|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Evaluation of C-reactive protein, an inflammatory marker, and infectious serology as risk factors for coronary artery disease and myocardial infarction显示文摘 | Jeffrey L Anderson John F Carlquist Joseph B Muhlestein Benjamin D Horne Sidney P Elmer | 1998 | Journal of the American College of Cardiology1998，，1： | 2 |
| 2 | Quality of life, work productivity impairment and healthcare resources in inflammatory bowel diseases in Brazil显示文摘BACKGROUND Inflammatory bowel diseases(IBD)have been associated with a low quality of life(QoL)and a negative impact on work productivity compared to the general population.Information about disease control,patient-reported outcomes(PROs),treatment patterns and use of healthcare resources is relevant to optimizing IBD management.AIM To describe QoL and work productivity and activity impairment(WPAI),treatment patterns and use of healthcare resources among IBD patients in Brazil.METHODS A multicenter cross-sectional study included adult outpatients who were previously diagnosed with moderate to severe Crohn’s disease(CD)or ulcerative colitis(UC).At enrolment,active CD and UC were defined as having a Harvey Bradshaw Index≥8 or a CD Activity Index≥220 or calprotectin>200μg/g or previous colonoscopy results suggestive of inadequate control(per investigator criteria)and a 9-point partial Mayo score≥5,respectively.The PRO assessment included the QoL questionnaires SF-36 and EQ-5D-5L,the Inflammatory Bowel Disease Questionnaire(IBDQ),and the WPAI questionnaire.Information about healthcare resources and treatment during the previous 3 years was collected from medical records.Chi-square,Fisher’s exact and Student’s t-/Mann-Whitney U tests were used to compare PROs,treatment patterns and the use of healthcare resources by disease activity(α=0.05).RESULTS Of the 407 patients in this study(CD/UC:64.9%/35.1%,mean age 42.9/45.9 years,54.2%/56.6%female,38.3%/37.1%employed),44.7%/25.2%presented moderate-to-severe CD/UC activity,respectively,at baseline.Expressed in median values for CD/UC,respectively,the SF-36 physical component was 46.6/44.7 and the mental component was 45.2/44.2,the EQ-visual analog scale score was 80.0/70.0,and the IBDQ overall score was 164.0/165.0.Moderate to severe activity,female gender,being unemployed,a lower educational level and lower income were associated with lower QoL(P<0.05).Median work productivity impairment was 20%and 5%for CD and UC patients,respectively,and activity impairment was 30%,the latter being higher among patients with moderate to severe disease activity compared to patients with mild or no disease activity(75.0%vs 10.0%,P<0.001).For CD/UC patients,respectively,25.4%/2.8%had at least one surgery,38.3%/19.6%were hospitalized,and 70.7%/77.6%changed IBD treatment at least once during the last 3 years.The most common treatments at baseline were biologics(75.3%)and immunosuppressants(70.9%)for CD patients and 5-ASA compounds(77.5%)for UC patients.CONCLUSION Moderate to severe IBD activity,especially among CD patients,is associated with a substantial impact on QoL,work productivity impairment and an increased number of IBD surgeries and hospitalizations in Brazil. | Rogerio Serafim Parra Julio MF Chebli Heda MBS Amarante Cristina Flores Jose ML Parente Odery Ramos Milene Fernandes Jose JR Rocha Marley R Feitosa Omar Feres Antonio S Scotton Rodrigo B Nones Murilo M Lima Cyrla Zaltman Carolina D Goncalves Isabella M Guimaraes Genoile O Santana Ligia Y Sassaki Rogerio S Hossne Mauro Bafutto Roberto LK Junior Mikaell AG Faria Sender J Miszputen Tarcia NF Gomes Wilson R Catapani Anderson A Faria Stella CS Souza Rosana F Caratin Juliana T Senra Maria LA Ferrari | 2019 | World Journal of Gastroenterology2019，25，38： | 2 |
