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| 1 | Proton nuclear magnetic resonance-based metabonomic models for non-invasive diagnosis of liver fibrosis in chronic hepatitis C:Optimizing the classification of intermediate fibrosis显示文摘AIM To develop metabonomic models(MMs), using 1 H nuclear magnetic resonance(NMR) spectra of serum, to predict significant liver fibrosis(SF: Metavir ≥ F2), advanced liver fibrosis(AF: METAVIR ≥ F3) and cirrhosis(C: METAVIR = F4 or clinical cirrhosis) in chronic hepatitis C(CHC) patients. Additionally, to compare the accuracy of the MMs with the aspartate aminotransferase to platelet ratio index(APRI) and fibrosis index based on four factors(FIB-4). METHODS Sixty-nine patients who had undergone biopsy in the previous 12 mo or had clinical cirrhosis were included. The presence of any other liver disease was a criterion for exclusion. The MMs, constructed using partial least squares discriminant analysis and linear discriminant analysis formalisms, were tested by cross-validation, considering SF, AF and C. RESULTS Results showed that forty-two patients(61%) presented SF, 28(40%) AF and 18(26%) C. The MMs showed sensitivity and specificity of 97.6% and 92.6% to predict SF; 96.4% and 95.1% to predict AF; and 100% and 98.0% to predict C. Besides that, the MMs correctly classified all 27(39.7%) and 25(38.8%) patients with intermediate values of APRI and FIB-4, respectively. CONCLUSION The metabonomic strategy performed excellently in predicting significant and advanced liver fibrosis in CHC patients, including those in the gray zone of APRI and FIB-4, which may contribute to reducing the need for these patients to undergo liver biopsy. | Andrea Dória Batista Carlos Jonnatan Pimentel Barros Tássia Brena Barroso Carneiro Costa Michele Maria Goncalves de Godoy Ronaldo Dionísio Silva Joelma Carvalho Santos Mariana Montenegro de Melo Lira Norma ThoméJucá Edmundo Pessoa de Almeida Lopes Ricardo Oliveira Silva | 2018 | World Journal of Hepatology2018，10，1： | 2 |
| 2 | 年龄对高血压患者血压评估的影响显示文摘 | 张玲玉 叶鹏 Lima NK Duarte PO da Freiria MG Almeida EF Rezende T Machado JV | 2010 | 中华高血压杂志2010，18，11： | 2 |
| 3 | 原因不明的脑卒中患者心房纤维化增加:心脏磁共振成像研究显示文摘一些被归类为原因不明的缺血性脑卒中患者可能有左心房和左心耳结构或功能的改变,增加了他们的血栓栓塞风险。该研究使用心脏磁共振成像比较不同病因的缺血性脑卒中患者的左心房和左心耳结构及功能。研究人员前瞻性连续纳入缺血性脑卒中患者样本。 | 刘莉 叶鹏 Fonseca AC Alves P Inácio N Marto JP Viana-Baptista M Pinho-E-Melo T Ferro JM Almeida AG | 2018 | 中华高血压杂志2018，26，3： | 2 |
| 4 | Sensor-based demand-cont -rolled ventilation: a review 显示文摘 | William J Fisk Anibal T De Almeida | 1998 | Energy and Buildings1998，29，： | 1 |
| 5 | Ultrasound-assisted single-drop microextraction for the determination of cadmium in vegetable oils using high-resolution continuum source electrothermal atomic absorption spectrometry显示文摘 | ALMEIDA J S ANUNCIACAO T A BRANDAO G C | 2015 | Spectrochimica Acta Part B: Atomic Spectroscopy2015，107，： | 1 |
| 6 | One-week dual therapy with ranitidine bismuth citrate and clarithromycin for the treatment of Helicobacter pylori infection in Brazilian patients with peptic ulcer显示文摘AIM: To assess the efficacy and safety of ranitidine bismuth citrate plus clarithromycin given for 1 wk in Brazilian patients with peptic ulcer.METHODS: One hundred and twenty patients with peptic ulcer were randomized in two treatment groups: (1) 1-wk regimen consisting of ranitidine bismuth citrate 400 mg b.i.d. with clarithromycin 500 mg b.i.d. or (2) 2-wk regimen of the same treatment. Eradication of the infection was considered when both the histologic examination and the urease test were negative for the infection 3 mo after