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| 1 | Retrospective study on mixed neuroendocrine non-neuroendocrine neoplasms from five European centres显示文摘BACKGROUND Mixed neuroendocrine non-neuroendocrine neoplasm(MiNEN)is a rare diagnosis,mainly encountered in the gastro-entero-pancreatic tract.There is limited knowledge of its epidemiology,prognosis and biology,and the best management for affected patients is still to be defined.AIM To investigate clinical-pathological characteristics,treatment modalities and survival outcomes of a retrospective cohort of patients with a diagnosis of MiNEN.METHODS Consecutive patients with a histologically proven diagnosis of MiNEN were identified at 5 European centres.Patient data were retrospectively collected from medical records.Pathological samples were reviewed to ascertain compliance with the 2017 World Health Organisation definition of MiNEN.Tumour responses to systemic treatment were assessed according to the Response Evaluation Criteria in Solid Tumours 1.1.Kaplan-Meier analysis was applied to estimate survival outcomes.Associations between clinical-pathological characteristics and survival outcomes were explored using Log-rank test for equality of survivors functions(univariate)and Cox-regression analysis(multivariable).RESULTS Sixty-nine consecutive patients identified;Median age at diagnosis:64 years.Males:63.8%.Localised disease(curable):53.6%.Commonest sites of origin:colon-rectum(43.5%)and oesophagus/oesophagogastric junction(15.9%).The neuroendocrine component was;predominant in 58.6%,poorly differentiated in 86.3%,and large cell in 81.25%,of cases analysed.Most distant metastases analysed(73.4%)were occupied only by a poorly differentiated neuroendocrine component.Ninety-four percent of patients with localised disease underwent curative surgery;53%also received perioperative treatment,most often in line with protocols for adenocarcinomas from the same sites of origin.Chemotherapy was offered to most patients(68.1%)with advanced disease,and followed protocols for pure neuroendocrine carcinomas or adenocarcinomas in equal proportion.In localised cases,median recurrence free survival(RFS);14.0 months(95%CI:9.2-24.4),and median overall survival(OS):28.6 months(95%CI:18.3-41.1).On univariate analysis,receipt of perioperative treatment(vs surgery alone)did not improve RFS(P=0.375),or OS(P=0.240).In advanced cases,median progression free survival(PFS);5.6 months(95%CI:4.4-7.4),and median OS;9.0 months(95%CI:5.2-13.4).On univariate analysis,receipt of palliative active treatment(vs best supportive care)prolonged PFS and OS(both,P<0.001).CONCLUSION MiNEN is most commonly driven by a poorly differentiated neuroendocrine component,and has poor prognosis.Advances in its biological understanding are needed to identify effective treatments and improve patient outcomes. | Melissa Frizziero Xin Wang Bipasha Chakrabarty Alexa Childs Tu V Luong Thomas Walter Mohid S Khan Meleri Morgan Adam Christian Mona Elshafie Tahir Shah Annamaria Minicozzi Wasat Mansoor Tim Meyer Angela Lamarca Richard A Hubner Juan W Valle Mairéad G McNamara | 2019 | World Journal of Gastroenterology2019，25，39： | 13 |