| 3 | Unfrozen water contents of submarine permafrost determined by nuclear magnetic resonance 显示文摘 | Tice A R Anderson D M Sterrett K F | 1981 | Engineering Geology1981，18，： | 2 |
| 4 | The characterization and comparative analysis of high-molecular-weight glutenin genes from genomes A and B of a hexaploid bread wheat显示文摘 | Anderson O D Greene F C | 1989 | Theor Appl Genet1989，77，： | 1 |
| 5 | Can stem cells cross lineage boundaries?显示文摘 | Anderson D J Gage F H Weissman I L | 2001 | Nat Med2001，7，： | 1 |
| 6 | Ultrastructural morphmetric analysis of BrucelIa abortus-infected trophoblasts in experimental placentitis显示文摘 | Anderson T D Cheville N F | 2006 | Pathol2006，124，： | 1 |
| 7 | A review of headed-stud design criteria in the six edition of the PCI design handbook 显示文摘 | Anderson N S Meinheit D F | 2007 | PCI Journal2007，52，1： | 1 |
| 8 | Optimal supply function in electricity markets with option contracts and nonsmooth costs 显示文摘 | Anderson E D Xu H F | 2006 | Mathematical Methods of Operations Research2006，63，3： | 1 |
| 9 | A prospective,randomized trial of intravenous fat emulsion administration in trauma victims requiring total parenteral nutrition显示文摘 | Battistella F D Widergren J T Anderson J T | 1997 | J Trauma1997，43，1： | 1 |
| 10 | A DNA-based approach to the identification of insect species used for postmortem interval estimation 显示文摘 | Sperling F A Anderson G S Hickey D A | 1994 | J Forensic Sei1994，39，2： | 1 |
| 11 | Effect of Some Phthalate Esters in Human Cells in the Comet Assay显示文摘 | Anderson D Yu TW Hincal F | 1999 | Teratog Carcinog Mutagen1999，19，： | 1 |
| 12 | Risk factors for computed tomography angiography spot sign in deep and lobar intracerebral hemorrhage are shared 显示文摘 | Radmanesh F Falcone G J Anderson C D | 2014 | Stroke2014，45，6： | 1 |
| 13 | The Zero-Divisor Graph of a Commutative Ring显示文摘 | ANDERSON D F LIVINGSTON P S | 1999 | Journal Algebra1999，217，： | 1 |
| 14 | The zero-divisor graph of a commutative ring显示文摘 | ANDERSON D F LIVINGSTON P S | 1999 | J Algebra1999，，217： | 1 |
| 15 | The severe and moderate phenotypes of heritable Mac-1,LAK-1deficiency; The quantitative definition and relation to leukocyte dysfunction and clinical feature显示文摘 | Anderson D C Schmalsteig F C Finegold M J | 1985 | J Infect Dis1985，152，4： | 1 |
| 16 | The ethylene biosynthesis inducing xylanase: its induction in Trichoderma viride and certain plant pathogens显示文摘 | DEAN J F D GAMBLE H R ANDERSON J D | 1989 | Phytopathology1989，，79： | 1 |
| 17 | Optimal supply function in electricity markets with option contracts and non-smooth costs显示文摘 | Anderson E D Xu H F | 2006 | Mathematical Methods of Operations Research2006，63，3： | 1 |
| 18 | The characterization and compara tive analysis of high-molecular weight glutenin genes from ge nomes A and B of a hexaploid bread wheat 显示文摘 | Anderson O D Greene F C | 1989 | Theoretical and Applied Genetics1989，77，： | 1 |
| 19 | The characterization and comparative analysis of high-molecular-weight glutenin genes from genomes A and B of a hexaploid bread-wheat 显示文摘 | ANDERSON D D Greene F C | 1989 | Theoretical and Applied Genetics1989，77，： | 1 |
| 20 | Identification and prediction of unsteady transonic aerodynamic loads by multi-layer functions显示文摘 | Marques F D Anderson J | 2001 | Journal of Fluids and Structures2001，15，1： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员