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| 1 | Value of a newly sequenced bacterial genome显示文摘Next-generation sequencing(NGS) technologies have made high-throughput sequencing available to medium- and small-size laboratories, culminating in a tidal wave of genomic information. The quantity of sequenced bacterial genomes has not only brought excitement to the field of genomics but also heightened expectations that NGS would boost antibacterial discovery and vaccine development. Although many possible drug and vaccine targets have been discovered, the success rate of genome-based analysis has remained below expectations. Furthermore, NGS has had consequences for genome quality, resulting in an exponential increase in draft(partial data) genome deposits in public databases. If no further interests are expressed for a particular bacterial genome, it is more likely that the sequencing of its genome will be limited to a draft stage, and the painstaking tasks of completing the sequencing of its genome and annotation will not be undertaken. It is important to know what is lost when we settle for a draft genome and to determine the 'scientific value' of a newly sequenced genome. This review addresses the expected impact of newly sequenced genomes on antibacterial discovery and vaccinology. Also, it discusses the factors that could be leading to the increase in the number of draft deposits and the consequent loss of relevant biological information. | Eudes GV Barbosa Flavia F Aburjaile Rommel TJ Ramos Adriana R Carneiro Yves Le Loir Jan Baumbach Anderson Miyoshi Artur Silva Vasco Azevedo | 2014 | World Journal of Biological Chemistry2014，5，2： | 7 |
| 2 | 持续气道正压通气在预防阻塞性睡眠呼吸暂停患者心血管事件中的作用显示文摘阻塞性睡眠呼吸暂停(obstructive sleep apnea,OSA)导致阵发性低氧血症,夜间交感神经系统激活,血压、氧化应激和炎症指标的升高以及高凝血症。较大的胸内负压波动也会给心脏和大血管施加机械应力。基于人群和睡眠诊所的队列研究显示,OSA与心脑血管事件,特别是脑卒中相关。 | McEvoy RD Antic NA Heeley E Luo Y Ou Q Zhang X Mediano O Chen R Drager LF Liu Z Chen G Du B McArdle N Mukherjee S Tripathi M Billot L Li Q Lorenzi-Filho G Barbe F Redline S Wang J Arima H Neal B White DP Grunstein RR Zhong N Anderson CS 练桂丽 叶鹏 | 2016 | 中华高血压杂志2016，24，11： | 4 |
| 3 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 4 | Reduced striatal volumes in Parkinson’s disease:a magnetic resonance imaging study显示文摘Background:The presence and extent of structural changes in the brain as a consequence of Parkinson’s disease(PD)is still poorly understood.Methods:High-resolution 3-tesla T1-weighted structural magnetic resonance images in sixty-five PD and 27 age-matched healthy control participants were examined.Putamen,caudate,and intracranial volumes were manually traced in the axial plane of 3D reconstructed images.Striatal nuclei volumes were normalized to intracranial volume for statistical comparison.Disease status was assessed using the Unified Parkinson’s Disease Rating Scale and Hoehn and Yahr scale.Cognitive status was assessed using global status tests and detailed neuropsychological testing.Results:Both caudate and putamen volumes were smaller in PD brains compared to controls after adjusting for age and gender.Caudate volumes were reduced by 11%(p=0.001)and putamen volumes by 8.1%(p=0.025).PD striatal volumes were not found to be significantly correlated with cognitive or motor decline.Conclusion:Small,but significant reductions in the volume of both the caudate and putamen occur in PD brains.These reductions are independent of the effects of age and gender,however the relation of these reductions to the functional loss of dopamine,which is characteristic of PD,remains unclear. | Toni L Pitcher Tracy R Melzer Michael R MacAskill Charlotte F Graham Leslie Livingston Ross J Keenan Richard Watts John C Dalrymple-Alford Tim J Anderson | 2012 | Translational Neurodegeneration2012，1，1： | 2 |
| 5 | Unfrozen water contents of submarine permafrost determined by nuclear magnetic resonance 显示文摘 | Tice A R Anderson D M Sterrett K F | 1981 | Engineering Geology1981，18，： | 2 |
| 6 | In formation hiding a survey 显示文摘 | Petitcolas F A P Anderson R J Kulm M G | 1999 | IEEE Special Issue on Protection of Multimedia Content1999，87，7： | 1 |
| 7 | Wetting collapse in openeast coalrnine backfill 显示文摘 | Blanchfield R Anderson W F | 2000 | Proc of Instit of Civil Eng Geotech Eng2000，143，3： | 1 |
| 8 | AI- MS2:the content and properties of a revised and expanded arthritis impact measurement scales health status ques- tionnaire显示文摘 | MEENAN R F MASON J H ANDERSON J J | 1992 | Arthritis Rheum1992，35，1： | 1 |
| 9 | Free radicals and ocular disease显示文摘 | ANDERSON R E KRETZER F L RAPP L M | 1994 | Adv Exp Med Biol1994，366，： | 1 |
| 10 | Information hiding-a survey显示文摘 | Petitcolas F A P Anderson R J Kuhn M G | 1999 | Proc of IEEE1999，87，7： | 1 |
| 11 | Remobilization of authigenic uranium in marine sediments by bioturbation 显示文摘 | ZHENG Y ANDERSON R F VAN GEEN A | 2002 | Geochimica et Cosmochimica Acta2002，66，： | 1 |
| 12 | Information hiding-A survey 显示文摘 | F A P Petitcolas R J Anderson M G Kuhn | 1999 | Proceedings of the IEEE1999，87，7： | 1 |
| 13 | Gelatinization of corn grits by roll cooking,extrusion cooking and steaming显示文摘 | Anderson R A Conway H F Peplinski A J | | 0，，： | 1 |
| 14 | A critical review of two- phase flow in gas flow channels of proton exchange membrane fuel cells显示文摘 | Anderson R Zhang L F Ding Y L | 2010 | J Power Sources2010，195，15： | 1 |
| 15 | Information Hiding-A Survey显示文摘 | Petitcolas P F A P Anderson R J Kuhn M G | 1999 | Proceedings of the IEEE Special Issue on Protection of Multimedia Content1999，87，7： | 1 |
| 16 | On the Limits of Steganography显示文摘 | R J Anderson F A P Petitcolas | 1998 | IEEE Journal of Selected Areas in Communications Special Issue on Copyright and Privacy Protection1998，16，4： | 1 |
| 17 | The ethylene biosynthesis inducing xylanase: its induction in Trichoderma viride and certain plant pathogens显示文摘 | DEAN J F D GAMBLE H R ANDERSON J D | 1989 | Phytopathology1989，，79： | 1 |
| 18 | Information hiding-a survey显示文摘 | PETITCOLAS F ANDERSON R KUHN M | 1999 | Proceedings of the IEEE1999，87，7： | 1 |
| 19 | Effects sizes for interpreting changes in health status显示文摘 | Kazis L E Anderson J J Meenan R F | 1989 | Med Care1989，27，3： | 1 |
| 20 | Information hiding-a survey显示文摘 | Petitcolas F A P Anderson R J Kuhn M G | 1999 | Proceedings of the IEEE1999，87，7： | 1 |
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