|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Gastric juice for the diagnosis of H pylori infection in patients on proton pump inhibitors显示文摘AIM: To determine the efficacy of gastric juice polymerase chain reaction (PCR) for the detection of H pylori infection in comparison with histology and gastric antral biopsy PCR in patients on a proton pump inhibitor (PPI). METHODS: Eighty-five consecutive patients with dyspeptic symptoms were enrolled. Gastric biopsies for histology, PCR and gastric juice were collected at endoscopy for PCR of the H pylori urease C gene (ure C). Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV), accuracy, positive and negative likelihood ratio for PCR of gastric juice for the H pylori ure C gene was compared to histology and gastric antral biopsy H pylori ure C PCR in patients with and without PPI. RESULTS: Gastric juice PCR was positive in 66 (78%) patients. Histology showed H pylori associated gastritis in 57 (67%). Gastric biopsy PCR was positive in 72 (85%). In patients not taking PPI, the sensitivity, specificity, PPV, NPV, accuracy and positive and negative likelihood ratio for gastric juice PCR were 89%, 72%, 91%, 67%, 90%, 85%, 3.1 and 0.1 respectively. In patients on PPI these values were 86%, 100%%, 100%, 29%, 86%, 9.5 and 1.4, respectively. CONCLUSION: Gastric juice PCR for the diagnosis of H pylori infection has increased sensitivity compared to histology with PPI. The use of gastric juice PCR is recommended to confirm H pylori status in patients taking PPIs. | Javed Yakoob Shahid Rasool Zaigham Abbas Wasim Jafri Shahab Abid Muhammad Islam Zubair Ahmad | 2008 | World Journal of Gastroenterology2008，14，10： | 4 |
| 2 | A comparative overview of general risk factors associated with the incidence of colorectal cancer显示文摘 | Sabha Rasool Showkat Ahmad Kadla Vamiq Rasool Bashir Ahmad Ganai | 2013 | Tumor Biology2013，，： | 2 |
| 3 | Evaluation of biomarkers, genetic mutations, and epigenetic modifications in early diagnosis of pancreatic cancer显示文摘BACKGROUND Pancreatic cancer(PC)is one of the deadliest malignancies with an alarming mortality rate.Despite significant advancement in diagnostics and therapeutics,early diagnosis remains elusive causing poor prognosis,marred by mutations and epigenetic modifications in key genes which contribute to disease progression.AIM To evaluate the various biological tumor markers collectively for early diagnosis which could act as prognostic biomarkers and helps in future therapeutics of PC in Kashmir valley.METHODS A total of 50 confirmed PC cases were included in the study to evaluate the levels of carbohydrate antigen 19-9(CA 19-9),tissue polypeptide specific antigen(TPS),carcinoembryonic antigen(CEA),vascular endothelial growth factor-A(VEGF-A),and epidermal growth factor receptor(EGFR).Mutational analysis was performed to evaluate the mutations in Kirsten rat sarcoma(KRAS),Breast cancer type 2(BRCA-2),and deleted in pancreatic cancer-4(DPC-4)genes.However,epigenetic modifications(methylation of CpG islands)were performed in the promoter regions of cyclin-dependent kinase inhibitor 2A(p16;CDKN2A),MutL homolog 1(hMLH1),and Ras association domain-containing protein 1(RASSF1A)genes.RESULTS We found significantly elevated levels of biological markers CA 19-9(P≤0.05),TPS(P≤0.05),CEA(P≤0.001),and VEGF(P≤0.001).Molecular genetic