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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | Spatial and temporal variation of nitrous oxide and methane flux between subtropical mangrove sediments and the atmosphere显示文摘 | ALLEN D E DALAL R C RENNENBERG H | 2007 | Soil Biology and Biochemistry2007，39，2： | 1 |
| 3 | Red imported fire ant impacts on northern bobwhite populations显示文摘 | Allen C R Lutz R S Demarais S | 1995 | Ecol Appl1995，，3： | 1 |
| 4 | The impact of FLT3 intenaal tandem duplication mutant level, number, size,and interaction with NPM1 mutations in a large co- hort of young adult patients with acute myeloid leukemia 显示文摘 | GALE R E GREEN C ALLEN C | 2008 | Blood2008，111，： | 1 |
| 5 | Strategies for the development of nanocrystalline materials through devitrification显示文摘 | FOLEY J C ALLEN D R PEREPEZKO J H | 1997 | Mater Sci Eng1997，，： | 1 |
| 6 | Red River and associated faults,Yunnan Province,China:Quaternary geology,slip rates and seismic hazard显示文摘 | ALLEN C R GILLESPIE A R HAN Y | 1984 | Geological Society of America Bulletin1984，95，： | 1 |
| 7 | Voltammetric studies of the interaction of metal chelates with DNA 2 tris-chelated complexes of cobalt(Ⅲ) and iron(Ⅱ) with 1,10-phenanthroline and 2,2'-bipyridine显示文摘 | Michael T C Marisol R Allen J B | 1989 | J Am Chem Soc1989，111，24： | 1 |
| 8 | Recent advances in biology and immunobiology of Eimeria species and in diagnosis and control of infection with these coccidian parasites of poultry 显示文摘 | Allen P C Fetterer R H | 2002 | Clin Microbiol Rev2002，15，1： | 1 |
| 9 | Adaptation of HIV-1to human leukocyte antigen class I显示文摘 | Kawashima Y Pfafferott K Frater J Matthews P Payne R Addo M Gatanaga H Fujiwara M Hachiya A Koizumi H Kuse N Oka S Duda A Prendergast A Crawford H Leslie A Brumme Z Brumme C Allen T Brander C Kaslow R Tang J Hunter E Allen S Mulenga J Branch S Roach T John M Mallal S Ogwu A Shapiro R Prado J G Fidler S Weber J Pybus O G Klenerman P Ndung'u T Phillips R Heckerman D Harrigan P R Walker B D Takiguchi M Goulder P | 2009 | Nature2009，458，7238： | 1 |
| 10 | Radial growth impact of pine false webworm defoliation on eastern white pine 显示文摘 | Mayfield Ⅲ A E Allen D C Briggs R D | 2005 | Canadian Journal of Forest research2005，35，5： | 1 |
| 11 | Neuroglobin in the rat brain: localization 显示文摘 | Hundahl C A Allen G C Nyengaard J R | 2008 | Neuroendocrinology2008，88，3： | 1 |
| 12 | Expression of growth hormonereleasing factor,growth hormone,insulin-like growth factor1 and its binding proteins in human lung显示文摘 | Allen J T Bloor C A Kedia R A | 2000 | Neuropeptides2000，34，2： | 1 |
| 13 | Bringing Engineer- ing Research to Market: How Universities, Industry and Government Are Attempting to Solve the Problem显示文摘 | Allen Kathleen R Taylor Cyrus C | 2005 | Engineering Management Journal2005，17，3： | 1 |
| 14 | Mea- surements of acid volatile sulfide and simultaneously ex- tracted metals are irreproducible among laboratories显示文摘 | HAMMERSCHMIDT C R ALLEN BURTON J G | 2010 | En- vironmental Toxicology and Chemistry2010，29，7： | 1 |
| 15 | Dynamic contrast enhanced MRI in prostate cancer显示文摘 | Alonzi R Padhani A R Allen C | 2007 | Eur J Radio12007，63，3： | 1 |
| 16 | Use of an immunoassay as a means to detect polychlorinated biphenyls in animal fat显示文摘 | Jaborek H S Host C V Allen R | 2001 | Food Additives and Contaminants2001，18，2： | 1 |
| 17 | Spatial and tempo- ral variation of nitrous oxide and methane flux between subtropical man- grove sediments and the atmosphere 显示文摘 | ALLEN D E DALAL R C RENNENBERG H Z | 2007 | Soil Biology & Biochemistry2007，39，： | 1 |
| 18 | Potentially active faults in dam foundations显示文摘 | SHERARD J L CLUFF L S ALLEN C R | 1974 | Géotechnique1974，，03： | 1 |
| 19 | Olive oil volatilecompounds,flavour development and quality : A critical review显示文摘 | Kalua C M Allen M S Bedgood D R | 2007 | Food Chem2007，100，： | 1 |
| 20 | Chloroplast composition and structure differences in a soybean mutant显示文摘 | Keck R W Dilley R A Allen C F | 1970 | Plant Physiol1970，46，： | 1 |
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