treatment.RESULTS: By intention to treat analysis, Helicobacter pylori (H pylori) was eradicated in 73% and 76% of patients, respectively treated for 1 or 2 wk (P>0.05). By per protocol analysis, the eradication rates were 80% and 83%,respectively, in patients treated for 1 or 2 wk (P>0.05). Nine patients (8.2%) reported minor side effects. CONCLUSION: One-week therapy with ranitidine bismuth citrate and clarithromycin is safe, well tolerated and effective for treatment of H pylori infection, andappears to be comparable to the 2-wk regimen in terms of efficacy. | Maria Aparecida Mesquita S(o|^)nia Letícia Silva Lorena Jazon Romilson Souza Almeida Ciro Garcia Montes Fábio Guerrazzi Luciana T Campos José Murilo Rubiota Zeitune | 2005 | World Journal of Gastroenterology2005，11，23： | 1 |
| 7 | Immune function in young children with previous pulmonary or miliary/meningeal tuberculosis and impact of BCG vaccination 显示文摘 | Terling TR Martire T de Almeida AS | 2007 | Pediatrics2007，120，4： | 1 |
| 8 | Lactate dehydrogenase activity as an effect criterion in toxicity tests with Daphnia magna straus 显示文摘 | Diamantino T Almeida E Soares A | 2001 | Chemosphere2001，45，45： | 1 |
| 9 | On quasi-orthodox semigroups with inverse transversals显示文摘 | BLYTH T S ALMEIDA SANTOS M H | 1997 | Proc Edinburgh Math Soc1997，40，3： | 1 |
| 10 | Particle swarm-based olfactory guided search 显示文摘 | L Marques U Nunes A T de Almeida | 2006 | Autonomous Robotics (S0929-5593)2006，20，： | 1 |
| 11 | CD28 costimulation improves expansion and persistence of chimeric antigen receptor-modified T cells in lymphoma patients显示文摘 | Savoldo Barbara Ramos Carlos Almeida Liu Enli Mims Martha P Keating Michael J Carrum George Kamble Rammurti T Bollard Catherine M Gee Adrian P Mei Zhuyong Liu Hao Grilley Bambi Rooney Cliona M Heslop Helen E Brenner Malcolm K Dotti Gianpie | 2011 | Journal of Clinical Investigation2011，，5： | 1 |
| 12 | Raman amplifier performance of dispersion compensating fibers 显示文摘 | CANI S P N FREITAS M ALMEIDA R T R | 2003 | Microwave and Optoelectronics Conference2003，，2： | 1 |
| 13 | A new method for rapidly generating gene-targeting vectors by engi- neering BACs through homologous recombination in bacteria显示文摘 | Cotta de Almeida V Schonhoff S Shibata T | 2003 | Genome Res2003，13，9： | 1 |
| 14 | Indexing the trajectories of moving objects in networks显示文摘 | de Almeida V T Guting R H | 2005 | Geolnformatica2005，9，1： | 1 |
| 15 | Learning Sensor-Based Navigation of a Real Mobile Robot in Unknown Worlds 显示文摘 | Rui Araujo Anibal T de Almeida | 1999 | IEEE Transactions on System Man and Cybernetics-Part B: Cybernetics1999，29，2： | 1 |
| 16 | Modeling and Querying Moving Objects in Networks显示文摘 | Guting R H de Almeida V T | 2006 | The Interna tional Journal on Very Large DataBases2006，15，2： | 1 |
| 17 | Oxidising alternative species to chromium Ⅵ in zinc galvanised steel 显示文摘 | Almeida E Diamantino T C Figueiredo M O | 1998 | Surface and Coatings Technology1998，106，1： | 1 |
| 18 | ICP-MS determination of strontium isotope ratio in wine in order to be used as a fingerprint of its regional origin显示文摘 | Almeida C M Vasconcelos M T S D | 2001 | Journal of Analytical Atomic Spectrometry2001，16，6： | 1 |
| 19 | On weakly multiplicative inverse transversals显示文摘 | BLYTH T S ALMEIDA SANTOS M H | 1993 | Proc Edinburgh Math Soc1993，37，1： | 1 |
| 20 | Optimized expression of a thermostable xylanase from Thermomyces lanuginosus in Pichia pastoris显示文摘 | Damaso M C T Almeida M S Kurtenbach E | 2003 | Appl Environ Microbiol2003，69，： | 1 |
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