 | J Virol2009，83，13： | 1 |
| 18 | Serum - induced macrophage activation is related to the severeity of septic shock 显示文摘 | Peck G Andrades M Lorenzi R | 2009 | Inflamm Res2009，58，2： | 1 |
| 19 | Probing surface microheterogeneity of poly (ether urethanes) in an aqueous environment显示文摘 | TINGEY K G ANDRADE J D | 1991 | Langmuir1991，7，： | 1 |
| 20 | SMAS graft of the nasolabial area during deep plane rhytidectomy显示文摘 | Calderon W Andrades PR Israel G | 2004 | Plast Reconstr Surg2004，114，2： | 1 |
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