analysis revealed that KRAS gene mutation is predominant in codon 12(16 subjects,P≤0.05),and 13(12 subjects,P≤0.05).However,we did not find a mutation in DPC-4(1203G>T)and BRCA-2(617delT)genes.Furthermore,epigenetic modification revealed that CpG methylation in 21(P≤0.05)and 4 subjects in the promoter regions of the p16 and hMLH1 gene,respectively.CONCLUSION In conclusion,CA 19-9,TPS,CEA,and VEGF levels were significantly elevated and collectively have potential as diagnostic and prognostic markers in PC.Global data of mutation in the KRAS gene commonly in codon 12 and rare in codon 13 could augment the predisposition towards PC.Additionally,methylation of the p16 gene could also modulate transcription of genes thereby increasing the predisposition and susceptibility towards PC. | Bilal Rah Manzoor Ahmad Banday Gh Rasool Bhat Omar J Shah Humira Jeelani Fizalah Kawoosa Tahira Yousuf Dil Afroze | 2021 | World Journal of Gastroenterology2021，27，36： | 2 |
| 4 | 生物入侵过程中的植物-土壤反馈:一种入侵植物的凋落物分解对其本地近缘植物的影响显示文摘植物入侵可通过正或负的植物-土壤反馈效应改变土壤的生物和非生物性质,从而影响入侵栖息地的土壤理化性质。许多入侵物种的凋落物分解可增加土壤养分,降低本地植物多样性,并导致进一步的植物入侵。关于入侵植物凋落物在不同土壤类型及深度分解及反馈效应的研究依然很少。本研究旨在明确入侵植物南美蟛蜞菊(Sphagneticola trilobata)凋落物在不同土壤类型和不同土壤深度条件下的分解情况及其对本地近缘植物蟛蜞菊(S.calendulacea)生理生长的影响。将装有南美蟛蜞菊凋落物的尼龙袋加入到不同深度(即0、2、4和6 cm)的砂土、营养土和粘土中,经6个月的分解后,回收凋落物袋并计算分解速率,随后在凋落物分解处理后的土壤中种植本地蟛蜞菊,并在生长期结束时测量其生理生态指标。研究结果表明,所有处理土壤类型中,凋落物在土壤深度为2和4 cm处分解后显著增加了土壤养分,而对本地蟛蜞菊的叶片叶绿素、叶氮含量等生长指标表现为负效应。因此,入侵植物南美蟛蜞菊凋落物分解对土壤养分表现为正的反馈效应,而对本地植物蟛蜞菊的生长表现为负效应。我们的研究结果还表明,入侵植物的凋落物分解对土壤和本地物种的影响还因凋落物分解所在的土壤深度而显著不同。未来的研究应侧重于入侵栖息地中更多本地和入侵物种的植物-土壤反馈效应,以及更多土壤类型和土壤深度的入侵植物凋落物效应。 | Jianfan Sun Susan Rutherford Muhammad Saif Ullah Ikram Ullah Qaiser Javed Ghulam Rasool Muhammad Ajmal Ahmad Azeem Muhammad Junaid Nazir Daolin Du | 2022 | Journal of Plant Ecology2022，15，3： | 2 |
| 5 | Recent Insights into Signaling Responses to Cope Drought Stress in Rice显示文摘Drought is one of the hot topics needing urgent attention in the current era of climate change.It massively disturbs the rice growth and productivity and is becoming a serious threat.The drought avoidance strategies in rice include stomatal closure,cellular adaptation and changes in root development.Moreover,the endogenous plant hormones(abscisic acid and jasmonic acid)and reactive oxygen species have paramount importance in drought tolerance in rice.The drought tolerance induces modification in biochemical,molecular and physiological properties of plants.At the molecular level,expression of several transcription-factors is modulated which further determine the activation of drought responsive gene families.Mitogen activated protein kinases and Ca signaling pathways initiate an array of signaling cascade for mediating the gene expression in rice.Approaches,conventional breeding methods combined with modern emerging techniques such as genetic engineering,to improve rice drought tolerance were discussed.This review provided recent insights into major regulatory factors against drought stress,signaling mechanisms and molecular engineering strategies(including conventional transgenic and recent genome editing approaches)to induce drought tolerance in rice. | Muhammad Mahran ASLAM Muhammad Abdul Rehman RASHID Mohammad Aquil SIDDIQUI Muhammad Tahir KHAN Fozia FARHAT Shafquat YASMEEN Imtiaz Ahmad KHAN Shameem RAJA Fatima RASOOL Mahboob Ali SIAL ZHAO Yan | 2022 | Rice science2022，29，2： | 2 |
