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| 1 | 预期寿命估计对脊柱转移瘤手术选择与预后预测的临床意义显示文摘背景与目的:目前,临床上对脊柱转移瘤患者是否采取手术治疗以及如何选择手术仍然存在较大的争议。预期寿命的估计是手术选择的决定因素之一。本研究旨在评价Tokuhashi和Tomita评分系统这两种常用的预期寿命估计方法对硬膜外脊柱转移瘤患者手术选择与预后预测的临床价值。方法:对2001年1月至2004年4月丹麦奥胡斯大学医院脊柱外科中心收治的169例硬膜外脊柱转移瘤入组患者,术前用Tokuhashi与Tomita评分系统进行评分以及估计预期寿命,并结合Tomita脊柱肿瘤分型,选择实施手术分级治疗。术后6个月、12个月以及24个月分别进行前瞻性随访观察。对在预期寿命为“3个月内死亡”、“6个月内死亡”以及“12个月内死亡”的患者通过Tokuhashi与Tomita评分系统绘制受试者作业特征曲线(receiveroperatingcharacteristiccurves,ROC曲线),比较两个评分系统对预期寿命估计的准确性。同时采用Kaplan-Meier生存曲线分析法,计算Tokuhashi和Tomita评分系统各分数段患者术后的实际平均生存时间。结果:预期寿命分别为“3个月内死亡”、“6个月内死亡”以及“12个月内死亡”的病例ROC曲线分析显示,Tomita评分系统与Tokuhashi评分系统之间的差异均无显著性(各组P值分别为0.16、0.47与0.38)。Kaplan-Meier生存曲线分析显示,Tomita评分系统在4~7分之间对预后估计过高,Tokuhashi评分系统在0~8分之间对预后估计过低。结论:Tokuhashi和Tomita评分系统均可成功地预测脊柱转移瘤患者术后预后的情况。Tokuhashi评分系统可较为准确地预测生存期较短的患者,从而避免对这类患者做不必要的大手术。 | 邹学农 Anders Grejs 李海声 Kristian Hφy Ebbe S Hansen Cody Bünger | 2006 | 癌症2006，25，11： | 18 |
| 2 | Photochemical internalization (PCI) of immunotoxins targeting CD133 is specific and highly potent at femtomolar levels in cells with cancer stem cell properties显示文摘 | Monica Bostad Kristian Berg Anders H?gset Ellen Skarpen Harald Stenmark P?l K. Selbo | 2013 | Journal of Controlled Release2013，，3： | 4 |
| 3 | Comparative study of low-field NMR relaxation measurements and two traditional methods in the determination of water holding capacity of pork显示文摘 | Hanne C Bertram Henrik J Andersen Anders H Karlsson | 2000 | Meat Science2000，，2： | 2 |
| 4 | Efficacy and Safety Comparison of Liraglutide, Glimepiride, and Placebo, All in Combination With Metformin, in Type 2 Diabetes: The LEAD (Liraglutide Effect and Action in Diabetes)-2 study显示文摘 | Nauck Michael Frid Anders Hermansen Kjeld Shah Nalini S Tankova Tsvetalina Mitha Ismail H Zdravkovic Milan Düring Maria Matthews David R | 2009 | Diabetes Care2009，，： | 2 |
| 5 | Continuous distribution analysis of T2 relaxation in meat-an approach in the determination of water-holding capacity显示文摘 | Hanne C B Sune D Anders H K | 2002 | Meat Science2002，60，： | 1 |
| 6 | Ensheathing cells and methyl-prednisolone promote axonal regeneration and functional recovery in the lesioned adult rat spinal cord 显示文摘 | Nash H H Borke R C Anders J J | 2002 | J Neurosci2002，22，16： | 1 |
| 7 | Molecular anal ysis of commensal host microbial relationships in the intestine显示文摘 | Hooper L V Melissa H W Anders T | 2001 | Science2001，291，5505： | 1 |
| 8 | Displacement-length scaling and fault linkage 显示文摘 | Dawers N H Anders M H | 1995 | Journal of Structural Geology1995，17，5： | 1 |
| 9 | DICTRA, a tool for simulation of diffusional transformations in alloys显示文摘 | Annika Borgenstam Lars H?glund John ?gren Anders Engstr?m | 2000 | Journal of Phase Equilibria2000，，3： | 1 |
| 10 | Impaired glucose tolerance associated with adverse pregnancy outcomes: A population-based study in southern Sweden显示文摘 | Aberg A Rydhstroem H Frid Anders | 2001 | Am J Obstet& Gynecol2001，184，： | 1 |
| 11 | Activation of toll- like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice显示文摘 | Anders H J Vielhaauer V Eis V | 2004 | FASEB J2004，18，3： | 1 |
| 12 | Chemokines and chemokine receptors are involved in the resolution or progression of renal disease 显示文摘 | ANDERS H J VIEHHAUER V SCHLONDORFF D | 2003 | Kidney lnt2003，63，2： | 1 |
| 13 | Chemokines and chemo- kine Receptors as Therapeutic Targets in Lupus Nephritis 显示文摘 | Vielhauer V Anders H J Schlondorff D | 2007 | Seminars in Nephrology2007，27，1： | 1 |
| 14 | Failure modes in field-test- ed brass die casting dies显示文摘 | ANDERS P STURE H JENS I3 | 2004 | Journal of terials Processing Technology2004，148，1： | 1 |
| 15 | Structures and color properties of new red wine pigments 显示文摘 | Anders E H Kevin P Yoji H | 2003 | Tetrahedron Letters2003，44，： | 1 |
| 16 | Dynamic coupling of computational fluid dynamics and thermodynamics software: applied on a top blown converter显示文摘 | Mikael ERSSON Lars H?GLUND Anders TILLIANDER | 2008 | ISIJ International2008，48，2： | 1 |
| 17 | Overlapping faults, intrabasin highs, and growth normal faults显示文摘 | Anders M H Schlische R W | 1994 | Journal of Geology1994，102，： | 1 |
| 18 | 2001 Volvo Award Winner in Clinical Studies: Lumbar Fusion Versus Nonsurgical Treatment for Chronic Low Back Pain: A Multicenter Randomized Controlled Trial From the Swedish Lumbar Spine Study Group显示文摘 | Peter Fritzell Olle H?gg Per Wessberg Anders Nordwall | 2001 | Spine2001，，23： | 1 |
| 19 | Organic compounds in meteorites显示文摘 | ANDERS E HAYATSU R STUDIER H | 1973 | Science1973，182，： | 1 |
| 20 | New Method of Purification for Establishing Primary Cultures of Ensheathing Cells from the Adult Olfactory Bulb显示文摘 | Nash H H Borke R C Anders J J | 2001 | Glia2001，34，1： | 1 |
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