| 2 | Immune checkpoint inhibitor-mediated colitis in gastrointestinal malignancies and inflammatory bowel disease显示文摘Immune checkpoint inhibitors(ICI)have markedly changed the landscape of cancer therapy.By re-invigorating the immune system against tumors,ICI provide novel therapeutic options for a broad variety of malignancies,including many gastrointestinal(GI)cancers.However,these therapies can also induce autoimmune-like side effects in healthy tissue across the body.One of the most common of these side effects is ICI-mediated colitis and diarrhea(IMC).Here,we review the incidence and risk of IMC in ICI therapy,with a focus on what is known regarding IMC in patients with GI malignancies.We also discuss data available on the use of ICI and risk of IMC in patients with pre-existing inflammatory bowel disease,as these patients may have increased risk of IMC due to their underlying intestinal pathology. | Alexa R Weingarden Samuel J S Rubin John Gubatan | 2021 | World Journal of Gastrointestinal Oncology2021，13，8： | 3 |
| 3 | Isolation and analysis of mRNA from environmental microbial communities 显示文摘 | MCGRATH K C THOMAS-HALL S R CHENG C T LEO L ALEXA A SCHMIDT S SCHENK P M | 2008 | J Microbiol Meth2008，75，17： | 1 |
| 4 | Cellular mi influence the ability of mammary epithelial to undergo cell cycle 显示文摘 | Alexa I J Apolinar M M Charles H S | 2011 | PLoSOne2011，6，18： | 1 |
| 5 | Imaging with total reflection fluorescence microscopy for the cell biologist 显示文摘 | ALEXA L M SANFORD M S JOSHUA Z R | 2010 | Journal of cell science2010，，21： | 1 |
| 6 | Progressive point set surfaces显示文摘 | Fleishman S Cohen-Or D Alexa M | 2003 | ACM Transactions on Graphics2003，22，4： | 1 |
| 7 | Association of matrix metalloproteinases with MRI indices of brain ischemia and aging 显示文摘 | Jose Rafael Romero Ramachandran S Vasan Alexa S | 2010 | Neurobiology of aging2010，31，12： | 1 |
| 8 | Detection and characterization of Clostridium perfringens in the fece of healthy and diarrheic dogs显示文摘 | Goldstein M R Kruth S A Alexa M E | 2012 | Can J Vet Res2012，76，： | 1 |
| 9 | Computing and rendering point set surfaces 显示文摘 | ALEXA M BEHR J FLEISHMAN S | 2003 | IEEE Transactions on Visaulization and Computer Graphics2003，9，1： | 1 |
| 10 | Prevalence and correlates of si-lent cerebral infarcts in the Framingham Offspring Study 显示文摘 | Rohit RD Sudha S Alexa SB | 2008 | Stroke2008，39，： | 1 |
| 11 | Measuring the impact of unfamiliar transit travel using a university access survey显示文摘 | LORELEI S GRAHAM C ALEXA D | 2013 | Transport Policy2013，30，： | 1 |
| 12 | Progressive Point Set Surfaces显示文摘 | S Fleishman D Cohen-Or M Alexa | 2003 | ACM Transactions on Graphics2003，22，4： | 1 |
| 13 | Progressive Point Set Surfaces显示文摘 | Fleishman S Cohen-Or D Alexa M | 2003 | ACM Transactions on Graphics2003，22，4： | 1 |
| 14 | Computing and rendering point set surfaces显示文摘 | Alexa M Behr J Fleishman S | 2003 | IEEE Transactions on Visualization and Computer Graphics2003，9，1： | 1 |
| 15 | Serological Survey of Dogs From Egypt for Antibodies to Leishmania Species显示文摘 | Rosypal Alexa C Bowman Shanae S Epps Samuel A El Behairy A M Hilali M Dubey J P | 2013 | The Journal of Parasitology2013，，1： | 1 |
| 16 | The influence of gender and age on disability following ischemic stroke: the Framingham study显示文摘 | Margaret Kelly-Hayes Alexa Beiser Carlos S Kase Amy Scaramucci Ralph B D’Agostino Philip A Wolf | 2003 | Journal of Stroke and Cerebrovascular Diseases2003，，3： | 1 |
| 17 | Using internet discussion boards as virtual focus groups 显示文摘 | Margaret FM Alexa SD Ora S | 2003 | Advances in Nursing Science2003，26，4： | 1 |
| 18 | Stirred bead mill grinding of gibbsite : surface and morphological changes 显示文摘 | ALEXA T C RAKESH KUMARA ROY S K | 2008 | Adv Powder Tech2008，19，5： | 1 |
| 19 | Age at Natural Menopause and Risk of Ischemic Stroke: The Framingham Heart Study显示文摘 | Lynda D Lisabeth Alexa S Beiser Devin L Brown | 2009 | Stroke2009，40，4： | 1 |
| 20 | The life risk of stroke显示文摘 | Sudha S Alexa B Margaret KH | 2006 | Stroke2006，37，： | 1 |
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