| 6 | Efficacy of a traditional Persian medicine preparation for radiation-induced xerostomia:a randomized,open-label,active-controlled trial显示文摘BACKGROUND: Xerostomia is one of the most common side effects of radiation therapy among patients with head and neck cancers(HNC). However, conventional medicine lacks an effective treatment for radiation-induced xerostomia.OBJECTIVE: Synthesizing the traditional use of Alcea digitata and Malva sylvestris with their known beneficial effects from recent studies, we evaluated the efficacy of the herbs in the quality of life(QOL) of HNC patients with radiation-induced xerostomia.DESIGN, SETTING, PARTICIPANTS AND INTERVENTIONS: This study is a randomized, double-arm, open-label active-controlled clinical trial. We evaluated the effect of A. digitata and M. sylvestris on QOL of HNC patients with radiation-induced xerostomia compared with Hypozalix(artificial saliva). Patients were enrolled from the Imam Hossein Hospital's oncology clinic in Shahid Beheshti University of Medical Sciences, Tehran, Iran.MAIN OUTCOME MEASURES: Primary outcome measures in this trial were changes in patients' QOL assessed by the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire, Head and Neck Module(EORTC QLQ-H&N 35).RESULTS: Between-group analysis showed that the intervention group patients obtained significantly lower(better) total EORTC QLQ-H&N 35 scores as compared to the control group at the end of the intervention period(P = 0.007). Mean scores of dry mouth of EORTC QLQ-H&N 35 was also significantly lower(better) in the intervention group as compared to the control group(P = 0.017).CONCLUSION: Traditional Persian medicine preparation of hollyhocks and common mallow should be considered as a suitable treatment for xerostomia and improving QOL in HNC patients with radiation-induced xerostomia.TRIAL REGISTRATION: The trial was registered in Clinical Trials.gov with Identifier: NCT02854358. | Ghazaleh Heydarirad Hossein Rezaeizadeh Rasool Choopani Seyed Hamdollah Mosavat Ahmad Ameri | 2017 | Journal of Integrative Medicine2017，15，3： | 2 |
| 7 | Eudragit FS based colonic microparticls of metoprolol tartrate显示文摘 | Rasool F Ahmad M Murtaza G | | 0，，2： | 1 |
| 8 | Estimation of generalized logistic distribution by probability weighted moments 显示文摘 | Rasool M T Arshad M Ahmad M I | 2002 | Pakistan Journal of Applied Science2002，2，4： | 1 |
| 9 | Neonatal adrenal hemorrhage presenting as late onset neonatal jaundice 显示文摘 | QURESHI U A AHMAD N RASOOL A | 2009 | J Indian ASsoc Pediatr Surg2009，14，4： | 1 |
| 10 | Neo- natal adrenal hemorrhage presenting as late onset neonatal jaundice显示文摘 | Umar Amin Qureshi Nisar Ahmad Akhter Rasool | 2009 | Journal of Indian Association of Pediatric Sur- geons2009，14，： | 1 |
| 11 | Neonatal adrenal hemorrhage presenting as late onset neonatal jaundice显示文摘 | Qureshi UA Ahmad N Rasool A | 2009 | J Indian Assoc Pediatr Surg2009，14，4： | 1 |
| 12 | Water promoted, microwave-assisted oxidative novel deamination of N-aminoquinazolinones显示文摘A novel deamination of 2-alkyl/aryl 3-amino-4(3H)-quinazolinones series using aqueous KMnO4 under thermal condition and microwave irradiation is described. Compared to thermal condition, significantly higher yields in much shorter times were observed for reactions under microwave irradiation. A plausible mechanism has been proposed for the oxidative water-promoted deamination. | M. Arfan Rasool Khan Shazia Anjum Shabir Ahmad M. Iqbal Choudhary | 2008 | Chinese Chemical Letters2008，19，2： | 1 |
| 13 | Sheehan’s syndrome with pancytopenia—complete recovery after hormone replacement (case series with review)显示文摘 | Bashir Ahmad Laway Javid Rasool Bhat Shahnaz Ahmad Mir Raja Sultan Zaman Khan Mohd Iqbal Lone Abdul Hamid Zargar | 2010 | Annals of Hematology2010，，3： | 1 |
| 14 | Selective C-arylation of 2,5-dibromo-3-hexylthiophene via Suzuki cross coupling reaction and their pharmacological aspects显示文摘 | Ikram H M Rasool N Ahmad G | 2015 | Molecules2015，20，3： | 1 |
| 15 | Neonatal adrenal hemorrhage presenting as late onset neonatal jaundice显示文摘 | Qureshi UA Ahmad N Rasool A | | 0，，4： | 1 |
| 16 | A benzoquinone and a coumestan from Psoralea plicata显示文摘 | Khan AQ Ahmad VU | 1991 | Phytochemistry1991，30，8： | 1 |
| 17 | Effect of microbial phytase from a fungus Asporgillus niger on bioavailability of phosphorus and calcium in broiler chickens显示文摘 | AHMAD T RASOOL S SARWAR M | 2000 | Anim Feed Sci Tec2000，83，： | 1 |
| 18 | A benzoquinoneand a coumestan from Psoralea plicata显示文摘 | Rasool N Khan A Q Ahmad V U | 1991 | Phytochemistry1991，30，8： | 1 |
| 19 | Humidity Effect on Transport Properties of Titanium Dioxide Nanoparticles显示文摘金红石 TiO 2 nanoparticles 与 ∼30nm TiO 2 nanoparticle 的一条平均直径用一起沉淀方法被综合设备然后在玻璃上被制作底层。铝电极用影印石版术和真空蒸发被定义。TiO 2 nanoparticles 的暂停用超声的焦虑在 isopropanol 被准备。nanoparticles 在电极之间被扔。设备被交流电的大小在 40%–90% 亲戚湿度(RH ) 测试。TiO 2 nanoparticles 的阻抗在 100Hz 从 40% ~ 90% 随 RH 的增加到大约 80 次减少。反应时间和恢复时间是 4s 和 5s,分别地在 40% 和 90% RH 之间。在 100Hz,在 40%–90% RH 的范围的铝电极 TiO 2 nanoparticle 设备的敏感是 17M/%RH。当 RH 增加,复杂模量分析也在 TiO 2 nanoparticles 的 DC 电导率证实增加。 | Muhammad Usman Kamran Rasool S. S. Batool Z. Imran Mushtaq Ahmad Hira Jamil M. A. Rafiq M. M. Hasan | 2014 | Journal of Materials Science & Technology2014，30，8： | 0 |
| 20 | In vitro-in vivo correlation study on nimesulide loaded hydroxypropylmethylcellulose microparticles显示文摘This study involves mathematical simulation model such as in vitro-in vivo correlation(IVIVC) development for various extended release formulations of nimesulide loaded hydroxypropylmethylcellulose(HPMC) microparticles(M1,M2 and M3 containing 1,2,and 3 g HPMC,respectively and 1 g drug in each) having variable release characteristics.In vitro dissolution data of these formulations were correlated to their relevant in vivo absorption profiles followed by predictability worth analysis of these Level A IVIVC.Nimaran was used as control formulation to validate developed formulations and their respective models.The regression coefficients of IVIVC plots for M1,M2,M3 and Nimaran were 0.834 9,0.831 2,0.927 2 and 0.898 1,respectively.The internal prediction error for all formulations was within limits,i.e.,<10%.A good IVIVC was found for controlled release nimesulide loaded HPMC floating M3 microparticles.In other words,this mathematical simulation model is best fit for biowaiver studies which involves study parameters as those adopted for M3 because the value of its IVIVC regression coefficient is the closest to 1 as compared to M1 and M2. | Shujaat Ali KHAN Mahmood AHMAD Ghulam MURTAZA Muhammad Naeem AAMIR Rozina KOUSAR Fatima RASOOL Shahiq-u-ZAMAN | 2010 | 药学学报2010，45，6： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员